1,721,051 research outputs found
Men as well have problems with their body image and with sex! A study on men suffering from eating disorders
No full textMononuclear cells in dementia
No full textAccording to the World Health Organization statistics, dementias are the largest contributors to disease burden in advanced market economies, and the leading cause of disability and dependence among older people worldwide. So far, several techniques have been developed to identify dementias with reasonable accuracy while the patient is still alive, however, no single of them has proven to be ideal, especially if you need to have a satisfactory early diagnosis. Studies of early onset dementia are largely limited by the inaccessibility to direct examination of the living human brain: it appears therefore that for a correct biochemical and molecular characterization of dementias, potential surrogate tissues must be identified. In this context, peripheral blood mononuclear cells (PBMCs) appear particularly attractive because they can be obtained in a minimally invasive manner and can be easily analyzed. This review focuses on the most representative methodologies and strategies in detecting and quantifying fluctuation in dementia that are currently being developed. In addition it provides a comprehensive evaluation of the diagnostic sensitivity of PBMCs in patients with dementia. Finally, it discusses the data supporting the use of the determination of neutral lipids (NLs) in PBMCs by Oil Red O (ORO) staining, which is a minimally invasive, cheap, easy and fast procedure, as the promising method for early detection of dementia and to search for new effective treatments
Amministrazione Comunale di La Maddalena (SS) Sopraelevazione del mercato civico di La Maddalena
No full textQuaderni del Laboratorio di Architettura, n°2
No full textRiflessioni ed esplorazioni progettuali sul tema del margine costiero dell'area metropolitana di Cagliar
Europan_9 Erice. Italia
No full textThe project area, bounded respectively by “Porta Spada” and the Church of “San Giovanni”, takes up almost entirely the eastern margin of the town:
the “third side” of the triangle which encompasses the urban fabric of Erice “on the summit”.
This location of exceptional importance however is not matched by a built border of congruous urban architectural quality. The section running between
the Church of San Giovanni and the so-called “Spanish quarter”, in particular, seems incomplete vis-à-vis its potential role as public space and is of
poor architectural and urban style.
The municipal planning actions currently under way and specific projects already in the implementation stage clearly target resolution of these
problems: however, we think that more incisive action is called for, with the right “ambition of shaping” the town.
On the western and southern sides, between Porta Spada and Porta Trapani and between the latter and the Pepoli gardens (the Balio), relations are
much clearer.
In the first portion, the relationship between urban structure and the landscape is defined by the presence of the Elimo-Punic walls, followed for a long
stretch by a broad cobblestone graded ramp and further south by an unbroken coherent border of buildings. In the second case, via Conte Pepoli,
which ends with the stairway of the gardens bearing the same name, plays a threefold role: access to town, lookout point onto the landscape and the
matrix of the main tourist routes.
In both cases, the town’s margin coincides with a public space, and is characterised by routes linking the “apexes” of the urban structure and finally
makes it possible to establish clear perceptual relations with the landscape. Moreover, on both these sides the boundary of the old town is traced by a
retaining structure or a wall. The “boundary”, whether intended for soil retention or for defence against external enemies, is therefore the place where
the greatest meanings converge, as concerns the relationship between internal and external space, and between nature and human artefact.
The project attempts to refer to these deep matrixes of Erice’s urban structure in order to raise the study area to a “rank” comparable to the other town
boundaries and enable it to achieve its latent potential.
For these reasons, the “Porocittà” project proposes recreation of the urban margin on the eastern side through the construction of a series of buildings
whose elevation at the level of the attic does not exceed that of the highest portion of via Nunzio Nasi. This condition makes it possible to create a
series of piazzas/belvedere terraces on the roofs looking out towards Valderice and Monte Cofano, linked to street level by flights of steps, ramps and
graded ramps. This new public space will help enhance the value and quality of the routes between the Church of San Giovanni and the area around
the Church del Carmine, both longitudinally and transversally. The project volumes therefore develop between the top of the belvedere squares and
level +708.00, corresponding to the base of the buildings and the roof of the underground car park. The series of house fronts consisting of a double
facade in stone elements makes the work similar to construction work or a quarry face, intentionally playing with the ambiguity between natural and
artificial elements.
The new architectural form consolidates and strengthens the coherence of the image of the old town in the part where this image is more fragile and
uneven, renewing a traditional practice which has always considered earth retaining works crucial for the beauty of cities.
The new margin is cross-cut by alleys, some public, others serving private houses. The difference in elevation and the proportions of these alleys make
it possible to recreate, by analogy, the same conditions found within the consolidated fabric: “narrow and winding alleys”, a labyrinth where visitors love
getting lost, the “narrow and steep passages” associated with the “discovery of the unexpected”: now exploring nooks and crannies, now taking in the
surrounding landscape.
The depth of the built structure and a degree of typological analogy with the matrix of the existing built stock have suggested the creation of internal
courtyards encircled by the houses. The roof and terraces thus appear crossed by passages and perforated by courtyards, confirming also in the
contemporary addition the “porous” texture of Erice’s urban structure. The apartments, mostly on a single floor, alternate with some offices and
commercial premises at street level, as required by general urban policies . The underground car park is accessible from the municipal road of Porta
Spada-Fontanelle which should be enlarged in order to add a second lane for vehicles heading in the opposite direction and a sidewalk taking to the
Spanish Quarter Complex and highlighting some areas of special interest which should be renovated: in particular “Piscina Apollinis” and the “chapel of
Maria SS di Custonaci”, but also the observation post of the civil protection department, to be set up in an unauthorised house currently under a
demolition order
Amministrazione Comunale di Villasimius (Ca) Progetto preliminare per il nuovo istituto scolastico comprensivo.
No full textAmministrazione Comunale di Carbonera (TV). Concorso di progettazione in due fasi per la realizzazione del polo scolastico di Fontane Bianche
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