1,720,992 research outputs found
The effects of antipsychotic treatment on cerebral structure and function in schizophrenia.
No full textSubjective cognitive imparments in schizophrenia patients: clinical and neuropsychological correlates.
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L'importanza della prevenzione delle ricadute nel trattamento a lungo termine della schizofrenia : efficacia dei farmaci antipsicotici.
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Subjective experience of schizophrenic patients treated with antipsychotics: clinical and pharmacological correlates
No full textAntipsychotics, antidepressants, anticonvulsants, and placebo on symptom dimensions of borderline personality disorder: a meta-analysis of randomized controlled and open-label trials
No full textBrain morphology in first-episode schizophrenia: a meta-analysis of quantitative magnetic resonance imaging studies.
No full textBackground: A number of meta-analytic reviews of structural brain imaging studies have shown that multiple subtle brain abnormalities are consistently found in schizophrenia. However, quantitative reviews till now published have included mainly studies performed on chronic schizophrenic patients but have failed to provide clear information on specific, possibly different,
findings in first-episode schizophrenia.
Methods: We performed a systematic search for MRI studies that reported quantitative measurements of volumes of brain regions in first-episode schizophrenic patients and in healthy controls. Twelve meta-analyses were performed for 6 cerebral regions.
Results: Twenty-one studies were identified as suitable for analysis. Significant overall effect sizes were demonstrated for lateral and third ventricular volume increase, and for volume reduction of whole brain and hippocampus, but not for temporal lobe, amygdala and total intracranial volumes.
Conclusions: The available literature data strongly indicate that some brain abnormalities are already present in first-episode schizophrenic patients. However, unlike the results of published meta-analyses conducted primarily on samples of chronic schizophrenic patients, the present study did not confirm a significant reduction of temporal lobe or amygdala volumes in firstepisode
schizophrenia. These findings support the hypothesis of different patterns of involvement of various cerebral areas over the time course of schizophrenia
Gray matter, white matter, brain, and intracranial volumes in first-episode bipolar disorder: a meta-analysis of magnetic resonance imaging studies
No full textObjectives: To perform a comprehensive quantitative analysis of the existing magnetic resonance imaging (MRI) studies of the brain conducted on patients with first-episode bipolar disorder (BD).
Methods: A systematic search was performed of MRI studies that reported quantitative measurements of brain volumes of first-episode bipolar patients and healthy controls. Four meta-analyses were performed for four cerebral regions.
Results: Significant overall effect sizes were demonstrated, with a reduction detected in patients with BD for total intracranial and white matter volumes, but not for gray matter and whole brain volumes.
Conclusions: The available MRI literature indicates that specific structural brain abnormalities are already present in first-episode bipolar patients. These do not overlap with those emerging from previous meta-analyses performed in patients with chronic BD. These findings support the hypothesis of different patterns of changes in brain morphology over the time course of bipolar disorder
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