1,721,052 research outputs found
No association between obsessive-compulsive disorder and the 5-HT1D beta receptor gene
No full textObjective: Serotonin abnormalities may be involved in the etiopathogenesis of obsessive-compulsive disorder (OCD). The silent G-to-C substitution at nucleoticle 861 of the coding region of the 5-HT1Dbeta receptor gene may be associated with liability to OCD. The aim of this study was to investigate this association in an Italian OCD study group. Method: Genotyping for 5-HT1Dbeta was performed for 79 nuclear families of probands with OCD. The transmission/disequilibrium test was used to determine transmission of the alleles from parents to offspring. Results: Of the 79 families, 48 were informative for the analysis, i.e., both parents were genotyped for 5-HT1Dbeta, and at least one parent was heterozygous. No preferential transmission of either allele of the 5-HT1Dbeta gene was observed. Conclusions: These data do not support a role for the 5-HT1Dbeta receptor gene in conferring susceptibility to OCD. Z8 0 ZR 0 ZS 2 ZB 2
Diseño, Innovación y Transdiciplinariedad II Relaciones del Diseño con la Naturaleza, la Biología y la Tecnología
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An association study between 5-HTTLPR polymorphism, COMT polymorphism, and Tourette's syndrome
No full textSeveral lines of evidence suggest that a genetic component underlies Tourette's syndrome (TS). We investigated both the role of the insertion/deletion polymorphism in the promoter region of the serotonin transporter gene (5-HTTLPR) and that of the Val-158-Met substitution in the catechol-O-methyl-transferase (COMT) gene in conferring susceptibility to TS. Fifty-two TS patients were recruited and compared with a control group of 63 healthy subjects. Neither a genotypic nor an allelic association was found; subdividing TS patients according to clinical variables, such as a co-diagnosis of obsessive-compulsive disorder (OCD) and a positive family history for obsessive compulsive disorder or ties, also failed to reveal a significant association. The lack of significance for 5-HTTLPR and COMT polymorphisms in conferring liability to TS does not exclude a role of different functional polymorphisms in genes coding for serotonergic or dopaminergic structures in the etiology of TS. In fact, TS is a complex disorder and these genes most likely have only a minor genetic effect in its etiology. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved. ZR 0 ZS 0 Z8 2 ZB 2
La calorimetria di processo: uno strumento per il monitoraggio e controllo di reattori industriali
No full textFitting isoperibolic calorimeter data for reactions with pseudo-first order chemical kinetics
Full text linkThe non-linear least squares fitting of the chemical heat flow and the reactor temperature are compared for reactions with
pseudo-first order chemical kinetics carried out in an isoperibolic calorimeter operating quasi-isothermally. Both methods give very
similar results for the reaction rate constant and enthalpy of reaction but fitting the reactor temperature appears to have some advantages
especially when there is an enthalpy of mixing of the reagents
Experience of visually-impaired children in the enjoyment of cartoons
No full textAccessing video media by people with visual impairments is still a challenge. Audio descriptions are used as a tool to describe images that cannot be perceived by those who cannot see and cannot be understood from dialogues. The creation of audio descriptions involves (1) modifying the videos in terms of additional audio tracks with the use of tools that require specific skills, and (2) the need to alter the original video, unless the same is directly inserted by the producers. In addition, the structure and language used for audio descriptions are often adult-oriented and less designed for children with visual impairments. In this paper, we propose a solution to provide audio descriptions without editing the original videos. A pilot test with 4 children with visual impairment allowed us to evaluate the audio descriptions prepared for a series of episodes of a cartoon popular among children, and the use of the proposed system
Applicazione della Calorimetria a Temperatura Oscillante allo studio di processi di polimerizzazione
No full textTemperature Oscillation Calorimetry (TOC) is a technique for the on line determination
of heat transfer coefficient UA, and is therefore suitable for studying processes where there
is a large increase in the viscosity and a consequent decrease in UA as the reaction
proceeds.
The free radical polymerization of methyl methacrylate in ethyl acetate has been studied
in a stirred, jacketed calorimeter with a volume of two litres. Sinusoidal temperature oscillation
of amplitude 1-2°C and period 5-6 minutes are imposed on the fluid circulating in
the jacket. The heat transfer coefficient is obtained from an analysis of the oscillating
parts of the jacket and reactor temperatures, while the chemical heat flow is obtained from
the non-oscillating parts of these temperatures.
The results obtained show the utility of TOC in studying polymerization processes. A limitation
has been encountered with concentrated solution where both the temperature
oscillation and the value of UA may become irregular. Under these conditions a correlation
between UA and the stirred torque may be used to correct the values of UA
Analisi di sicurezza di processi altamente reattivi mediante l'uso di tecniche calorimetriche integrate
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