3,056 research outputs found
Contrasting activity profile of two distributed cortical networks as a function of attentional demands
No full textThe original publication is available at http://www.jneurosci.orgThis work was supported by R01 grant MH-073610 from the National Institutes of Health to Denis Paré
Is Tolerance Political? An Interview with Denis Lacorne
No full textcontribution à un site webDenis Lacorne is the author of "The Limits of Tolerance. Enlightenment Values and Religious Fanaticism" (Columbia University Press, 2019), the English translation of "Les limites de la tolérance" (Gallimard, awarded the Prix Montyon by the Académie Française). In his book, which is intellectually very inspiring because of the many questions it addresses and raises, Denis Lacorne traces the emergence of the notion of tolerance from its early thinkers to the Age of Enlightenment and finally questions the notion and its various understandings through more recent events in France and the United States. What is tolerance? Is tolerance political? Interview by Miriam Périer, CER
Timing of impulses from the central amygdala and bed nucleus of the stria terminalis to the brainstem
No full textThe amygdala and bed nucleus of the stria terminalis (BNST) are thought to subserve distinct functions with the former mediating rapid fear responses to discrete sensory cues and the latter longer “anxiety-like” states in response to diffuse environmental contingencies. Yet, these structures are reciprocally connected and their projection sites overlap extensively. To shed light on the significance of BNST-amygdala connections, we compared the antidromic response latencies of BNST and central amygdala (CE) neurons to brainstem stimulation. Whereas the frequency distribution of latencies was unimodal in BNST neurons (~10 ms mode), that of CE neurons was bimodal (~10 and ~30 ms modes). However, after stria terminalis (ST) lesions, only short-latency antidromic responses were observed, suggesting that CE axons with long conduction times course through the ST. Compared to the direct route, the ST greatly lengthens the path of CE axons to the brainstem, an apparently disadvantageous arrangement. Since BNST and CE share major excitatory basolateral amygdala (BL) inputs, lengthening the path of CE axons might allow synchronization of BNST and CE impulses to brainstem when activated by BL. To test this, we applied electrical BL stimuli and compared orthodromic response latencies in CE and BNST neurons. The latency difference between CE and BNST neurons to BL stimuli approximated that seen between the antidromic responses of BNST cells and CE neurons with long-conduction times. These results point to a hitherto unsuspected level of temporal coordination between the inputs and outputs of CE and BNST neurons, supporting the idea of shared functions.The original publication is available at: http://jn.physiology.org/cgi/content/full/100/6/342
Rehab Depot de la Plaine Saint-Denis
No full textRedesign for workshop Atelier Revision Intermediaire at the Depot de la Plaine Saint-Denis with a rehabilitation center as new functionRMITArchitecture and The Built Environmen
Severini e Denis
No full textL'A. prende in esame i controversi rapporti tra i due artisti, nel primo decennio del secolo e, più tardi, nella produzione di carattere religioso. Severini risulta influenzato da Denis più di quanto sostenga negli scritti teorici. The Author examines the controversial relationships between the two artists, in the first decade of the century and later on, in their religious production. Severini appears influenced by Denis more than he declares in his theoretic writings
The bed nucleus of the stria terminalis mediates inter-individual variations in anxiety and fear
No full textWhile learning to fear stimuli that predict danger promotes survival, the inability to inhibit fear to inappropriate cues leads to a pernicious cycle of avoidance behaviors. Previous studies have revealed large inter-individual variations in fear responding with clinically anxious humans exhibiting a tendency to generalize learned fear to safe stimuli or situations. To shed light on the origin of these inter-individual variations, we subjected rats to a differential auditory fear conditioning paradigm where one conditioned auditory stimulus (CS+) was paired to footshocks whereas a second (CS-) was not. We compared the behavior of rats that received pre-training excitotoxic lesions of the bed nucleus of the stria terminalis (BNST) to