219 research outputs found
Un poeta ritrovato Posidippo di Pella.
No full textDonnet Daniel. Un poeta ritrovato Posidippo di Pella.. In: L'antiquité classique, Tome 73, 2004. p. 333
Proyecto de dos viviendas pareadas en parla. Opción A
No full textCódigo de proyecto: AQT 10S08Daniel López Pella ; director de proyecto: Bárbara Serrano PérezCurso 2010-2011Arquitectura Técnica (AQT)Escuela Politécnica Superio
Marsyas of Pella and Phrygia
No full textThere is a lot of uncertainty about the attribution of fragments to either Marsyas of Pella or Marsyas of Philippi. This paper challenges the traditional attribution of BNJ 135–136 F 4 (mentioning Midas’chariot with the Gordian knot) to Marsyas of Philippi and argues in favor of the identification of Marsyas of Pella as the author. For ideological and propagandistic reasons, it would fit well into Marysas of Pella’s account of the roots of Argead rule in his first book. By referring to Midas, Marsyas would have been able to link his half-brother Antigonus as the contemporary governor of Phrygia not only with the legendary Phrygian king and his legacy, but also with a Macedonian logos attested by Herodotus, creating a connection between Midas and the foundation of Argead rule. According to this logos, there existed old kinship relations between Macedonians and Phrygians who used to dwell at the foot of Mt. Bermium and were called Briges. This tradition was of propagandistic value and could have served to increase the ideological value of Antigonus’satrapy and main base in the rivalry with the other Diadochs
Vespasian V. Pella: International Criminal Justice As A Safeguard Of Peace, 1919-1952
No full textVespasian V. Pella was an early twentieth century Romanian jurist who conceived and championed a system of international criminal justice that was designed to prevent war, punish atrocity, and vindicate humanity’s political and economic rights. He argued that governments had a duty to prevent economic dislocation as well as criminal acts capable of undermining international order. To construct these safeguards, Pella promoted the unification of domestic criminal law and the incorporation of international norms into domestic law. He also argued that an assembly of nations and an international criminal tribunal should play a subsidiary role by resolving disputes, imposing sanctions, and punishing aggression and violations of the laws of war. According to Pella, these institutions were necessary safeguards against the root cause of aggressive war—a small, disciplined, and ideologically rigid cadre of men who threatened to use the power of the state to manipulate the public into war. In this chapter we will excavate the ideas, people, and events that shaped Pella’s politics—the influence of his parents, the role of republican, pacifist, and socialist ideals, his desire to understand the psychological reactions of individuals and crowds, as well his response to the atrocities of the First World War. It was these atrocities that ultimately led Pella to dedicate his life to advancing what he called the “international criminal law of the future.” He did so through his scholarship, his diplomacy, and above all, through his advocacy in the organizations such as the Association International de Droit Pénale and the Bureau International pour l’Unification du Droit Pénal. In a relatively short period, Pella forged a professional consensus on previously controversial questions such as universal jurisdiction and corporate criminal liability. Yet though his ideas made great strides within the legal profession, the political support necessary to bring his system to life never materialized, either before or after the Second World War. We will examine the obstacles that Pella encountered and the underlying values of his project. Finally, the chapter challenges and overturns the many misconceptions about Pella that have proliferated in recent years and calls for further research into his life and work.First author draf
Extended consensus on blood pressure variability beyond blood pressure for management of hypertension
No full text[no abstract available
Adaptación y rendimiento de seis variedades de brócoli (Brassica oleracea var. italica) en el distrito de Yanahuanca
No full textRESUMEN
El presente trabajo de investigación se realizó en el fundo Tinyacu de la localidad de Yanahuanca, provincia Daniel Alcides Carrión, región Pasco en condiciones de campo. Los objetivos de la investigación fueron: Determinar que variedad o variedades de Brócoli (Brassica oleracea var. Itálica) se adaptan y presentan alto rendimiento en condiciones de Yanahuanca-Pasco. Determinar la precocidad y las características agronómicas de las variedades en estudio. Por lo tanto, se estudiaron seis variedades de alta calidad Tiburón, Coronado, Batavia, Almanor, Monaco y Legacy, el diseño estadístico utilizado fue de bloques completos al azar con seis tratamientos y tres repeticiones, para la fertilización del cultivo se realizó análisis de suelo y se obtuvieron datos meteorológicos del ministerio de agricultura. Los resultados fueron los siguientes: las variedades que se adaptaron mejor y presentaron mayor rendimiento son Monaco y Legacy con 22.326 y 22.203 t/ha respectivamente; en cuanto a las características agronómicas como número de hojas, altura de planta, diámetro de inflorescencia, número de floretes y peso de pella, las variedades que sobresalieron fueron Almanor, Legacy y Monaco. Así mismo la variedad Legacy es la más precoz con 91 días a la madurez después del transplante y la más tardía fue la variedad Tiburón con 109 días después del transplante.
Palabras clave: brócoli, adaptación, rendimiento, variedades.Tesi
Synthesis and applications of caged thiols for studying protein prenylation.
