123 research outputs found
A systematic review of surgical biopsy for LCIS found at core needle biopsy - Do we have the answer yet?
No full textAbstract not availableE.S. Buckley, F. Webster, J.E. Hiller, D.M. Roder, G. Farshi
Do the benefits of screening mammography outweigh the harms of overdiagnosis and unnecessary treatment?
No full textYes. Public health adviser David Roder and Cancer Council Australia CEO Ian Olver believe the reduction in breast cancer mortality in Australia reflects both treatment and screening effects
Clinical and pathological factors predictive of lymph node status in women with screen-detected breast cancer
No full textCopyright © 2006 Elsevier Ltd All rights reserved.Two thousand one hundred and thirty five asymptomatic invasive breast cancers detected through screening mammography were analysed to identify predictors of lymph node involvement. Multivariable analysis indicated that predictors included larger tumour diameter, an infiltrating ductal or lobular histological type, multifocal disease, a palpable lesion, and a younger age at diagnosis. An association also was found between nodal involvement and the presence of an extensive in situ component (EIC). Grade was associated with nodal involvement as a univariate predictor. It would be more accurate for screening assessment clinics to use models for predicting nodal status that were customised to their own experience rather than generic models developed in other settings that related predominantly to symptomatic cancer. These models could assist clinical decision-making on axillary node dissection and give guidance to pathologists on numbers of tissue sections to examine.P.G. Gill, C.G. Luke and D.M. Roderhttp://www.elsevier.com/wps/find/journaldescription.cws_home/623010/description#descriptio
Uns brins de mossarabisme valencià
No full textThe author studies etymologically two Arabisms: roder, which he cosiders to be derived from rotair, not from rodar, and its synonym cullerat, often found in medieval Valencian texts
Detection by screening mammography is a powerful independent predictor of survival in women diagnosed with breast cancer
No full textCopyright © 2003 Elsevier Ltd. All rights reserved.Four hundred and sixteen invasive breast cancers, detected initially by mammography, were compared with 929 presenting symptomatically, all treated at a South Australian teaching hospital. Predictable differences included lower stages and grades, less vascular invasion and proliferative activity, and more hormone-receptor expression among the mammographically detected. Unpredicted differences included significantly higher survivals for mammographically detected cases throughout the 9 year follow-up period after adjusting for stage and the Nottingham Prognostic Index. In a multivariable analysis, differences in stage, grade, and hormone receptor expression accounted for only about half the survival advantage of mammographically detected tumours. Accounting for additional person and tumour characteristics had only a marginal effect on this result. This suggests that detection by mammography has independent favourable prognostic significance beyond that explained by conventional indicators. If confirmed, this finding would have important implications for the prognostic advice given to women and may merit further investigation into its underlying biological mechanisms.P.G. Gill, G. Farshid, C.G. Luke and D.M. Roderhttp://www.elsevier.com/wps/find/journaldescription.cws_home/623010/description#descriptio
Asindulum montanum Roder 1887
No full text<i>Asindulum montanum</i> Röder, 1887: 116. <p>Figs. 3–4, 38–50, 84</p> <p> <b>Types</b>. Syntypes, male & female, (MLUH), not examined: USA: NEW HAMPSHIRE, “ White Mountains (America borealis).”