826 research outputs found
Manoj Das An Incredible Bridge between Literature and Philosophy
No full textAttempts have been taken here to unveil the versatile virtuosity and artistry of Manoj Das especially in his literary attempts which walk with an incredible alliance with philosophy underneath the literary vesture. Apart from philosophical facet another significant dimension of his literature is 'psychology', which has well been analyzed here in this article. His c onsciousness about history, psychology and philosophy makes his literature more special. Special care has been taken in order to unveil his art of arresting the attention of readers while reading his text and afterward. Manoj Das' literature is more refined and alert due to his second persona. It has been demonstrated here with some concrete proofs. He is simply a magician in telling tales. He discovers diamond in dust, life in lifeless and cultural consciousness in the thalli of inorganic and organic objects. Another major aspect of his literary approach is the psychological dimension which covers the psychology of the involved character as well as of the readers. In short, his writings have that much potency to arrest the attention of the readers of his story. Another thing with regard to this phenomenon is his ability to convince and kidnap the readers' mind magically with his literary style and approach. Shri Das is culturally, socially, aesthetically, politically, philosophically, psychologically, historically and above all from the humanitarian viewpoint a conspicuously conscious story teller of the time. Dr. Santosh Kumar Nayak "Manoj Das: An Incredible Bridge between Literature and Philosophy" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-3 | Issue-4 , June 2019, URL: https://www.ijtsrd.com/papers/ijtsrd23866.pd
Risk Assessment of Genotoxic Impurities in Drug Substances
No full textAbstract: This article is a review paper, based on a Literature survey to define the Genotoxic impurities present in the drug substances and drug products. Article describes the definition of Genotoxic impurities, ssources of Genotoxic impurities, formation during manufacturing or on storage and classification based on their toxicity. This article also gives the various regulatory guidelines to control the Ggenotoxic impurities in drug substances. It also explains the Isolation, qualification of impurity and its characterization with quantification by the various analytical methods.
Keywords: Drug substance, Active pharmaceutical ingredients (API), Impurities, Genotoxic, classification, Guideline, toxicological concern (TTC) etc.
Title: Risk Assessment of Genotoxic Impurities in Drug Substances
Author: Santosh Kumar Amarbahadur Singh
International Journal of Mathematics and Physical Sciences Research
ISSN 2348-5736 (Online)
Vol. 10, Issue 1, April 2022 - September 2022
Page No: 6-13
Research Publish Journals
Website: www.researchpublish.com
Published Date: 23-May-2022
DOI: https://doi.org/10.5281/zenodo.6572606
Paper Download Link (Source):
https://www.researchpublish.com/papers/risk-assessment-of-genotoxic-impurities-in-drug-substancesInternational Journal of Mathematics and Physical Sciences Research, ISSN 2348-5736 (Online) , Research Publish Journals
Website: www.researchpublish.co
A Study on Sectionalizing and Coordination of Protective Devices and Voltage Drop Compensation of Rural Distribution System
No full textThis thesis is submitted to the Department of Electrical and Electronic Engineering, Bangladesh Institute of Technology (BIT), Khulna in partial fulfillment of the requirements for the degree of Master of Science in Engineering, May, 2002.Cataloged from PDF Version of Thesis.Includes bibliographical references (pages 172-173).Methodologies are presented in this thesis to study the coordination among the protective
devices and voltage drops at different points of a radial distribution system. Maximum
and Minimum values of currents due to different types of faults occurring at various
points of the distribution system are calculated. The inverse time relays and fuses are
modeled by nonlinear time current relations. The definite time relays are modeled by
constraint conditions. Impedance model for the radial distribution system is considered to
find the fault currents. The effectiveness of the protection scheme is studied using
different sets of minimum and maximum values of fault currents for all concerned fuses
and relays acting as primary and backup protective devices. In the case of any
miscoordination or improper coordination the CT plug multiplier setting and relay time
dial setting are proposed to adjust. The optimal coordination of the radial distribution
system is calTied out using two- phase technique. In phase I, the constraints for protecting
the lines and equipment of the distribution system for primary and back up protection is
tested for feasibility of the constraint conditions for protection. In this phase the relay and
fuse time-current characteristic curves arc superimposed to visualize and ensure
coordination graphically. Phase II endeavors to find out the optimal settings of relays to
ensure minimum power interruption. Voltage drops under specified loading at different
points are calculated to have an idea about the condition of power at different distribution
points of the feeder. As case study, the radial distribution feeders of the Topshidanga
33/11 KV S/S and the Baganchra 33/11 KV S/S, under Jessore PBS-I, a project of Rural
Electrification Board is considered for study on sectionalizing and coordination of
protective devices and voltage drop compensation. The proposed methodology is tested in
a Pentium III PC-based digital computer environment.Santosh Kumar DasMaster of Science in Engineerin
Improving the efficacy of bacillus calmette guerin vaccine by concomitant inhibition of T regulatory and T helper 2 cells.
