34,349 research outputs found
[Telegram from E. D. Joost to Giles B. Cook - October 3, 1933]
No full textTelegram from E. D. Joost, secretary on behalf of Odelia R. Staiti, to the Reverend Giles B. Cook informing him of the passing of H. T. Staiti on Monday, October 2, 1933
The Impact of R&D Investment On Productivity - New Evidence Using Linked R&D-LRD Data
Get PDFThis paper uses confidential Census longitudinal microdata to examine the association between R&D and productivity for the period 1972.1985. These data allow for significant improvements in measurement and model specification, yielding more precise estimates of the returns to R&D. Our results confirm the findings of existing studies: 1) positive returns to R&D investment 2) higher returns to company-financed research 3) a productivity "premium" on basic research These results are robust to our attempts to adjust for "influential" outliers. Also, it appears that the return to company-financed R&D (but not total R&D) is an increasing function of firm size.
Discussion of: Outlier...s by R. J. Beckman and R. D. Cook
No full textThis issue was undated. The date given is an estimate.9 pages, 1 article*Discussion of: Outlier...s by R. J. Beckman and R. D. Cook* (McCulloch, Charles E.; Meeter, Duane) 9 page
Extrusion without a motor:a new take on the loop extrusion model of genome organization
Get PDFChromatin loop extrusion is a popular model for the formation of CTCF loops and topological domains. Recent HiC data have revealed a strong bias in favour of a particular arrangement of the CTCF binding motifs that stabilize loops, and extrusion is the only model to date which can explain this. However, the model requires a motor to generate the loops, and although cohesin is a strong candidate for the extruding factor, a suitable motor protein (or a motor activity in cohesin itself) has yet to be found. Here we explore a new hypothesis: that there is no motor, and thermal motion within the nucleus drives extrusion. Using theoretical modelling and computer simulations we ask whether such diffusive extrusion could feasibly generate loops. Our simulations uncover an interesting ratchet effect (where an osmotic pressure promotes loop growth), and suggest, by comparison to recent in vitro and in vivo measurements, that diffusive extrusion can in principle generate loops of the size observed in the data. Extra View on : C. A. Brackley, J. Johnson, D. Michieletto, A. N. Morozov, M. Nicodemi, P. R. Cook, and D. Marenduzzo "Non-equilibrium chromosome looping via molecular slip-links", Physical Review Letters 119 138101 (2017).</p
Marginally Restricted D-optimal Designs
Get PDF1 online resource (PDF, 16 pages)Cook, R. Dennis; Thibodeau, L. A.. (1987). Marginally Restricted D-optimal Designs. Retrieved from the University Digital Conservancy, https://hdl.handle.net/11299/199332
Entropy-driven genome organization
Get PDFDNA and RNA polymerases active on bacterial and human genomes in the crowded environment of a cell are modeled as beads spaced along a string. Aggregation of the large polymerizing complexes increases the entropy of the system through an increase in entropy of the many small crowding molecules; this occurs despite the entropic costs of looping the intervening DNA. Results of a quantitative cost/benefit analysis are consistent with observations that active polymerases cluster into replication and transcription “factories” in both pro- and eukaryotes. We conclude that the second law of thermodynamics acts through nonspecific entropic forces between engaged polymerases to drive the self-organization of genomes into loops containing several thousands (and sometimes millions) of basepairs
Personal Papers (MS 80-0002)
No full textLetter from Isaac H. Kempner to Everett R. Cook thanking for the check and mentions that he would return the check
tourr: An R Package for Exploring Multivariate Data with Projections
Get PDFThis paper describes an R package which produces tours of multivariate data. The package includes functions for creating different types of tours, including grand, guided, and little tours, which project multivariate data (p-D) down to 1, 2, 3, or, more generally, d (⤠p) dimensions. The projected data can be rendered as densities or histograms, scatterplots, anaglyphs, glyphs, scatterplot matrices, parallel coordinate plots, time series or images, and viewed using an R graphics device, passed to GGobi, or saved to disk. A tour path can be stored for visualisation or replay. With this package it is possible to quickly experiment with different, and new, approaches to tours of data. This paper contains animations that can be viewed using the Adobe Acrobat PDF viewer.
Personal Papers (MS 80-0002)
No full textTelegram sent by J. L. Cook to R. Lee Kempner offering sympathy on behalf of Federal Reserve Bank Branch after the death of D. W. Kempne
Dr. Samuel DuBois Cook, Interviewed by Dr. Barbara R. Hatton, August 21, 2012
No full textVideo interviews with a complementing monograph providing reflections of former presidents of Historically Black Colleges and Universities discussing leadership, mission, challenges, successes, and issues of race and education. Interviewer: Dr. Barbara R. Hatton, President, South Carolina State University 1992-1995, President, Knoxville College 1997-2005. Interviewee: Dr. Samuel Dubois Cook, President Dillard University 1974-1997
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