</p> <p> <b>Material examined</b>. CANADA: ALBERTA: McMurray, 10.VIII.1953, G.E. Ball, 1m (CNCI); BRITISH COLUMBIA: Liard Hot Springs, 23.VII.1987, M. Polak, 1m (CNCI); MANITOBA: Atikameg Lk, 14.VIII.1949, J.B. Wallis, 1f (CNCI); Teulon, 24.VII.1922, A.J. Hunter, 1m (CNCI); P.N. Vroom, Aweme, 12.VIII., 920, 1m (CNCI); NEW BRUNSWICK: Kouchibouguac N. P., D.B. Lyons, 9.VIII. 1978, 4m, 10.VIII. 1978, 2m 1f, 11.IX.1978, 1f (all CNCI); NOVA SCOTIA: Mount Uniacke, 5.VIII.1958, J. R. Vockeroth, 1f (CNCI); ONTARIO: (Renfrew) 1 km N of Griffith, at golden rod flowers in shade, 9.viii.1994, A.E. Stubbs, 1m (PCC); (Hastings) 4 km W of Maynooth, at golden rod flowers, 8.viii.1994, A.E. Stubbs, 1f (PCC); Ogoki, 2.VIII.1952, J.B. Wallis, 1f (CNCI); One Sided Lake, 1 Aug. 1960, S.M. Clark, 1f (CNCI); Algonquin Pk., 1f (CNCI); Carleton Place, 24.VII.1959, C.H. Mann, Idema Illustration, 1m (CNCI); Sudbury, 1m 1f (CNCI); SASKATCHEWAN: Wenoncha [Moose Mtn. Prov. Pk., 49° 49′ 59″ N, 102° 17′ 7″ W], 12.VIII.1925, K.M. King, 1f (CNCI); QUEBEC: King Mtn., Old Chelsea, 1000’, 5.VIII.1969, Malaise trap, D.D. Munroe, 5m 1f (CNCI); Masham Twp, Gatineau Co., 2.VIII.1974, D.M. Wood, 6m 3f (1m 1f SFC, 5m 2f CNCI); Duncan Lake, nr. Rupert, J.F. McAlpine, 1.VIII. 1969, 1m, 13.VIII. 1969, 2m, 2. V. 1971, 3m2f, 14.VIII. 1971, 5m, 19.VIII. 1971, 5m, 28.VIII. 1971, 3m 1f, 1.IX. 1971, 1m (all CNCI); Ste. Catherine, Cté Portneuf, 13–15.VIII.1971, D.M. Wood, 1m (CNCI); 4 mi. N. Eardley, D.M. Wood, 20.VIII.1971, 1f, 25.VIII. 1971, 1m 1f (all CNCI); Lac Mercier, 9.VIII.1937, G.S. Walley, 1m (CNCI); Parke Reserve, Kam. Co., 950’, 26 Aug. 1957, W. R. M. Mason, 1m (CNCI); Lac Brule, P.Q., 7.VIII.1945, O. Peck, 2m 1f (CNCI); Cascapedia, VIII.7.1954, J.E.H. Martin, 1f (CNCI); Old Chelsea, King Mt., 13.VIII.1969, B. V. Peterson, 1m (CNCI); Ste. Agathe des M, G.S. Walley, 5.VIII.1937, 1f, 7.VIII. 1957, 1m (all CNCI); Forestville, 11.VIII.1950, J. R. McGillis, 1f (CNCI); Laniel, H.S. Fleming, 1931, 10 Aug., 2m 2f, 15 Aug. 1m, 19 Aug., 1m 1f (all CNCI); Ft. Coulonge, 20.VII.1919, J.I. Beaulne, 1f (CNCI); USA: MAINE: York Co., West Lebanon, VII.31–VIII.6.1990, D.W. Barry, Malaise, 1m (DENH); MICHIGAN: Emmet Co., vii.7.1948, W. Porter, “compared with male lectotype of <i>Asindulum montanum</i> v. Röder, considered conspecific, Jean Laffoon 1952,” 1f (ISUI); MINNESOTA: Hubbard Co., “ Kabekena ” [probably Kabekona] City, Sec 32, T 143 N, R 33 W, vii.24.65, D.L. Deonier, 1f (ISUI); NEW HAMPSHIRE: White Mountains National Forest, 4 mi E of Benton, 1–4.viii.1980, A.E. Stubbs, 1f (PCC); White Mountains National Forest, 2 mi N of Stinson Lake, 9.viii.1980, A.E. Stubbs, 1m (PCC); Berlin, 26.VII.1930, C.A. Frost, 1f (CNCI); Carr Co., 2 mi. NW Wonalancet, D.S. Chandler, Malaise trap, VII.27–VIII.1.1984, 1m (DENH), VIII.2–10.1984, 2m 2f, (1m 1f DENH, 1m 1f SFC); Carr Co., The Bowl, 2.5 mi. NW Wonalancet, D.S. Chandler, Malaise trap, VII.27–VIII.1.1984, 2m, VIII.17–22.1984, 1m (all DENH); Coos Co., 7 mi. S. Errol, VIII.16.1985, J.F. Burger & W.J. Morse, 2m (DENH); Coos Co., Norton Pool, 2 mi. E. East Inlet, VIII.14.1984, Chandler & Burger, 5m 4f (DENH); Grafton Co., Benton, VIII.4.1984, W.J. Morse, 1f (DENH); Straf Co., 4 mi. W. Durham, R. M. Reeves, Malaise trap, VII.29–VIII.1.1982, 2m, VIII.2–5.1982, 3m, VIII.13–15.1982, 1m, VIII.23–26.1982, 1m, (all DENH); Straf Co., Spruce Hole, 3 mi. SW Durham, D. Chandler, Malaise, VII.24–VIII.6.1987, 1f, VIII.7– 20.1987, 2m, (all DENH); Straf Co., 1 mi. SW Durham, water tower, VII.24.1991, W.J. Morse, 1m (DENH); NEW MEXICO: F.M. Hull, Frank M. Hull Collection, C.N.C. 1973, 1m (CNCI); NORTH CAROLINA: Haywood Co., Pisgah Nat. Forest, Chestnut Bald, 5900’, 2.VIII1957, J.G. Chillcott, 1m (CNCI); Clingman’s Dome, Grt. Sm. Mt. Nat. Park, 6.VIII.1957, C.J. Durden, 6m (CNCI); Mt. Mitchell, 6800’, 12.VIII.1957, J.G. Chillcott, 3m (CNCI); Gr. Sm. Mt. Nat. Park Tenn., Clingman’s Dome, 6600’, 22.VIII.1957, J.G. Chillcott, 3m (CNCI); TENNESSEE: Gr. Sm. Mt. Nat. Park, Indian Gap to Clingman’s Dome, 5200–6600’, 6.VIII.1957, J.G. Chillcott, 6m (CNCI); Indian Gap, 23.VII.1957, W. R. Richards, 1m (CNCI).