797 research outputs found
Parameterization of e and gamma initiated showers in the NOMAD lead-glass calorimeter
No full textA description of the response of the NOMAD electromagnetic calorimeter to electrons and photons is discussed. In
particular, the dependence of the two-dimensional shower shape on the angle and energy of the incident particle is
parametrized by analytical functions. Some applications to the neutrino event reconstruction are also reported
A high stability light emitting diode system for monitoring lead-glass electromagnetic calorimeters
No full textA high stability system based on blue light emitting diodes (LED) and current pulse generator has been designed, built and tested for the calibration and monitoring of the NOMAD lead-glass calorimeter
A study of the transverse fluctuations of hadronic showers in the NOMAD electromagnetic calorimeter
No full textThe transverse shower shape of the energy deposition of hadrons in the NOMAD lead-glass calorimeter has been studied by exposing a prototype of this calorimeter to pion test beam of various momenta and incident angles
Application of FSE approach for structural fire safety assessment of car and motor scooter parks
No full textIn the international research field, the application of the FSE approach to study car parks fire behaviour is a well-investigated topic, unlike when the park is intended for motorcycles. Thus, the aim of this work is to investigate several fire scenarios correlated to the two different intended uses. Different fire curves were obtained thanks to thermo-fluid-dynamic zone models knowing Heat Release Rate (HRR) curves from the literature. Results showed that a motorcycle fire can become significant for exodus reason, while the car fire must be considered for structural fire resistance purpose. Several advanced thermo-mechanical analyses were carried out on substructures selected according to FSE criteria, both using natural and nominal fire curves. The results have underlined the importance of the FSE to reduce the structural fire demand
Structural fire safety assessment of car and motor scooter RC parks using the FSE approach
No full textCHARACTERISTICS AND PERFORMANCE OF AN ELECTROMAGNETIC SHOWER SAMPLING CALORIMETER WITH WAVELENGTH SHIFTING FIBER READOUT
No full textWe have studied the properties of electromagnetic shower counters made of scintillator and lead tiles of different thickness. Light collection is achieved by wavelength shifting fibres sparse in the body of the calorimeter. The counters were tested in a beam of electrons, pions and muons with energies between 2 and 8 GeV. We report here the final results of the test. The energy resolution is in good agreement with what is expected from the sampling fraction, i.e. sigma/E = 0.07/root E, the non uniformity of the response is less than 1% at the centre of a counter and 7 in the boundaries between modules, and the pi/e contamination is at the level of a few 10(-3). Performance of the calorimeter with readout systems able to operate in magnetic field is also reported
Superluminal velocity through near-maximal neutrino oscillations or by being off shell
No full textRecently it was suggested that the observation of superluminal neutrinos by the OPERA collaboration may be due to group velocity effects resulting from close-to-maximal oscillation between neutrino mass eigenstates, in analogy to known effects in optics. We show that superluminal propagation does occur through this effect for a series of very narrow energy ranges, but this phenomenon cannot explain the OPERA measurement. Superluminal propagation can also occur if one of the neutrino masses is extremely small. However the effect only has appreciable amplitude at energies of order this mass and thus has negligible overlap with the multi-GeV scale of the experiment
Mapping the minimum domain of the fibronectin binding site on transglutaminase 2 (TG2) and its importance in mediating signaling, adhesion, and migration in TG2-expressing cells
No full textThe interaction between the enzyme transglutaminase 2 (TG2) and fibronectin (FN) is involved in the cell-matrix interactions that regulate cell signaling, adhesion, and migration and play central roles in pathologic conditions, particularly fibrosis and cancer. A precise definition of the exact interaction domains on both proteins could provide a tool to design novel molecules with potential therapeutic applications. Although specific residues involved in the interaction within TG2 have been analyzed, little is known regarding the TG2 binding site on FN. This site has been mapped to a large internal 45-kDa protein fragment coincident with the gelatin binding domain (GBD). With the goal of defining the minimal FN interacting domain for TG2, we produced several expression constructs encoding different portions or modules of the GBD and tested their binding and functional properties. The results demonstrate that the I8 module is necessary and sufficient for TG2-binding in vitro, but does not have functional effects on TG2-expressing cells. Modules I7 and I9 increase the strength of the binding and are required for cell adhesion. A 15-kDa fragment encompassing modules I7-9 behaves as the whole 45-kDa GBD and mediates signaling, adhesion, spreading, and migration of TG2+ cells. This study provides new insights into the mechanism for TG2 binding to FN.-Soluri, M. F., Boccafoschi, F., Cotella, D., Moro, L., Forestieri, G., Autiero, I., Cavallo, L., Oliva, R., Griffin, M., Wang, Z., Santoro, C., Sblattero, D. Mapping the minimum domain of the fibronectin binding site on transglutaminase 2 (TG2) and its importance in mediating signaling, adhesion, and migration in TG2-expressing cells
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