1,721,113 research outputs found
The central role of immunity in the symbiotic event referred as parasitism
No full textSeveral papers have been published on the communications between species, including host-parasite and predator-prey interactions. Here we stress the crucial role of immune system in symbiosis and parasitism. In particular, it appears that during the coevolution between any interacting populations the immune system was selected accordingly to a flexible strategy in order to adapt itself to the needs of the homeostasis, thus allowing the evolution of symbiotic relationships
Oligomycin A and the IPLB-LdFB insect cell line: actin and mitochondrial responses.
No full textOligomycin A, an inhibitor of mitochondrial ATP synthase, provokes simultaneous and different responses in IPLB-LdFB insect cell line. The oligomycin A treatment causes mitochondrial loss, increase in reactive oxygen species (ROS), destabilization/reorganization of the actin microfilaments and, finally, autophagic cell death. We speculate that oligomycin A affects the mitochondria and that the impairment of these organelles leads to the generation of ROS in quantities that exceed the antioxidant capacity of the cell. This in turn would lead to a feedback loop of increased mitochondrial impairment, amplification of ROS production and the removal of damaged organelles through autophagy
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