No full textDoctor of Philosophy in Medical Microbiology. University of KwaZulu-Natal, Medical School 2015.Tuberculosis (TB) remains a major threat to human population as currently Mycobacterium tuberculosis (MTB) infects nearly 33% of the global population. Annually, about one and a half million deaths are caused by tuberculosis (TB). Current reports suggest that approximately nine million new TB cases are reported every year. There is an available therapy for TB, however it is quite lengthily and consists of numerous antibiotics leading to treatment dropout. This treatment incompletion has been linked to the major cause for the appearance of drug-resistant species of MTB. Consequently, alternate therapies to treat TB are needed. Bacillus Calmette-Guerin (BCG) remains the only vaccine of choice since its inception in 1921. Although BCG mounts host protective T helper1 (Th1) cell activation, which plays a pivotal role in host protection against TB, its efficacy is inadequate, suggesting that additional methods to enhance protective immune responses are needed. We have also shown that simultaneous inhibition of Th2 cells and Tregs by using pharmacological inhibitors (suplatasttosylate and D4476, respectively) dramatically enhance MTB clearance and induces a superior Th1 response. Here we show that treatment with these two immuno-modulators during BCG vaccination dramatically improves vaccine efficacy. Furthermore, we demonstrate that these drugs induce a shift in T cell memory development, towards central memory T (Tcm) cell responses. Collectively, our findings provide evidence that concurrent inhibition of T helper cells type 2 and Tregs during BCG vaccination promotes vaccine efficacy
N→π* non-covalent interaction is weak but strong in action
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Previous issue date: 6n* interaction is a newly discovered non-covalent interaction which involves delocalization of lone pair (n) electrons of an electronegative atom into * orbital of a carbonyl group or an aromatic ring. It is widely observed in materials, biomolecules (protein, DNA, RNA), amino acids, neurotransmitter and drugs. However, due to its weak strength and counterintuitive nature its existence is debatable. Such weak interactions are often masked by solvent effects in condense phase or physiological conditions thereby, making it difficult to prove the presence of such weak interactions. Therefore, we have used isolated gas phase spectroscopy in combination with quantum chemical calculations to study n* interaction in several molecules where, our molecular systems are free from solvent effects or any external forces. Herein I will be discussing two of the molecular systems (phenyl formate and salicin) where, we have observed the significance of n* interaction in determining the conformational specificity of the molecules. We have proved the existence of n* interaction for the first time through IR spectroscopy by probing the carbonyl stretching frequency of phenyl formate. Our study is further pursued on a drug named salicin where, we have observed that its conformational preferences is ruled by n* interaction even though a strong hydrogen bonding interaction is present in the molecule. Our results show that n* interaction, in spite of its weak strength, should not be overlooked as it existence can play an important role in governing the structures of molecules like other strong non-covalent interactions do
CHANGES IN THE QUALITY OF DRESSED CHICKEN OBTAINED FROM DIFFERENT SOURCES DURING FROZEN STORAGE
No full textThis present study examines the preservation quality of dressed chicken procured from
different sources of processing during storage at –18±1ºC. Breast portion of the dressed birds obtained
from three different sources, viz. market/road side slaughtered chicken (MSC), retail slaughtered
chicken (RSC), and scientifically slaughtered chicken (SSC), were cut into chunks, divided into 250 g
portions, packed in polyethylene bags, stored at –18±1ºC and evaluated at 30 days intervals for changes
in quality attributes. Frozen storage had no marked influence on pH change of the samples. SSC
samples had higher extract release volume (15.34±0.08 to 13.45±0.93 ml) than MSC (13.00±0.19 to
9.91±0.97 ml) and RSC samples (13.65±0.24 to 11.70±1.21ml). There was significant increase (P<0.05)
in thiobarbituric acid of all three sample types during storage but values were well below the threshold
level of spoilage. SSC samples showed lower tyrosine content throughout frozen storage compared to
MSC and RSC samples. A significant decline in microbial load, viz. total viable count, coliform count,
psychrophilic count and yeast and moulds count were noticed during frozen storage. Organoleptic
attributes, viz. appearance, flavour, texture and overall palatability were not affected due to frozen
storage except juiciness in MSC samples which decreased (P<0.05) from 6.53±0.13 to 5.96±0.11 on 90
days of storage. Although the scientifically slaughtered chicken had better quality, all the sample
types could be stored at –18±1ºC till 90 days without much deterioration in their quality
Author Productivity and the Application of Lotka\u27s Law in the Field of Horticulture
No full textCitation study of 10,845 citations appended to 80 doctoral dissertations in the field of horticulture awarded by Bidhan Chandra Krishi Viswavidyalaya (BCKV), Mohanpur and Uttar Banga Krishi Viswavidyalaya (UBKV), Cooch Bihar, West Bengal has been carried out to determine the authorship pattern and productivity to cited articles during 1991-2010. The study revealed that researchers are mainly used journal articles 8437 (77.796%). Generally Loka’s law describes the frequency of publications by authors in a given subject/ discipline. In this paper, an attempt has been made to study the applicability of the Lotka’s law to the publications of horticulture scientists in BCKV and UBKV. A Kolmogorov-Smirnv (K-S) test has been conducted to find out as to what extent, the author productivity conforms to the Lotka’s law. But this test is applied for the fitness of Lotka’s law does not fit to the horticulture literature
Smart Cities in India:A Bibliometric Analysis
No full textSmart cities have attained global popularity in the last decade. The present study attempts to find the trends of smart city research in India by exploring existing literature on this theme. Year-wise, author-wise, citation-wise, affiliation-wise, keywords-wise, country-wise and source-wise listing of literature are the parameters to conduct present study. Bibliometric method on Scopus database is employed. The research focus was determined by keyword co-occurrence using VOSviewer.</p
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