242 research outputs found
sj-docx-1-aor-10.1177_00034894231179016 – Supplemental material for Rates of Antidepressant, Anxiolytic, and ADHD Medication Use Among Patients Undergoing ESS
No full textSupplemental material, sj-docx-1-aor-10.1177_00034894231179016 for Rates of Antidepressant, Anxiolytic, and ADHD Medication Use Among Patients Undergoing ESS by Alan D. Workman, Lillian W. Dattilo, Margaret B. Mitchell, Vinay K. Rathi and Neil Bhattacharyya in Annals of Otology, Rhinology & Laryngology</p
Drug discovery in advanced prostate cancer: translating biology into therapy
Get PDFCastration-resistant prostate cancer (CRPC) is associated with a poor prognosis and poses considerable therapeutic challenges. Recent genetic and technological advances have provided insights into prostate cancer biology and have enabled the identification of novel drug targets and potent molecularly targeted therapeutics for this disease. In this article, we review recent advances in prostate cancer target identification for drug discovery and discuss their promise and associated challenges. We review the evolving therapeutic landscape of CRPC and discuss issues associated with precision medicine as well as challenges encountered with immunotherapy for this disease. Finally, we envision the future management of CRPC, highlighting the use of circulating biomarkers and modern clinical trial designs
The Effect of Drugs and Other Compounds on the Ciliary Beat Frequency of Human Respiratory Epithelium
No full textBiologic therapies versus surgical management for aspirin‐exacerbated respiratory disease: A review of preliminary data, efficacy, and cost
No full textImbalance of World Heritage List: did the UNESCO strategy work?
Get PDFThe official intention of the UNESCO World Heritage List is to protect the global heritage. However, the imbalance of the distribution of Sites according to countries and continents is striking. Consequently, the World Heritage Committee launched the Global Strategy for a Balanced, Representative and Credible World Heritage List in 1994. To date, there have not been any empirical analyses conducted to study the impact of this strategy. This paper shows that the imbalance did not decrease and perhaps increased over time, thus reflecting the inability of the Global Strategy to achieve a more balanced distribution of Sites.UNESCO, international organizations, international political economy, global public goods, world heritage
Uintah High School Music Department at Tabernacle
No full textThe Uintah High School music department performed at the Uintah Tabernacle. Among the band are, Ellis Worthen, music teacher; unidentified, Brent Jones, Ellen Richardson, Onita Bastian, Arla Jones, Ilene Pope, Zele Postma, Catherine Evans, Sally Jones, Brenda O\u27Neal, Eleanor Marshall, Lloyd Winward, Helen Huff, Sue Ana Bilbey, Wayne Manwaring, Lorn Mansfield. Among the choir are Diane Searle, SueAnn Southam, Marie Dye, Kathy Despain, Terry Boren, Marie Peterson, Norlene Batty, Amy Lube, Pat Barlow, Margaret Olsen, Pat Marshall, D. J. Massey, Debra Curfew, Rhonda Simmons, LuRae Caldwell, Linda Pratt, Ora Fae Oviatt, Clara Jean Abplanalp, Linda Sharp, Renta Risner, Jean Oaks, Janey Vegil, Melody Thornehurst, Diane Abplanalp, Petra Scholfe, Janet Murray, Marilyn Southam, Darlene Helco, Linda Moritzky, Kathy Wallis, Kathy Warby, Cheryl Hardy, Leon Roberts, Robert Downard, Rex Jacobsen, Joe Davis, Alan McConkie, Calleen Brady, Phyllis Caldwell, Marquita Olsen, Louann Ross, Lela Hacking, Ann Albe, Barbara Henline, Peggy Henstreet, Janice Montgomery, Homer, Corbin, Kenneth Cooper, Richard Wedig, Mildred Mansfield, Leland Gotfredson, Bryan Purdy, Kent McCarrel, Larry Murray, Aaron, Thedell, Ron Pederson, David Hatch, Ken Workman, Russell, Pope, James Goodman, Steve Smuin, Terry, Bowthorpe, Shelley Stagg, Roland Searle, Bill Pope, Greg Hammond, Kim Spendlove, Ken Workman, Linda Swain, Narvene Winward, Linda Swain, Sherma Oaks, Connie Haws, Carol Southam, Judy Barton
Uintah High School Music Department at Tabernacle
