4,284 research outputs found

    Employment conditions in the scottish social care voluntary sector : impact of public funding constraints in the context of economic recession

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    This report uses data to assess the impact of public funding constraints on employment conditions in the Scottish social care voluntary sector, in the context of the recent economic recessionand future public expenditure cuts

    Managing complexity in a distributed digital library

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    As the capabilities of distributed digital libraries increase, managing organizational and software complexity becomes a key issue. How can collections and indexes be updated without impacting queries currently in progress? How can the system handle several user-interface clients for the same collections? Computer science professors and lectors from the University of Waikato have developed a software structure that successfully manages this complexity in the New Zealand Digital Library. This digital library has been a success in managing organizational and software complexity. The researchers' primary goal has been to minimize the effort required to keep the system operational and yet continue to expand its offerings

    Progesterone activates multiple innate immune pathways in Chlamydia trachomatis-infected endocervical cells

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    Problem: Susceptibility to Chlamydia trachomatis infection is increased by oral contraceptives and modulated by sex hormones. We therefore sought to determine the effects of female sex hormones on the innate immune response to C. trachomatis infection. Method of study: ECC-1 endometrial cells, pre-treated with oestradiol or progesterone, were infected with C. trachomatis and the host transcriptome analysed by Illumina Sentrix HumanRef-8 microarray. Primary endocervical epithelial cells, prepared at either the proliferative or secretory phase of the menstrual cycle, were infected with C. trachomatis and cytokine gene expression determined by quantitative RT-PCR analysis. Results: Chlamydia trachomatis yield from progesterone-primed ECC-1 cells was significantly reduced compared with oestradiol-treated cells. Genes upregulated in progesterone-treated and Chlamydia-infected cells only included multiple CC and CXC chemokines, IL-17C, IL-29, IL-32, TNF-α, DEFB4B, LCN2, S100A7-9, ITGAM, NOD2, JAK1, IL-6ST, type I and II interferon receptors, numerous interferon-stimulated genes and STAT6. CXCL10, CXCL11, CX3CL1 and IL-17C, which were also upregulated in infected secretory-stage primary cells, and there was a trend towards higher levels of immune mediators in infected secretory-phase compared with proliferative-phase cells. Conclusion: Progesterone treatment primes multiple innate immune pathways in hormone-responsive epithelial cells that could potentially increase resistance to chlamydial infection.Charles Wan, Joanna L. Latter, Ashkan Amirshahi, Ian Symonds, Jane Finnie, Nikola Bowden, Rodney J. Scott, Kelly A. Cunningham, Peter Timms, Kenneth W. Beagle

    Landslide, coseismic liquefaction susceptibility, and coseismic soil amplification class maps, Benton, Marion, Morrow, and Washington Counties, Oregon

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    by Robert W. Hairston-Porter, Ian P. Madin, William J. Burns, and Christina A. Appleby.This archived document is maintained by the State Library of Oregon as part of the Oregon Documents Depository Program. It is for informational purposes and may not be suitable for legal purposes.Includes bibliographical references (pages 48-49).Mode of access: Internet from the Oregon Government Publications Collection.Text in English

    James Bond: international man of gastronomy

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    This article is concerned with the representation of food and drink in Ian Fleming’s James Bond novels. In particular, it examines how the author uses Bond’s culinary knowledge and habits of consumption as an important constituent of his hero’s character. Similarly, the food choices of other characters, notably villains, are shown to be linked, by Fleming, to core aspects of their identity − principally their ethnicity. Bond’s impulse to observe and classify, very much in evidence in the novels’ food sequences, is examined in terms of the texts’ construction of Bond as a skilled identifier of signs

    Transforming Power Relationships: Leadership, Risk, and Hope. IHS Political Science Series No. 135, May 2013

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    Chronic communal conflicts resemble the prisoner’s dilemma. Both communities prefer peace to war. But neither trusts the other, viewing the other’s gain as its own loss, so potentially shared interests often go unrealized. Achieving positive-sum outcomes from apparently zero-sum struggles requires a kind of riskembracing leadership. To succeed leaders must: a) see power relations as potentially positive-sum; b) strengthen negotiating adversaries instead of weakening them; and c) demonstrate hope for a positive future and take great personal risks to achieve it. Such leadership is exemplified by Nelson Mandela and F.W. de Klerk in the South African democratic transition. To illuminate the strategic dilemmas Mandela and de Klerk faced, we examine the work of Robert Axelrod, Thomas Schelling, and Josep Colomer, who highlight important dimensions of the problem but underplay the role of risk-embracing leadership. Finally we discuss leadership successes and failures in the Northern Ireland settlement and the Israeli-Palestinian conflict

    2021 Oregon seismic hazard database: purpose and methods

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    Report. 2021 Oregon seismic hazard database : purpose and methods -- Plate 1. Perceived shaking and damage potential, probabilistic earthquake model -- Plate 2. Perceived shaking and damage potential, Cascadia subduction earthquake model -- Plate 3. Probability of damaging shaking.by Ian P. Madin, Jon J. Francyzk, John M. Bauer, and Carlie J.M. Azzopardi.Title from PDF cover (viewed on June 24, 2021).This archived document is maintained by the State Library of Oregon as part of the Oregon Documents Depository Program. It is for informational purposes and may not be suitable for legal purposes.Includes bibliographical references (pages 44-47).Mode of access: Internet from the Oregon Government Publications Collection.Text in English

