1,721,055 research outputs found
To be or not to be resilient in familial hypercholesterolaemia: implications for the management
No full textMetabolomic approach to foetal and neonatal heart
No full textMetabolomics is an emerging and powerful technology that provides an accurate and dynamic picture of the phenotype of mammalian systems through the study of endogenous and exogenous metabolites in their tissues or body fluids. In the last 10 years, an increase in the number of papers about metabolomics applied to cardiovascular risk factors and diseases has been observed. Anyway, the majority of these studies involved adult patients. In this article, all the up to now examples of metabolomics applied to the study of cardiovascular physiology, disease onset and progression during foetal and neonatal life have been reviewed. An outlook of the requirements for future researches has been also discussed
Gender-specific aspects in primary and secondary prevention of cardiovascular disease
No full textGender differences in biological substrates of disease determine different clinical manifestations of CV disease with importantimplications for prevention, diagnosis and therapy in the two sexes.In women, the activity of sex hormones reduces the influence of CV risk factors during the reproductive age, and delays the onset ofCHD of 2 decades compared to men. However, women as men suffer from CV events, and in women mortality from all CV causes andhave a greater than the sum of the others 7 causes of death together. Women are more likely than men to die of a first myocardial infarctiona probability of developing heart failure or a second infarction than their male counterparts. The levels of lipid components vary in different ages of life and in the two genders. TC and LDL increase in men between 35 and 50years of age. On the contrary LDL levels do not change significantly in fertile women in which they have a lower predictive value forCHD than in men, HDL levels are higher in premenopausal women than in men of the same all age and their role in predicting CHD isconsiderably higher in women. High triglycerides and Lp(a) are more important as a risk factor in women than in men.Because of the greater incidence of cardiovascular diseases in men until the early 80s, information about the importance of risk factorsassociated with an increased risk of cardiovascular events has been gathered mainly in men and transferred to women. Most studies onlipid-lowering therapy did not have the adequate statistical power to show significant reductions in CV events in women. Regarding theindications for use of statins in daily practice, current data suggest that in secondary prevention statins are equally effective in both genderswhile in primary prevention the CV benefits from lipid-lowering therapy in women are less clear than in men and therefore shouldbe used according to the degree of risk calculated from the available score systems
Effect of hormone replacement therapy on exercise capacity in healthy postmenopausal women
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Effect of hyperuricemia upon endothelial function in patients at increased cardiovascular risk
No full textEarly contractility impairment during anthracycline treatment revealed by serial tissue Doppler echocardiography in presence of negative biochemical markers
No full textSex differences in congenital heart defects and genetically induced arrhythmias
No full textSex medicine can be applied to define the effect of male or female sex-associated differences on the prevalence of congenital heart defects (CHDs), on clinical manifestation of the latter, on means of dealing with the defects and facing consequent surgical treatment, as well as on the success of surgery. The widespread use of modern databases has undoubtedly enhanced the possibility of these observations compared to the past, when findings were limited to case series from single cardiology or paediatric heart surgery units. The aim of the present review is to assess all publications present in the literature on sex differences and CHD, placing particular emphasis on both contradictory aspects and less acknowledged issues. Furthermore, a section of the review is devoted to the effect of sex differences on cardiac arrhythmias, particularly the largely genetically predetermined electrophysiological differences observed between men and women
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