No full textUniversity of Minnesota Ph.D. dissertation. February 2012. Major: Chemistry. Advisor: Dr. Mark D. Distefano. 1 computer file (PDF); xxi, 106 pages.Ras proteins are a subfamily of small GTP-binding proteins that are involved in various critical cellular processes including cell growth, survival and nuclear transport. It has been reported that roughly 30% of human cancers are derived from mutations of Ras, and prenylation is a key step that activates their oncogenicity. Commercial inhibitors of prenylation have been successful at arresting Ras activation and can be categorized into two families: farnesyltransferase inhibitors (FTIs) and geranylgeranyltransferase inhibitors (GGTIs). The focus of this thesis is to explore the use of photoremovable protecting groups (caging groups) to better understand the process of prenylation by caging the critical thiol residues of FTIs, GGTIs and peptides.
The caging group bromohydroxy coumarin (bhc) was covalently bound to the thiol of the FTI L-744,832 in order to inactivate the inhibitor. This caged FTI was evaluated with respect to its one- and two-photon uncaging kinetics and ability to release FTI upon photolysis. Analysis shows that bhc photolysis occurs more rapidly compared to the most frequently used family of nitrobenzyl-based cages, and that FTI is produced with good yields upon one- and two-photon excitation. Bhc-FTI was then tested on different cell lines in order to show that upon irradiation FTI is released that inhibits Ras farnesylation (observed via Western blot analysis), Ras membrane localization (detected by confocal microscopy), and downstream signaling (fibroblast morphology).
This same approach was utilized to cage FTI with bromohydroxy quinoline (BHQ). The covalent inactivation of FTI with BHQ was employed to cage the active site thiol (BHQ-FTI) and active site amine (BHQ-FTI urethane). Kinetic evaluation suggests that BHQ-FTI uncages faster than bhc-FTI but it produces little FTI upon photolysis due to the formation of unreactive photoproducts. Despite its poor yield, one photon cell experiments with BHQ-FTI resulted in the inhibition of Ras farnesylation, Ras membrane localization and downstream signaling. Quantitation and biological experiments with BHQ-FTI urethane are ongoing.
Peptides that are substrates of protein farnesyltransferase (PFTase) were caged with bhc and BHQ at their crucial thiol that is targeted for farnesylation. Upon one-photon photolysis peptides caged with BHQ show poor yields of free peptide while bhc-caged ones result in good peptide production. One of these caged peptides was subjected to an in vitro farnesylation assay to show that no farnesylation occurs, but upon one- and two-photon irradiation farnesylated peptide can be detected. Application of this caged peptide to study the mechanism of farnesylation via X-ray crystallography is under way.
Certain Ras proteins are alternatively geranylgeranylated and retain full function when farnesylation has been inhibited; as a result, GGTI-286 was caged with bhc to study this phenomenon. The synthesis of this GGTI and the inactivation of its thiol via covalent bonding with bhc is described here. The kinetic analysis of bhc-GGTI as well as its quantitation and biological testing are a work still in progress.Abate Pella, Daniel. (2012). Synthesis and applications of caged thiols for studying protein prenylation.. Retrieved from the University Digital Conservancy, https://hdl.handle.net/11299/121585
Respuesta del cultivo de col china (Brassica campestris var. pekinensis) a la aplicación de guano de murciélago en el distrito de Yanahuanca, Provincia de Daniel Carrión
No full textEl presente trabajo de investigación se realizó en el fundo denominado Marayniyog de propiedad del señor Rodolfo León Benavidez ubicado a 1 kilómetro del distrito de Yanahuanca. Los objetivos de la investigación fueron: Evaluar el efecto de diferentes dosis de guano de murciélago en el comportamiento agronómico de dos variedades de col chino. Comparar los rendimientos de los cultivares bajo la fertilización orgánica, el diseño estadístico utilizado fue de Bloques Completos al Azar, distribuidos en una factorial de 3x2 (tres dosis de guano de murciélago y dos variedades de col chino. Los factores en estudio fueron: dosis de 2,3 y 4 t/ha de guano de murciélago y las variedades de col chino y pack-choy, después de realizar los análisis respectivos se llegaron a las siguientes conclusiones: Las características agronómicas: Porcentaje de germinación largo de las hojas y diámetro de las pellas, no mostraron un efecto significativo en las diferencias causadas por los tratamientos en estudio. Mientras que las variables número de hojas, ancho de las hojas y peso de las pellas por planta. Mostraron significación entre sus promedios en los diferentes tratamientos. El Rendimiento: Peso de la pella por planta y el rendimiento total por ton en toneladas por hectárea, tuvieron un efecto significativo. El T2 (2t/ha; variedad Pack-choy) obtuvieron los mayores promedios con 1.93 kg/planta y 33.75 t/ha. Se recomienda. Realizar estudios complementarios siguiendo la línea de investigación para confirmar los resultados obtenidos diferentes épocas de siembra en cultivo de Brassica sinensis L. “col china”. Aplicar 2 t/ha de guano de murciélago en el cultivo de pack-choy por los altos rendimientos que se obtieneTesi
Efficacy and Safety of Treatment of Hypertensive Patients with Fixed Combination Perindopril/Indapamide Up to 10/2.5 mg
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