1,721,048 research outputs found
Neonatal fungal infections: new strategies in diagnosis
No full textIn Neonatal Intensive Care Unit, fungal sepsis are the third leading cause of late onset sepsis among very low birth weight neonates. Many of biomarkers known are neither sensitive nor specific enough to provide an accurate diagnosis of invasive fungal infections. Indeed even today, the “gold standard” in the diagnosis of neonatal fungal sepsis is positive blood culture. Since neonatal sepsis is a multiorgan disorder that leads to metabolic changes in the organism, new technologies such as metabolomics are becoming a promising method in early diagnosis and are capable of predicting onsets, thus allowing personalized treatment and monitoring of neonatal sepsis.
Proceedings of the 10th International Workshop on Neonatology · Cagliari (Italy) · October 22nd-25th, 2014 · The last ten years, the next ten years in Neonatology
Guest Editors: Vassilios Fanos, Michele Mussap, Gavino Faa, Apostolos Papageorgio
Metabolomics and the great obstetrical syndromes - GDM, PET, and IUGR
No full textGestational diabetes mellitus, intrauterine growth restriction, and preeclamptic toxemia are common pregnancy complications that can have detrimental effects on morbidity and mortality of the mother and fetus as well as long-term health outcomes. Although they are distinct conditions, they may occur together and are often considered together as they share a common etiology of inadequate placental perfusion. The discovery and study of preventative treatments is hampered by a lack of effective screening tools to accurately identify women at the highest risk of disease. Metabolomics, an omic science, is the global quantitative assessment of endogenous metabolites within a biological system. It has proven to be a rapid approach in the identification of biomarkers predictive of the outcome of a pathological condition and the individual's response to a pharmacological treatment. We review the current and potential applications of metabolomics in maternal fetal medicine, focusing on its use as a biomarker for great obstetrical syndromes diagnosi
Metabolomics technology and their application to the study of the viral infection
No full textObjective: In the present review article we have summarized the use of the metabolomics approach to study the metabolic modifications occurring in several bio-fluids due to viral infections. The aim is to highlight the ability of metabolomics to find early fingerprints, which are related to the infections.
Methods: The 1H-NMR, UHPLC/MS/MS2, UPLC/ESI-SYNAPT-HDMS, UPLC-Q-TOF-HDMS analyses were used for the determination of several metabolites representative of the viral infections. The data were analyzed by Principal Component Analysis (PCA), Partial Least Square Discriminant Analysis (PLS-DA) and by regression techniques.
Results: The major changes were related to nucleotide, carbohydrates, lipids and amino acid metabolisms.
Conclusions: The metabolomics approach could be considered a viable option for characterization of the viral infection and for detecting on going differences in the bio-fluids composition
Nephrogenic syndrome of inappropriate antidiuresis: a novel cause of euvolemic hypotonic hyponatremia in newborns. Diagnosis and practical management.
No full textNutrimetabolomics and Adipocitokines in the "Great Obstetrical Syndromes"
No full textIn neonatal medicine, nutritional research is focusing more and more on thrifty phenotype effects, in order to understand and prevent the development of long-term diseases. lschemic placental disease which brings together Gestational diabete, Preeclamptic Toxemia, and Intrauterine Growth Restriction, the "Great Obstetrical Syndromes" (GOS), originates from sugar.and lipid metabolism. Adipokines and metabolomics can be valuable tools for the diagnosis of obstetrical syndromes and addressing nutrition. Inappropriate nutrition, even in the first periods of life, can accelerate the development of chronic metabolic diseases, especially in the pediatric age. The purpose of this review is firstly to critically examine the information provided by the studies of metabolomics on GOS's and better understand their origin. Secondly, it reflects on the IUGR metabolism and on applications of metabolomics in nutrition and its "nutrimetabolomic" effects and then to discuss the principles that guide nutrition of IUGR children in the light of these
Isolated 'sign of the horns': A simple, pathognomonic, prenatal sonographic marker of Crisponi syndrome
No full textThe case of a patient presenting with Crisponi syndrome recently hospitalized at our institution is described. During pregnancy a diagnosis of this syndrome was hypothesized following sonographic observation of the fetus with the hands showing the sign of the horns. Such a finding, if isolated, as in our case, may represent a simple, pathognomonic sonographic marker of Crisponi syndrome
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