</p> <p> <b>Redescription</b>. Male. Body length ca. 6.5–9.0 mm (n = 2). Mouthparts as Figs. 3–4; long, about length of (or reaching just beyond) fore coxa. Thorax cream with three dark brown to black stripes on mesonotum (lateral stripes truncated anteriorly) that are sometimes entirely fused into a dark central area. Lateral portions of thorax with dark brown markings to mostly brown. Anterior spiracle without posterior setae. Legs cream, darkening to brown distally. Hind tibial trichia irregularly arranged. Wing 5.5–7.0 mm (mean = 6.6 mm, n = 10), often slightly brown fumose distally. CuP reaching wing margin. Abdomen with first three segments dark brown, fourth segment bright cream to orangish and usually brightest of all segments, remainder of segments orangish, brownish-orange, or rarely brown (Fig. 38). Male terminalia as Figs. 39–46. Male tergite 9 posteriorly medially emarginate, posterolateral corners developed into a pair of narrow, laterally-compressed, dorsally-hooked lobes. Ventrally, gonocoxites deeply and broadly medially emarginate with only a narrow strap connecting the two halves posteriorly (sometimes strap even narrowly divided medially). Lateral lobes of gonocoxites mitten-like, broadly rounded apically, dorsal edge with a short, dorsally-projecting, thumb-like lobe (dorsal process) dorsomedially. Gonostylus talon-like, apically-hooked and acute, with some strong subapical setae. Sperm pump (possibly fused with parameres?) complex, large and anteriorly elongated, with apodemes reaching into abdominal segments 6–5; notable are two pairs of very long, more laterally-positioned apodemes (one pair more ventral, one pair more dorsal) and an ejaculatory apodeme which is very strongly laterally compressed. The posterior apex of the sperm pump includes a pair of laterally flattened lobes that are dorsally connected, forming a U-shaped cradle.</p> <p>Female. As male except as follows: Body length ca. 7.0–10.0 mm (n = 2). Wing 7.0–9.0 mm (mean = 7.6, n = 9). Abdomen usually with first three segments dark brown, and remaining segments orange to orangish-brown, sometimes entire abdomen with slight orangish tinge (Fig. 50). Abdomen broader than in male and often slightly expanded and flattened posteriorly. Segments beyond tergite 7 strongly telescoped internally (even after maceration, female terminalia strongly retracted and virtually concealed from dorsal and ventral views). Female terminalia as Figs. 47–49. Cerci fleshy, setose, oval, pad-like. Sternite 10 notched posteriorly.</p> <p> <b>Diagnosis</b>. Both sexes with mouthparts ending near apex of fore coxa. Male tergite 9 with posterolateral corners developed into a pair of narrow (broad in <i>A. flavidum</i>), laterally-compressed, dorsally-hooked lobes. Female sternite 10 notched posteriorly.</p> <p> <b>Comments</b>. This species is, by far, the most common and widely distributed species of <i>Asindulum</i> in the Nearctic Region. The type series was not examined, but the original description (which indicates the combination of large size and abdomen that has abdominal tergites 1–3 black and the remainder yellowish) is adequate to rule out all species except for the dark color morph of <i>A. flavidum</i> which appears to be restricted to the southeastern USA and does not get as far north as the type locality of <i>A. montanum</i> in northern New Hampshire. Material has also been examined from the White Mountains of New Hampshire, which is listed as the type locality. A female specimen from Michigan was “compared with male lectotype of <i>Asindulum montanum</i> v. Röder [and] considered conspecific [by] Jean Laffoon [in] 1952,” (ISUI); this female also matches the concept of this species utilized herein.</p> <p> <b>Distribution</b> (Fig. 84). Specimens were examined from Canada (British Columbia, Alberta, Saskatchewan, Manitoba, Ontario, Quebec, New Brunswick, Nova Scotia) and USA (Maine, Michigan, Minnesota, New Hampshire, North Carolina, Tennessee, New Mexico). Additionally, Evenhuis (2006) records this species from USA: New Jersey, New York, Ohio, South Dakota, and Wisconsin.</p> <p> <b>Biology</b>. As listed in the Material Examined, two specimens from Ontario, Canada (PCC) were collected from golden rod flowers.</p>Published as part of <i>Fitzgerald, Scott J., 2023, The Nearctic species of Asindulum Latreille and Macrorrhyncha Winnertz (Diptera: Keroplatidae), pp. 72-106 in Zootaxa 5351 (1)</i> on pages 87-90, DOI: 10.11646/zootaxa.5351.1.3, <a href="http://zenodo.org/record/8391146">http://zenodo.org/record/8391146</a>
Uns brins de mossarabisme valencià
No full textAbstract: The author studies etymologically two Arabisms: roder, which he cosiders to be derived from rotair, not from rodar, and its synonym cullerat, often found in medieval Valencian texts