    Interview with Ian Dawson

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    Artist Boss presents a series of illustrated interviews with Anthony Caro's (1924-2013) studio assistants and critical essays that explore the role of artists' assistants to raise questions concerning the status of production, originality, authenticity, and authorship within the tradition of twentieth-century British sculpture. From varied backgrounds, the assistants' responses illustrate the different ways in which the evolution of sculptural language has been negotiated. They provide immediate access to artists' thought processes and an insight into the complexity of changing roles. Collectively they reflect and offer a range of perspectives on the frequently contentious and widely discussed role of the artist s assistant and modes of sculptural production. Contributors include: Anthony Caro, Guy Martin, James Wolfe (US), Willard Boepple (US), Andre Fauteux (Canada), John Gibbons, Jon Isherwood (US), Shaun Cassidy (US), Ian Dawson, Beth Cullen-Kerridge, Gavin Morris, Tim Peacock, Hywel Livingstone, Jonathan Gilderleeves, William Fausset, Patrick Cunningham, Olivia Bax, Neil Ayling & John Wallbank. Forewords by Tim Marlow and Karen Wilkin Essays by Jenny Dunseath and Mark Wilsher, Dr Michael Petry, Prof K P Cross and Sam Cornis

    Cold war theology: a controversial religious image of King James VI & I in England and on the Continent in 1603

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    A former student of James Cameron’s, Ian Hazlett contributes a paper very much in the spirit of his teacher. It considers the afterlife of the King’s (or Negative) Confession, commissioned by James VI of Scotland in 1581 as a clear statement of his Calvinist credentials. By the time he gained the crown of England in 1603 however, his evolving religious views meant it had become a document he sought to distance himself from. Both Protestant and Catholic propagandists and publishers, keen to give a particular picture of the theological sympathies of the new English king, subsequently produced a surprisingly varied selection of versions of the Confession. These sources and what they can tell us about the theology and politics of the day are considered here for the first time in a scholarly study.Publisher PD

    Effect of water temperature and flow rate on the transmission of microsporidial gill disease caused by Loma salmonae in rainbow trout Oncorhynchus mykiss

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    Two studies were designed to quantify the effect of water temperature and flow rate on the transmission potential of the important salmonid gill pathogen, Loma salmonae. Using survival analysis, increased water temperature and low flow rates were determined as risk factors for the transmission of microsporidial gill disease caused by L. salmonae in rainbow trout Oncorhynchus mykiss. Fish were experimentally infected with L. salmonae via a cohabitation exposure model and monitored for the development of branchial xenomas. On any given day, fish held at 11degreesC and 15degreesC had a hazard ratio equal to 0.80 and 0.68, respectively, for the development of branchial xenomas compared with fish held at 19degreesC. From the flow rate trial, fish housed in a low flow tank (0.83 L/min) had an increased chance of developing branchial xenomas when compared to fish in tanks at normal (1.67 L/min) and high (2.5 L/min) flow rates with hazard ratios reported as 0.69.PT: J; CR: BARKER DE, 2000, AQUACULTURE, V187, P261 BEAMAN HJ, 1998, THESIS U PRINCE EDWA BEAMAN HJ, 1999, J AQUAT ANIM HEALTH, V11, P237 BEBAKWILLIAMS J, 2002, J FISH DIS, V25, P715 BECKER JA, 2002, J FISH DIS, V25, P673 BODENSTEINER LR, 2000, J AQUAT ANIM HEALTH, V12, P209 CLEVES MA, 2002, INTRO SURVIVAL ANAL GEORGIADIS MP, 2001, PREV VET MED, V48, P287 GUTIERREZ RG, 2002, STATA J, V1, P22 HEDRICK RP, 1998, J AQUAT ANIM HEALTH, V10, P107 KENT ML, 1995, CAN VET J, V36, P98 KLEINBAUM DG, 1986, SURVIVAL ANAL SELF L, P4 MAGOR BG, 1987, CAN J ZOOL, V65, P751 PENNELL W, 1996, PRINCIPLES SALMONID RAMSAY JM, 2001, J FISH DIS, V24, P453 RENO PW, 1998, J AQUAT ANIM HEALTH, V10, P160 ROSS RM, 1995, AQUACULT ENG, V14, P29 SEDGWICK SD, 1990, TROUT FARMING HDB SHAW RW, 1998, DIS AQUAT ORGAN, V33, P151 SHAW RW, 2000, DIS AQUAT ORGAN, V43, P49 SPEARE DJ, 1998, CONTEMP TOP LAB ANIM, V37, P55 SPEARE DJ, 1998, J FISH DIS, V21, P345 SPEARE DJ, 1998, J FISH DIS, V21, P93 SPEARE DJ, 1999, J FISH DIS, V22, P277; NR: 24; TC: 6; J9: FISH PATHOL; PG: 8; GA: 815FNSource type: Electronic(1
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