1,720,975 research outputs found
Calcium ethylenediaminetetraacetate toxicity in the rat: ultrastructural effects on skin collagen.
No full textThe effect of calcium ethylenediaminetetraacetate (CaEDTA) i.v. infusion on skin ultrastructure was studied in the rat with the aid of transmission electron microscopy. High magnification electron micrographs of collagen fibrils were analysed with a computer aided image analyser, in terms of the Gaussian distribution of fibril diameter and the distance between cross striations of collagen fibrils (D-spacing). CaEDTA caused marked depletion of collagen fibrils in the skin. The collagen fibrils from CaEDTA treated rats exhibited significant increases in D-spacing (about 30%) and diameter (about 40%) compared to saline treated controls. These findings are consistent with earlier published biochemical data indicating that CaEDTA enhances collagen degradation in the rat
Age and sport performance: Comparison of young and master amateurs participating in half-marathons.
No full textA role of the TRAIL-TRAIL receptor system in the pathogenesis of diabetes.
No full textThe TNF-alpha super-family of cytokines comprises structurally related proteins that play pivotal roles in regulating cell death, immune response and inflammation. A new member of the family namely Tumor necrosis factor alpha-Related Apoptosis-Inducing Ligand (TRAIL) is involved not only in apoptosis and immune regulation, but also it has a provocative role in vascular biology as reported recently. In this report we provide evidence that this new function of TRAIL may have a significance in the pathogenesis of diabetes and in particular in the vascular alterations that occur late during the natural history of the illness. Noteworthy, depending on the type of diabetes and on the disease stage, TRAIL can have a dual role, either as immune modulator as well as a regulatory molecule of the vascular wall fitnes
Heart rate at rest and during submaximal demanding effort in experienced, well-trained, aged oarsmen.
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Testosterone, prolactin and cortisol responses to scuba diving in a siphon at bottom of an alpine 700 m deep cave: a case report.
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