Dynamics and folding of single two-stranded coiled-coil peptides studied by fluorescent energy transfer confocal microscopy
No full textWe report single-molecule measurements on the folding and unfolding conformational equilibrium distributions and dynamics of a disulfide crosslinked version of the two-stranded coiled coil from GCN4. The peptide has a fluorescent donor and acceptor at the N termini of its two chains and a Cys disulfide near its C terminus. Thus, folding brings the two N termini of the two chains close together, resulting in an enhancement of fluorescent resonant energy transfer. End-to-end distance distributions have thus been characterized under conditions where the peptide is nearly fully folded (0 M urea), unfolded (7.4 M urea), and in dynamic exchange between folded and unfolded states (3.0 M urea). The distributions have been compared for the peptide freely diffusing in solution and deposited onto aminopropyl silanized glass. As the urea concentration is increased, the mean end-to-end distance shifts to longer distances both in free solution and on the modified surface. The widths of these distributions indicate that the molecules are undergoing millisecond conformational fluctuations. Under all three conditions, these fluctuations gave nonexponential correlations on 1- to 100-ms time scale. A component of the correlation decay that was sensitive to the concentration of urea corresponded to that measured by bulk relaxation kinetics. Thetrajectories provided effective intramolecular diffusion coefficients as a function of the end-to-end distances for the folded and unfolded states. Single-molecule folding studies provide information concerning the distributions of conformational states in the folded, unfolded, and dynamically interconverting states.Author manuscript. Published in final edited form as: Proc Natl Acad Sci U S A. 2000 November 21; 97(24): 13021-13026.The final published version of this article is located at: http://www.pnas.org/cgi/reprint/97/24/13021NIH GM54616; to William F. DeGradoNIH GM12592; to Robin M. HochstrasserNIH GM48130; to William F. Degrado and Robin M. HochstrasserThis work was supported by GM54616 (to W.F.D.), GM12592 (to R.M.H.) and GM48130 (to W.F.D. and R.M.H.) with instrumentation developed under RR01348. D.S.T. was supported by National Institutes of Health Grant NRSA F32-GM18589.Also available in PubMed Central. PMCID:PMC2717
High quality data are the key to understanding inequalities in cancer outcomes for Aboriginal and Torres Strait Islander Australians
No full textThe naval and military history of the wars of England [electronic resource] : including, the wars of Scotland and Ireland. In Which IS Given, An accurate and lively Description of the Sieges, Battles, Bombardments, Sea Engagements, Expeditions, and extensive Conquests of the British Arms, in all Quarters of the Globe. With A Variety Of Interesting and extraordinary Anecdotes of Military Skill and Intrepidity, heroic Adventures, brilliant Exploits, martial Atchievements, and memorable Actions of the British Warriors. Calculated To inspire the Rising Generation with Magnanimity and Virtue, and to Impress on their Minds the generous Ardour and Noble Emulation of their Ancestors. None But The Brave Deserve The Fair. ... . Ornamented With Elegant Copper-Plates.
No full textOriginally published in 186 parts, issued with 'The Britannic Magazine', 1793-1807, and bound in twelve volumes, each with a general titlepage.The author is named as "the late Thomas Mante" in vols. 7-8, which were completed by "an able and impartial hand".The imprint to vol. 5 begins: printed for the author, by J. W. Myers; vol. 6: printed for the author, by Lewis and Co.; vol. 7: printed for the proprietor by Lewis and Co.; and vol. 8: printed for the proprietor by Roder and Lewis, with a colophon: Lewis and Hamblin, printersThe plates are variously dated from 1795, and the final sentence of vol. 8 includes: "now (1807)".Electronic reproduction.English Short Title Catalog,Reproduction of original from British Library
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