1,721,041 research outputs found
Serum ALT level, phlebotomy treatment and alpha-interferon therapy in chronic hepatitis C.
No full textCapitolo 31 "Malattia di Wilson ed emocromatosi", in Sezione V "Malattie del fegato"
No full textDefinizione, epidemiologia, eziopatogenesi, clinica, diagnosi e terapia dell'emocromatosi e della malattia di Wilson
Diagnostic value of 24 hr urinary copper excretion after penicillamine challenge in the adult Wilson's disease patients.
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Capitolo 8 "Epatopatie da accumulo: malattia di Wilson ed emocromatosi", in Sezione I "Epatiti acute e croniche"
No full textRassegna delle diverse forme di emocromatosi ereditaria, illustrandone i principali elementi di sospetto e di diagnostica differenzial
HBV and HCV infections in Wilson's disease patients: Copper overload could be protective?
No full textQuality of life and psychiatric symptoms in wilson's disease: The relevance of bipolar disorders
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HFE gene mutations and Wilson's disease in Sardinia
No full textBACKGROUND:
Hypocaeruloplasminaemia can lead to tissue iron storage in Wilson's disease and the possibility of iron overload in long-term overtreated patients should be considered. The HFE gene encodes a protein that is intimately involved in intestinal iron absorption.
AIMS:
The aim of this study was to determine the prevalence of the HFE gene mutation, its role in iron metabolism of Wilson's disease patients and the interplay of therapy in copper and iron homeostasis.
METHODS:
The records of 32 patients with Wilson's disease were reviewed for iron and copper indices, HFE gene mutations and liver biopsy.
RESULTS:
Twenty-six patients were negative for HFE gene mutations and did not present significant alterations of iron metabolism. The HFE mutation was significantly associated with increased hepatic iron content (P<0.02) and transferrin saturation index (P<0.03). After treatment period, iron indices were significantly decreased only in HFE gene wild-type.
CONCLUSIONS:
The HFE gene mutations may be an addictional factor in iron overload in Wilson's disease. Our results showed that an adjustment of dosage of drugs could prevent further iron overload induced by overtreatment only in patients HFE wild-type
Short-term effect of treatment with oral DL-carnitine and intravenous L-carnitine in chronic uremia patients undergoing hemodialytic therapy
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