1,354,869 research outputs found
ARISTOTELE, La Politica, Libro III, Introduzione, traduzione e commento a c. di P. Accattino, testo greco, apparati critici e note testuali a c. di M. Curnis
No full textBlockade of αvβ6 and αvβ8 integrins with a chromogranin A-derived peptide inhibits TGFβ activation in tumors and suppresses tumor growth
No full textThese files contain the raw images and dataset used to generate Figures 1A, 5 (panels B, C, and G), 6 (panels A, D, E and F), and S3A of the article titled “Blockade of αvβ6 and αvβ8 integrins with a chromogranin A-derived peptide inhibits TGFβ activation in tumors and suppresses tumor growth” by A.M. Gasparri, A. Pocaterra, B. Colombo, G. Taiè, C. Gnasso, A. Gori, F. Pozzi, A. Smith, F. Magni, A. Ugolini, M. Doglio, M.C. Bonini, A. Mondino, A. Corti, and C. Curnis, published in J Exp Clin Cancer Res 44, 88 (2025). https://doi.org/10.1186/s13046-025-03352-4
The research leading to these findings was funded by Associazione Italiana per la Ricerca sul Cancro (AIRC) under IG 2019 – ID. 23470 project – P.I. Angelo Corti; Fondazione AIRC 5 per Mille 2019 program (ID. 22737), P.I. MC Bonini, Group Leader A. Corti and A. Mondino; collectively supported by the national funding organizations under the framework of the ERA-NET TRANSCAN-3 initiative (ReachGlio project, ID: TRANSCAN2022-784-017 – Italian Ministry of Health ID: ERP-2022-23683648 to F. Curnis); and National Recovery and Resilience Plan (NRRP), M6/C2_CALL 2023 (project: POC-2023-12377318 to F. Curnis) funded by the European Union – NextGenerationEU
Neuropilin-1 and Integrins as Receptors for Chromogranin A-Derived Peptides
No full textHuman chromogranin A (CgA), a 439 residue-long member of the “granin” secretory protein family, is the precursor of several peptides and polypeptides involved in the regulation of the innate immunity, cardiovascular system, metabolism, angiogenesis, tissue repair, and tumor growth. Despite the many biological activities observed in experimental and preclinical models for CgA and its most investigated fragments (vasostatin-I and catestatin), limited information is available on the receptor mechanisms underlying these effects. The interaction of vasostatin-1 with membrane phospholipids and the binding of catestatin to nicotinic and b2-adrenergic receptors have been proposed as important mechanisms for some of their effects on the cardiovascular and sympathoadrenal systems. Recent studies have shown that neuropilin-1 and certain integrins may also work as high-affinity receptors for CgA, vasostatin-1 and other fragments. In this case, we review the results of these studies and discuss the structural requirements for the interactions of CgA-related peptides with neuropilin-1 and integrins, their biological effects, their mechanisms, and the potential exploitation of compounds that target these ligand-receptor systems for cancer diagnosis and therapy. The results obtained so far suggest that integrins (particularly the integrin avb6) and neuropilin-1 are important receptors that mediate relevant pathophysiological functions of CgA and CgA fragments in angiogenesis, wound healing, and tumor growth, and that these interactions may represent important targets for cancer imaging and therapy
Boosting Interleukin-12 Antitumor Activity and Synergism with Immunotherapy by Targeted Delivery with isoDGR-Tagged Nanogold
No full textRaw data and original images for the article entitled "Boosting Interleukin-12 Antitumor Activity and Synergism with Immunotherapy by Targeted Delivery with isoDGR-Tagged Nanogold" by Gasparri AM, Sacchi A, Basso V, Cortesi F, Freschi M, Rrapaj E, Bellone M, Casorati G, Dellabona P, Mondino A, Corti A, Curnis F.
Small. 2019 Nov;15(45):e1903462. doi: 10.1002/smll.201903462
Transseptal catheterization of the native septum for atrial fibrillation ablation in presence of septal occluder device: a novel approach with real-time 3D transesophageal echocardiographic guidance
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Clinical approach to cardiac pauses in congenital central hypoventilation syndrome
No full textCongenital central hypoventilation syndrome (CCHS) patients may have heart rhythm disorders related to autonomic nervous system dysfunction such as, sinus bradycardia and transient asystole with potentially dramatic syncopal events. The diagnosis of these cardiac alterations may be challenging with conventional periodical Holter monitoring. The case shows how continuous heart rhythm monitoring provided by the implantable cardiac monitor (ICM) may play a crucial role for their early diagnosis and the choice of the appropriate therapeutic intervention
The perks of narcissism: Behaving like a star speeds up career advancement to the CEO position
No full textIt is widely acknowledged that narcissism is a peculiar characteristic of leaders, such as CEOs. However, the role of narcissism in CEO emergence and appointment has not been studied yet. We overcome this gap by studying whether having a highly narcissistic personality allows individuals to become CEOs sooner. We posit that these individuals have quicker career development, climbing the hierarchical chain faster. We also hypothesize that this relation may be moderated by the firm's characteristics, comparing family and nonfamily firms. Family firms are the most widespread organizational form of firms around the world, and their peculiarities might affect the appointment of narcissistic CEOs. Estimates on a sample of 172 individuals partially confirm the hypotheses. Highly narcissistic individuals become CEOs quicker, regardless of whether the firm is a family business or not. Narcissistic individuals thus benefit from their personality when aiming at becoming CEOs faster in their career advancement
Cost-effectiveness of radiofrequency catheter ablation of supraven-tricular tachycardia in a tax-funded health care system
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