150 research outputs found
Update on the controversies of tocolytic therapy for the prevention of preterm birth - letter to the editor
No full textD. N. M. Papatsonis, B. Carbonne, G. A. Dekker, J. F. King And V. J. Flenad
Response to 'The drugs we deserve'
No full textDNM Papatsonis, VJ. Flenady, GA. Dekker, B. Carbonne, JF Kin
Reply to Dr Lamont - letter to the editor
No full textThe definitive version is available at www.blackwell-synergy.comJames F. King, Vicki Flenady, Dimitri Papatsonis, Gus Dekker, Bruno Carbonn
Severe hypotension and fetal death due to tocolysis with nifedipine - Correspondence
No full textDimitri N. M. Papatsonis, Bruno Carbonne, Gustaaf A. Dekker, Vicki Flenady & James F. Kin
Use of intra-uterine pressure catheter (IUPC) versus external tocodynamometry (TOCO) during labour for reducing adverse outcomes
No full textJannet JH Bakker, Petra F Janssen, Ben Willem J Mol, Dimitri Papatsonis, Jan MM van Lith, Joris AM van der Pos
Effect of 17-alpha hydroxyprogesterone caproate on cervical length in twin pregnancies
No full textAbstract not availableA. C. Lim, E. Schuit, D. Papatsonis, J. van Eyck, M. M. Porath, C. M. van Oirschot, P. Hummel, T. H. M. Hasaart, G. Kleiverda, I. M. de Graaf, A. A. van Ginkel, B. W. J. Mol and H. W. Bruins
Can neonatal sepsis be predicted in late preterm premature rupture of membranes? Development of a prediction model
No full textAbstract not availableDavid P. van der Ham, Sander van Kuijk, Brent C. Opmeer, Christine Willekes, Johannes J. van Beek, Antonius L.M. Mulder, Aren J. van Loon, Martiët Groenewout, Gerald D. Mantel, Kitty W.M. Bloemenkamp, Martina Porath, Anneke Kwee, Bettina M.C. Akerboom, Dimitri N.M. Papatsonis, Godfried C.H. Metz, Jan G. Nijhuis, Ben W.J. Mol, The PPROMEXIL trial grou
Calcium channel blockers for inhibiting preterm labour; a systematic review of the evidence and a protocol for administration of nifedipine
No full textThe definitive version is available at www.blackwell-synergy.comObjective: To assess the effects on maternal, fetal and neonatal outcomes of nifedipine (and other calcium channel blockers) administered as a tocolytic agent to women in preterm labour. Methods: Standard methods of the Cochrane Collaboration and its Pregnancy and Childbirth Review Group were used. All published and unpublished randomised trials in which calcium channel blockers were used for tocolysis for women in preterm labour between 20 and 36 weeks’ gestation, were considered. Main results: The systematic review includes 12 randomised controlled trials with a total of 1029 participating women. No trials were identified in which calcium channel blockers were compared with a placebo or no alternative tocolytic treatment. Calcium channel blockers appear to be more effective than betamimetic agents in prolonging pregnancy for 7 days or longer, are much less likely to cause maternal side-effects and are associated with reduced neonatal morbidity. Conclusion: Calcium channel blockers (especially nifedipine) can be considered safer and more effective tocolytic agents than betamimetics.James F. King, Vicki Flenady, Dimitri Papatsonis, Gustaaf Dekker, Bruno Carbonn
Hemodynamic and metabolic effects after nifedipine and ritodrine tocolysis
No full textObjectives: The purpose of this study is to compare the hemodynamic and metabolic changes after ritodrine and nifedipine tocolysis. Methods: For an open randomized study, patients with preterm labor (N=185) were allocated to groups to receive ritodrine intravenously (N=90) or nifedipine orally (N=95). Results: The mean diastolic blood pressure was significantly lower in the ritodrine group 24 h (65±12 vs. 70±8, P=0.001) and 48 h (65±12 vs. 71±8, P=0.004) after starting tocolysis compared with the nifedipine group. Mean maternal heart rate was significantly higher in the ritodrine group 24 h (105±17 vs. 86±13, P<0.0001) and 48 h (100±21 vs. 85±12, P<0.0001) after starting tocolysis compared with the nifedipine group. Mean fasting glucose levels were higher (6.68±2.53 vs. 4.93±1.23, P=0.0016), while mean potassium levels were lower (3.52±0.84 vs. 3.81±0.45, P=0.04) in the ritodrine group 48 h after starting tocolysis compared with the nifedipine group. Conclusions: Use of nifedipine for preterm labor is associated with a lower incidence of adverse hemodynamic and metabolic changes compared with ritodrine after 24 and 48 h of tocolysis. In our opinion nifedipine is the preferred drug of choice for the treatment of preterm labor.D. N. M. Papatsonis, H. P. van Geijn, O. P. Bleker, H. J. Adèr and G. A. Dekke
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