1,531 research outputs found
FIGURE 4. A. Galactia eriosematoides. B. Galactia glauscecens. C. Galactia heringeri. D. Galactia cordifolia. E in Synopsis of the genus Galactia (Phaseoleae, Papilionoideae, Leguminosae) in Brazil
No full textFIGURE 4. A. Galactia eriosematoides. B. Galactia glauscecens. C. Galactia heringeri. D. Galactia cordifolia. E. Fruit of Galactia cordifolia.Published as part of Ceolin, Guilherme B. & Miotto, Sílvia T. S., 2013, Synopsis of the genus Galactia (Phaseoleae, Papilionoideae, Leguminosae) in Brazil, pp. 1-26 in Phytotaxa 134 (1) on page 16, DOI: 10.11646/phytotaxa.134.1.1, http://zenodo.org/record/508607
FIGURE 3. A. Galactia decumbens. B. Galactia dimorpha. C. Galactia jussiaeana. D in Synopsis of the genus Galactia (Phaseoleae, Papilionoideae, Leguminosae) in Brazil
No full textFIGURE 3. A. Galactia decumbens. B. Galactia dimorpha. C. Galactia jussiaeana. D. Galactia peduncularis.Published as part of Ceolin, Guilherme B. & Miotto, Sílvia T. S., 2013, Synopsis of the genus Galactia (Phaseoleae, Papilionoideae, Leguminosae) in Brazil, pp. 1-26 in Phytotaxa 134 (1) on page 15, DOI: 10.11646/phytotaxa.134.1.1, http://zenodo.org/record/508607
FIGURE 4. A—D in Three new species of Convolvulaceae Juss. from South America
No full textFIGURE 4. A—D. Calystegia brummittii: A. Stem. B. Holotype. C. Inflorescence. D. Peduncle. E—G. Convolvulus ensifolius: E. Habit. F. Fruit. G. Stem. H—K. Ipomoea mirabilis: H. Habit. I. Inflorescence. J. Flower. K. Fruits.Published as part of Ferreira, Priscila Porto Alegre, Simão-Bianchini, Rosangela & Miotto, Silvia Teresinha Sfoggia, 2013, Three new species of Convolvulaceae Juss. from South America, pp. 27-34 in Phytotaxa 135 (1) on page 32, DOI: 10.11646/phytotaxa.135.1.4, http://zenodo.org/record/508614
Functional Androgen Signaling in an Explant Model of Normal Human Breast Tissue.
No full textSubmitted abstractTheresa E. Hickey, Aleksandra Ocknik, Tina Bianco-Miotto, Steve N. Birrell, Lisa M. Butler, Wayne D. Tille
Bioinorganic Chemistry of Parkinson's Disease: Affinity and Structural Features of Cu(I) Binding to the Full-Length β-Synuclein Protein
No full textAlterations in the levels of copper in brain tissue and formation of α-synuclein (αS)-copper complexes might play a key role in the amyloid aggregation of αS and the onset of Parkinson's disease (PD). Recently, we demonstrated that formation of the high-affinity Cu(I) complex with the N-terminally acetylated form of the protein αS substantially increases and stabilizes local conformations with α-helical secondary structure and restricted motility. In this work, we performed a detailed NMR-based structural characterization of the Cu(I) complexes with the full-length acetylated form of its homologue β-synuclein (βS), which is colocalized with αS in vivo and can bind copper ions. Our results show that, similarly to αS, the N-terminal region of βS constitutes the preferential binding interface for Cu(I) ions, encompassing two independent and noninteractive Cu(I) binding sites. According to these results, βS binds the metal ion with higher affinity than αS, in a coordination environment that involves the participation of Met-1, Met-5, and Met-10 residues (site 1). Compared to αS, the shift of His from position 50 to 65 in the N-terminal region of βS does not change the Cu(I) affinity features at that site (site 2). Interestingly, the formation of the high-affinity βS-Cu(I) complex at site 1 in the N-terminus promotes a short α-helix conformation that is restricted to the 1-5 segment of the AcβS sequence, which differs with the substantial increase in α-helix conformations seen for N-terminally acetylated αS upon Cu(I) complexation. Our NMR data demonstrate conclusively that the differences observed in the conformational transitions triggered by Cu(I) binding to AcαS and AcβS find a correlation at the level of their backbone dynamic properties; added to the potential biological implications of these findings, this fact opens new avenues of investigations into the bioinorganic chemistry of PD.Fil: Miotto, Marco César. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Investigaciones para el Descubrimiento de Fármacos de Rosario. Universidad Nacional de Rosario. Instituto de Investigaciones para el Descubrimiento de Fármacos de Rosario; ArgentinaFil: Pavese, Mayra D.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Investigaciones para el Descubrimiento de Fármacos de Rosario. Universidad Nacional de Rosario. Instituto de Investigaciones para el Descubrimiento de Fármacos de Rosario; ArgentinaFil: Quintanar, Liliana. Instituto Politécnico Nacional. Centro de Investigación y de Estudios Avanzados; MéxicoFil: Zweckstetter, Markus. Universität Göttingen; Alemania. Deutches Zentrum für Neurodegenerative Erkrankungen; Alemania. Max Planck Institute for Biophysical Chemistry; AlemaniaFil: Griesinger, Christian. Max Planck Institute for Biophysical Chemistry; AlemaniaFil: Fernandez, Claudio Oscar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Investigaciones para el Descubrimiento de Fármacos de Rosario. Universidad Nacional de Rosario. Instituto de Investigaciones para el Descubrimiento de Fármacos de Rosario; Argentina. Max Planck Institute for Biophysical Chemistry; Alemani
FIGURE 1. Adesmia sessilifolia. A. Branch. B. Flower. C. Calyx. D. Keel. E. Wing. F. Banner. G. Gynoecium. H. Pod. I. Seed. A–G from Z. Machado 1236 in Adesmia sessilifolia (Fabaceae), a new species from a relictual landscape in southern Brazil
No full textFIGURE 1. Adesmia sessilifolia. A. Branch. B. Flower. C. Calyx. D. Keel. E. Wing. F. Banner. G. Gynoecium. H. Pod. I. Seed. A–G from Z. Machado 1236 (ICN); H–I from Valls et al. 12864 (ICN, CEN). Drawn by J.R.V. Iganci.Published as part of Iganci, João R.V. & Miotto, Silvia T.S., 2011, Adesmia sessilifolia (Fabaceae), a new species from a relictual landscape in southern Brazil, pp. 21-24 in Phytotaxa 26 on page 22, DOI: 10.11646/phytotaxa.26.1.4, http://zenodo.org/record/489411
FIGURE 2 in Synopsis of the genus Galactia (Phaseoleae, Papilionoideae, Leguminosae) in Brazil
No full textFIGURE 2: A. Galactia martioides. B. Galactia pretiosa. C. Galactia benthamiana. D. Galactia boavista. E. Galactia striata.Published as part of Ceolin, Guilherme B. & Miotto, Sílvia T. S., 2013, Synopsis of the genus Galactia (Phaseoleae, Papilionoideae, Leguminosae) in Brazil, pp. 1-26 in Phytotaxa 134 (1) on page 14, DOI: 10.11646/phytotaxa.134.1.1, http://zenodo.org/record/508607
Expression of the androgen receptor and its association with disease outcome in breast cancer
No full textAbstractMurphy N, Bianco-Miotto T, Ricciardelli C, Ruiz AI, Segara D, McNeil CM, Crea P, Henshall SM, Birrell SN, Butler LM, Sutherland RL, Tilley WD
Corepressor effect on androgen receptor activity varies with the length of the CAG encoded polyglutamine repeat and is dependent on receptor/corepressor ratio in prostate cancer cells
No full textAbstract not availableGrant Buchanan, Eleanor F. Need, Jeffrey M. Barrett, Tina Bianco-Miotto, Vanessa C. Thompson, Lisa M. Butler, Villis R. Marshall, Wayne D. Tilley, Gerhard A. Coetze
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