that of sham rats. Sham rats exhibit a continuum of anxious/fearful behaviors. At one end of the continuum were rats that displayed a poor ability to discriminate between the CS+ and CS-, high contextual freezing, and an anxiety-like trait in the elevated plus maze (EPM). At the other end were rats that display less fear generalization to the CS-, lower freezing to context, and a non-anxious trait on the EPM. Although BNST-lesioned rats acquired similarly high levels of conditioned fear to the CS+, they froze less than sham rats to the CS-. In fact, BNST-lesioned rats behaved like sham rats with high discriminative abilities in that they exhibited low contextual fear and a nonanxious phenotype in the EPM. Overall, this suggests that inter-individual variations in fear generalization and anxiety phenotype are determined by BNST influences on the amygdala and/or its targets.Published in Journal of Neuroscience. Copyright Society for Neuroscience.Available from the Journal of Neuroscience: http://www.jneurosci.org
Theta synchronizes the activity of medial prefrontal neurons during learning
No full textCopyright, Learning & Memory Online by Cold Spring Harbor Laboratory Press http://www.learnmem.org/This material is based upon work supported by NIMH grant R01MH-073610.The published version of this article is online at http://www.learnmem.org/cgi/doi/10.1101/lm.93240
Amygdala intercalated neurons are required for expression of fear extinction
No full textHere we test the hypothesis that ITC neurons mediate extinction by lesioning them with a toxin that selectively targets cells expressing micro-opioid receptors (microORs).This is the author's version of an accepted paper for Nature. The published article can be found at the journal's web site: http://www.nature.com/nature
Nanoelectromechanical systems for biodetection : development of an integrated transducer and biofunctionalization strategies
No full textAvec une limite de détection ultime pouvant atteindre le yoctogramme (1 yg = 10-24 g), les nanosystèmes électromécaniques (NEMS) employés comme capteurs gravimétriques présentent un fort potentiel pour la détection ultra-sensible et sans marquage de molécules biologiques. A l’heure actuelle, plusieurs défis restent cependant à relever avant de pouvoir envisager de manière réaliste leur utilisation comme outils de biodétection. Ces travaux de thèse adressent en particulier l’intégration du moyen de transduction et le développement de stratégies de biofonctionnalisation. En vue de répondre à la première problématique, l’intégration d’une couche piézoélectrique à base de Titano-Zirconate de Plomb (PZT) selon une approche de fabrication collective de réseaux de NEMS par voie descendante a été développée et caractérisée.Deux approches de biofonctionnalisation adaptées à une organisation de NEMS en réseaux,respectivement basées sur le dépôt localisé de matériel biologique par impression moléculaire et sur la structuration par photolithographie d’une couche bioréceptrice à base de polymères à empreintes moléculaires (MIP), ont ensuite été mises en oeuvre et ont permis de démontrer une première preuve de concept. Ces différentes contributions constituent un premier pas dans le développement des NEMS pour des applications de biodétection.With an ultimate limit of detection down to the yoctogram regime (1 yg = 10-24 g),nanoelectromechanical systems (NEMS) resonators used as ultra-sensitive and label-free gravimetric sensors have a high potential for biodetection applications. To date, several challenges currently limit their wide spread use as viable biosensing tools. This PhD thesis addresses the issues related to the transducer integration and the biofunctionnalization. A Lead Zirconate Titatane (PZT)-based piezoelectric transducer has been implemented according to a top-down approach compatible with collective fabrication of NEMS arrays. Two biofunctionnalization strategies, suitable for a NEMS array organization and based on the localized deposition of biological material assisted by microcontact printing and the patterning of molecularly imprinted polymers (MIP) by photolithography, have also been investigated and first proof-of-concept biosensors were demonstrated. These various contributions have the potential to drive future advancements in the realm of NEMS as effective biosensing tools
Religion in America: a Political History
No full textA Conversation with Denis Lacorne, Author of Religion in America (...)
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