1,315 research outputs found
FV Leiden pseudo-homozygotes have a more pronounced hypercoagulable state than FV Leiden homozygotes.
No full textJ Thromb Haemost. 2011 Apr;9(4):864-7. doi: 10.1111/j.1538-7836.2011.04205.x.
Factor V Leiden pseudo-homozygotes have a more pronounced hypercoagulable state
than factor V Leiden homozygotes.
Duckers C, Simioni P, Tormene D, Carraro S, Rosing J, Castoldi E.
PMID: 21251207 [PubMed - indexed for MEDLINE
Simulation of the 3-D Coulomb Explosion of the Electron-Hole Distribution at High Injection Levels in 2-D Semiconductor Detectors
No full textWe developed a novel simulation code for 3-D electron-hole transport and signal formation in semiconductor detectors. The code includes thermal diffusion and Coulomb interaction between the carriers - essential for the correct simulation of high-density ionization tracks. The present work focuses on dedicated numerical techniques to correctly simulate the explosion of high-density charge carrier clouds down to the first instants of the time evolution, when extremely high field intensities are reached due to Coulomb interaction between carriers. The case study of a p+nn+ diode irradiated by 1 keV photons on under different bias and charge injection conditions up to 107 e.h pairs is presented and discussed. This case well represents the operating conditions foreseen in the imaging detectors for the novel FEL X-ray facilities and the potential of the developed simulation code
Methylmercury interaction with lymphocyte cholinergic muscarinic receptors in developing rats
No full textCerebral cholinergic muscarinic receptors (MR) have been suggested as one of the sensitive biochemical endpoints of the central nervous system altered by developmental exposure to the widespread seafood contaminant methylmercury (MeHg). In adult rats, MeHg has been shown to alter MR binding both in the brain and lymphocytes, supporting the use of MR in blood cells as a surrogate marker of
CNS changes. The effects of MeHg have been evaluated on rat lymphocyte MR binding (using [3H]QNB as specific muscarinic ligand) in vivo (after perinatal exposure) and in vitro. For comparison, in vitro studies were also performed on human lymphocytes. Exposure to 1mg MeHg/kg/day during pregnancy and lactation (from GD7 to PND7) significantly enhanced lymphocyte MR density in both adult and young rats 21 days after delivery, with a more pronounced effect in the mothers (Bmax increase of 139%) than in the male offspring (+49%) and female offspring (+73%) as compared with their respective controls (3374, 4178, and 3774 fmol/million cells), in accordance with the higher Hg levels detected in the adult blood (11.372.2 mg/mL) than in pups (1.370.4 mg/L in both genders).
A lower MeHg dose (0.5 mg/kg/day) was without any effect on lymphocyte MRs. In in vitro studies, MeHg was an almost equipotent
inhibitor of 3H-QNB binding to rat and human lymphocyte MRs (IC50 values were 4.170.29, 5.270.51, and 5.070.9 mM for total rat
lymphocytes, rat T lymphocytes, and total human lymphocytes, respectively). Notably, the IC50 values for MeHg to lymphocyte MRs
were comparable to the Hg levels reached in blood (5–50 mM) of the PND21 rats exposed to MeHg.
The finding that the MR binding is a target for the effects of MeHg in peripheral blood cells is in accordance with our previous data in
brain [Coccini et al., 2006. Effects of developmental co-exposure to methylmercury and 2,20,4,40,5,50-hexachlorobiphenyl (PCB153) on
cholinergic muscarinic receptors in rat brain. Neurotoxicology, in press], and supports the use of this peripheral endpoint as a biomarker of MeHg-induced cerebral muscarinic alterations. The similarity of MeHg IC50 binding data between human and rat in peripheral tissues suggests the possible application of such biomarker to humans exposed to environmental chemical
Natural products with taxol-like anti-tumour activity : synthetic approaches to eleutherobin and dictyostatin
No full textEleutherobin and dictyostatin are antimitotic compounds which exert their cytotoxic activity by a taxol-like mode of action, i.e., hypernucleating tubulin assembly and interfering with the dynamic instability of the cytoskeleton during mitosis. A formal total synthesis
of eleutherobin was accomplished by accessing a key intermediate reported by
Danishefsky and coworkers in their 1998 synthesis of the natural product. The key step of our strategy, used for obtaining the [8.4.0] fused bicyclic ring system, is a ring-closing metathesis (RCM) reaction of a densely functionalized diene under forcing conditions, using Grubbs’ second-generation catalyst. Synthetic approaches to dictyostatin are also described,
and in particular the preparation of the C15–C23 fragment of the macrolide, containing 5 of its 11 stereocenters
Hardware, Firmware and Software Architecture of the DAQ for High-Resolution Position-Sensing Silicon Drift Detectors With Multiple-Pulse Processing Capability
No full text2-D response mapping of Multi-Linear Silicon Drift Detectors
No full textMulti-linear silicon drift detectors (MLSDDs) are good candidates to fulfill simultaneous requirements for 2-D position-sensing and spectroscopy applications. The optimization of their design and performance as 2-D imagers requires a detailed study of timing properties of the charge cloud in the MLSDD architecture. In particular it is important to experimentally determine the dependence of the measured amplitude and time-of-arrival on the photon position of interaction so as to derive the 2D detector response. In this paper we will present a detailed experimental characterization aimed at measuring the detector amplitude response and its timing response. The dependence of charge cloud drift time on precise position of interaction has been measured as a function of detector biasing conditions
A 3-D Simulation Tool for Design and Data Correction of X-Ray Scatter Imaging Experiments
No full textVirtualized eNB latency limits
No full textIn flexible functional split, functions of a virtualized evolved NodeB (eNB) can be disaggregated in distributed computational resources. One of the main constraints for their placement is the latency experienced by the communication between the Virtual Machines (VM) hosting the functions. This paper evaluates experimentally the latency limits for different functional splits providing insights on flexible functional split implementation
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