594 research outputs found
Laslett P., Eversley D. E. C., Armstrong W. A. — An introduction to English historical demography
No full textLaslett P., Eversley D. E. C., Armstrong W. A. — An introduction to English historical demography. In: Population, 21ᵉ année, n°3, 1966. p. 602
Laslett P., Eversley D. E. C., Armstrong W. A. — An introduction to English historical demography
No full textLaslett P., Eversley D. E. C., Armstrong W. A. — An introduction to English historical demography. In: Population, 21ᵉ année, n°3, 1966. p. 602
ARAGORN, a program to detect tRNA genes and tmRNA genes in nucleotide sequences
No full textA computer program, ARAGORN, identifies tRNA and tmRNA genes. The program employs heuristic algorithms to predict tRNA secondary structure, based on homology with recognized tRNA consensus sequences and ability to form a base-paired cloverleaf. tmRNA genes are identified using a modified version of the BRUCE program. ARAGORN achieves a detection sensitivity of 99% from a set of 1290 eubacterial, eukaryotic and archaeal tRNA genes and detects all complete tmRNA sequences in the tmRNA database, improving on the performance of the BRUCE program. Recently discovered tmRNA genes in the chloroplasts of two species from the ‘green’ algae lineage are detected. The output of the program reports the proposed tRNA secondary structure and, for tmRNA genes, the secondary structure of the tRNA domain, the tmRNA gene sequence, the tag peptide and a list of organisms with matching tmRNA peptide tags
ARWEN: a program to detect tRNA genes in metazoan mitochondrial nucleotide sequences
No full textMotivation: Mitochondrial genomes encode their own transfer RNAs (tRNAs). These are often degenerate in sequence and structure compared to tRNAs in their bacterial ancestors. This is one of the reasons why current tRNA gene predictor programs perform poorly identifying mitochondrial tRNA genes. As a consequence there is a need for a new program with the specific aim of predicting these tRNAs.
Results: In this study, we present the software ARWEN that identifies tRNA genes in metazoan mitochondrial nucleotide sequences. ARWEN detects close to 100% of previously annotated genes
Patient education--the forgotten link in managing osteoporosis
No full textCopyright © 2004 Royal Australian College of General Practitioners Copyright to Australian Family Physician. Reproduced with permission. Permission to reproduce must be sought from the publisher, The Royal Australian College of General Practitioners.BACKGROUND: Osteoporosis and bone fractures are common, yet osteoporosis is under diagnosed in Australian settings. Osteoporosis can now be reliably diagnosed, and safely and effectively treated, but patient education strategies are under utilised. OBJECTIVE: This article discusses the role of education in osteoporosis risk reduction and management. DISCUSSION: Osteoporosis education initiatives such as the Osteoporosis Prevention and Self Management Course can increase knowledge, self efficacy and health related behaviours such as calcium intake and exercise over the short to medium term.Laura L. Laslett, Julian D. O'Neil and Joan Lync
Corrigendum to The Australian Drug Harms Ranking Study
No full textThe author regrets an error on page 6, paragraph 1, line 6: ‘In Australia, the cost of the harms caused by the drinking of others was estimated to be approximately AUD 13 billion in tangible costs and a further AUD $6.8 billion in hospital, child protection and intangibles in 2010 (Laslett et al., 2010)’.No Full Tex
Osteoporosis education improves osteoporosis knowledge and dietary calcium: comparison of a 4 week and a one-session education course
No full textBackgroundEducation is ideal for osteoporosis because many risk factors are modifiable. However, the efficacy of shortened education courses compared to a standard 4 week course for improving osteoporosis knowledge and healthy behaviours is not known. This study aimed to assess whether education changed knowledge and healthy behaviours over 3 months of follow-up; and whether changes in these outcomes were different between participants receiving the different education courses.MethodsAdults aged ≥ 50 years presenting to Emergency with mild to moderate trauma fractures received either the Osteoporosis Prevention and Self-Management Course (OPSMC) (4 × 2.5 h) (n = 75) or a one-session course (1 × 2.5 h) (n = 71) in a non-randomised prospective study with single-blinded allocation. Participants completed questionnaires measuring osteoporosis knowledge, dietary calcium, physical activity, calcium and exercise self-efficacy, and osteoporosis medications at baseline and 3 months. Data were analysed using mixed models and GEE regression models.ResultsOsteoporosis knowledge and calcium from food (% of RDI) increased from baseline to 3 months in both groups (P ConclusionsOsteoporosis education (either the OPSMC or the one-session course) improved osteoporosis knowledge and calcium intake after 3 months. Participants attending the OPSMC maintained medication compliance. We were unable to determine other differences between the courses. This study confirms the value of osteoporosis education for improving osteoporosis knowledge.Laura L. Laslett, Joan Lynch, Thomas R. Sullivan and Julian D. McNei
Pyramidal Democracy
No full textWe consider a decentralized, multilayered representative democracy, where citizens participate in deliberative policy formation after self-organizing into a pyramidal hierarchy of small groups. Each group elects a delegate, who expresses the deliberative consensus of that group at the next tier of the pyramid. The pyramid thus acts as a communications network which efficiently aggregates useful information and policy ideas. It is also a powerful meritocratic device, which channels legislative responsibility towards the most committed and competent citizens. This yields a practical implementation of deliberative democracy in a large polity.deliberative democracy
Predictors of shoulder pain and shoulder disability after one year in diabetic outpatients
No full text© The Author 2008. Published by Oxford University Press on behalf of the British Society for Rheumatology.Objective. To investigate factors associated with changes in shoulder pain and disability in diabetic outpatients over 1 yr. Methods. Cross-sectional study with 12-month follow-up in diabetic outpatients (n = 179) using the shoulder pain and disability index (SPADI) and SF-36 version 2. Results. Patients with diabetes and shoulder pain or disability are more likely to be older and female. After 12 months of follow-up, one-quarter of participants without pre-existing symptoms at baseline developed clinically significant pain (28%) or disability (25%). Of the patients with pre-existing shoulder pain or disability, half reported clinically significant worsening (10 percentage points) in shoulder pain (58%) or disability (45%) over 12 months. Few patients demonstrated clinically significant improvement in pain (11%) or disability scores (19%). The remaining one-third of the patients reported no change in symptoms (30% pain; 35% disability). Increasing intensity of pain scores between baseline and 12 months was associated with older age, higher HbA1c and less pain at baseline. Increasing disability score between baseline and 12 months was associated with having had eye laser surgery, greater pain at baseline and less disability at baseline. Conclusion. Shoulder pain and disability are common, and persistent in adults with diabetes. Having higher HbA1c levels or having had treatment for retinopathy was associated with worsening shoulder pain and disability, confirming that glycaemic control and diabetic complications are associated with worsening shoulder pain or disability over 12 months of observation.L. L. Laslett, S. P. Burnet, C. L. Redmond and J. D. McNei
Mortality crisis and household structure: an analysis of parish registers and the Compton census, Broughton, Lancashire, 1667-1676
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