264 research outputs found
Pillar[n]arenes: towards higher yielding synthetic routes
No full textAn efficient templated approach for the synthesis of pillar[n]arenses (P[n]) bearing different alkoxy substituent has been developed. P[6] was obtained in high yield up to 38% with higher selectivity than P[5] thank to the use of small organic cation binding P[6] better than P[5] as templates
Synthesis, Mechanism and Catalytic Applications of Pillar[n]arenes
No full textPillar[n]arenes (P[n] n = 5-15) are a new class of macrocyclic arenes discovered for the first time by Ogoshi in 2008, which attracted a lot of attention due to their unique binding properties towards neutral electron poor compounds. Our research was focused on the enhancement of the yield of the larger macrocycle P[6], starting from three different alkoxy substituted benzene derivatives. Our synthetic approach involved the study of a series of small organic and organometallic cations in the role of a template, such as a cobaltocenium salt, ferrocenium salt, tetramethylammonium chloride and butyl methyl imidazolium salt.
Through mass spectroscopy we further investigated the reaction templated by the quaternary ammonium salt and promoted by the presence of FeCl3. We finally tuned the experimental conditions for the conversion of both P[5] and its oligomeric by-products into P[6].
Finally our group studied the catalytic effect of the presence of P[5] in nucleophilic substitution reactions, observing a rate acceleration between 10 and 20 times when the substrates were allyl halides and primary linear amines. This was the first example of the use of pillararenes as real organocatalysts
Il trattamento chirurgico delle metastasi epatiche da carcinoma colorettale: venti anni di esperienza
No full textVascularization of experimental liver metastases 3-the effect of hepatic artery ligation on blood flow
No full textPrognostic factors affecting long term outcome after liver resection for hepatocellular carcinoma.
No full textI.F. 3,632
Abstract: BACKGROUND. Long term results after liver resection for hepatocellular carcinoma (HCC) are disappointing because the disease tends to recur. In this study, the authors assessed prognostic factors affecting long term outcome, in the hope that these factors might be used in selecting HCC patients for surgery.
METHODS. During the period 1977-1995, 100 consecutive patients underwent curative liver resection; 78 of 100 had HCC arising on preexisting cirrhosis (53 Child's Class A and 25 Child's Class B). Thirty-five prognostic factors were evaluated for their association with overall survival (OS) and disease free survival (DFS) in univariate and multivariate analysis (Cox proportional hazards model).
RESULTS. There were four postoperative deaths. Seven patients died in hospital of hepatorenal failure: six had Child's Class B cirrhosis and had undergone preoperative chemoembolization. Of the remaining 89 patients, 50 developed recurrence. All surviving Child's Class B patients had recurrence. Five-year OS, postoperative deaths included, was 38% (median, 36 months). Five-year DFS, postoperative deaths excluded, was 26% (median, 21 months). Independent prognostic factors for DFS were Child's class, glutamic-oxaloacetic transaminase, gamma-glutamyltransferase, alpha-fetoprotein, number of tumor nodules, width of resection margins, preoperative chemoembolization, and experience of the team that performed the surgery. Factors with an independent effect on OS were Child's class and width of resection margins.
CONCLUSIONS. Liver resection can provide long term DFS in HCC patients with normal liver function, In patients with liver function impairment or an inadequate resection margin, recurrences are almost certain to occur. Preoperative chemoembolization significantly prolongs DFS but may increase the risk of postoperative liver failure in patients with Liver function impairment. (C) 1998 American Cancer Society
Colorectal metastases to the liver present results and future strategies.
No full textI.F. 0.499
Abstract: In recent years, wide agreement has been expressed on the value of surgical resection for liver metastases from colorectal cancer, while for unresectable patients different types of locoregional treatment have been attempted. One hundred seventy-one patients with hepatic metastases from colorectal cancer were treated by us over a period of 15 years. Sixty-four underwent hepatic resection, and 107 underwent various forms of locoregional treatment. Our experience confirms the opinion that hepatic resection can be performed with a "curative" aim in patients with colorectal liver metastases: a 5-year survival rate can be achieved in about 30% of resectable cases. Adjuvant chemotherapy after hepatic resection should be tested in prospective randomized trials. Patients with diffuse liver metastases can benefit from locoregional infusion chemotherapy. Symptoms improve in most patients and objective responses are higher than those reported for systemic chemotherapy. Survival benefit with respect to untreated patients, has not yet been demonstrated by prospective randomized studies. Future improvements may be achieved by using new treatment modalities, such as new drug combinations, repeat arterial ischemia, and local tumor destruction. As these types of treatment are still experimental they should be employed only in prospective clinical trials
Evaluation of cerebral perfusion after subarachnoid hemorrhage using transcranial Doppler and rCBF measurements
No full textno abstract availabl
Hepatic arterial infusion for unresectable liver metastases from colorectal carcinoma.
No full textI.F.: 0.40
Colorectal metastases to the liver: present status of management.
No full textI.F. 1.133
surgical resection for liver metastases from colorectal cancer, while for unresectable patients different types of locoregional treatment have been attempted. One hundred seventy-one patients with hepatic metastases from colorectal cancer were treated by us over a period of 15 years. Sixty-four underwent hepatic resection, and 107 underwent various forms of locoregional treatment. Our experience confirms the opinion that hepatic resection can be performed with a "curative" aim in patients with colorectal liver metastases: a 5-year survival rate can be achieved in about 30% of resectable cases. Adjuvant chemotherapy after hepatic resection should be tested in prospective randomized trials. Patients with diffuse liver metastases can benefit from locoregional infusion chemotherapy. Symptoms improve in most patients and objective responses are higher than those reported for systemic chemotherapy. Survival benefit with respect to untreated patients, has not yet been demonstrated by prospective randomized studies. Future improvements may be achieved by using new treatment modalities, such as new drug combinations, repeat arterial ischemia, and local tumor destruction. As these types of treatment are still experimental they should be employed only in prospective clinical trials
Prognostic factors affecting long term outcome after iver resection for hepatocellular carcinoma. Results in a series of 100 italian patients
No full text- …