No full textThe Uintah High School music department performed at the Uintah Tabernacle. Among the band are, Ellis Worthen, music teacher; unidentified, Brent Jones, Ellen Richardson, Onita Bastian, Arla Jones, Ilene Pope, Zele Postma, Catherine Evans, Sally Jones, Brenda O\u27Neal, Eleanor Marshall, Lloyd Winward, Helen Huff, Sue Ana Bilbey, Wayne Manwaring, Lorn Mansfield. Among the choir are Diane Searle, SueAnn Southam, Marie Dye, Kathy Despain, Terry Boren, Marie Peterson, Norlene Batty, Amy Lube, Pat Barlow, Margaret Olsen, Pat Marshall, D. J. Massey, Debra Curfew, Rhonda Simmons, LuRae Caldwell, Linda Pratt, Ora Fae Oviatt, Clara Jean Abplanalp, Linda Sharp, Renta Risner, Jean Oaks, Janey Vegil, Melody Thornehurst, Diane Abplanalp, Petra Scholfe, Janet Murray, Marilyn Southam, Darlene Helco, Linda Moritzky, Kathy Wallis, Kathy Warby, Cheryl Hardy, Leon Roberts, Robert Downard, Rex Jacobsen, Joe Davis, Alan McConkie, Calleen Brady, Phyllis Caldwell, Marquita Olsen, Louann Ross, Lela Hacking, Ann Albe, Barbara Henline, Peggy Henstreet, Janice Montgomery, Homer, Corbin, Kenneth Cooper, Richard Wedig, Mildred Mansfield, Leland Gotfredson, Bryan Purdy, Kent McCarrel, Larry Murray, Aaron, Thedell, Ron Pederson, David Hatch, Ken Workman, Russell, Pope, James Goodman, Steve Smuin, Terry, Bowthorpe, Shelley Stagg, Roland Searle, Bill Pope, Greg Hammond, Kim Spendlove, Ken Workman, Linda Swain, Narvene Winward, Linda Swain, Sherma Oaks, Connie Haws, Carol Southam, Judy Barton
Agroborealis, Vol. 18, No. 1 (July 1986)
No full textDirector's Letter -- Federal Support of Agricultural Research-A White House Perspective / Alvin L. Young -- Notice of Release of 'Nortran' Tufted Hairgrass / William W. Mitchell -- AFES Notes -- Use of a Plant Growth Regulator on Barley to Prevent Lodging / Ann J. Rippy and Frank J. Wooding -- Natural Selection May Modify Introduced White Clover Toward Superior Winterhardiness / Leslie J. Klebesadel -- Effect of Phosphorus and Potassium on Alsike Clover / Winston M. Laughlin, Glenn R. Smith, and Mary Ann Peters -- Plant-Parasitic Nematodes in Alaskan Soils / Ernest C. Bernard and Donald E. Carling -- Helping Your Greenhouse Help You / Lee Allen and Patrick Mayer -- Wintering Beef Cows on Alaskan Barley and Subsequent Selenium Status / Leroy Ben Bruce -- Feeding Tanner Crab Meal to Holstein Dairy Calves / Arthur L. Brundage -- Who's Planning Alaska? / Thomas J. Gallagher -- Cross-Country Skiers in Interior Alaska / W.D. (Bud) Rice and Alan Jubenville -- Amenity Values of Farmland / Steven D. Beasley and William G. Workman -- Publications List for 198
Understanding the effects of cattle grazing in English chalk streams
No full textAccounting for much of the landscape of southern England, chalk stream environments hold significant cultural, economic and ecological value. However, attempts to retain this value are often hindered by the remnants of historic management practices that have occurred across several millennia, as well as contemporary demands upon chalk stream amenity, including water abstraction, recreational use and fisheries management. One land-use that is believed to have a detrimental effect upon chalk streams, but which has been inadequately researched, is cattle grazing.Within this thesis the effects of cattle grazing in English chalk streams are assessed using a range of techniques. Terrestrial laser-scanning is employed to show that cattle can cause small, local changes in river bank topography. Direct and remote observations are used to link cattle behaviour to landscape utilisation, and a staticially significant correlation between air temperature and in-stream cattle activity is identified. Laboratory faecal analysis is conducted to establish the nutrient loading due to cattle, with results showing that cattle faeces contain signfiicant concentrations of phosphate. In-stream water turbidity monitoring is combined with remotely sensed cattle behaviour data to demonstrate that in-stream cattle activity has a minimal effect upon suspended sediment concentrations in an English chalk stream. A study using the diffuse fine sediment risk model, SCIMAP, highlights the hydrologically disconnected nature of English chalk streams, with model outputs concluding that topography, rather than land-use (cattle grazing), is the key control on diffuse fine sediment risk in English chalk streams.Combined, these individual findings provide a detailed, inter-disciplinary assessment that concludes the effects of cattle grazing in English chalk streams are different to those recorded in research from other environments, with physio-chemical effects (i.e. nutrient loading) being of greater significance than geomorphological agency (i.e. river bank destabilisation). This overarching conclusion has implications for the management of cattle grazing in English chalk streams, and these are discussed
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