300 research outputs found
Second Cancer Onset in Myeloproliferative Neoplasms: What, When, Why?
Get PDFThe risk of developing a solid cancer is a major issue arising in the disease course of a myeloproliferative neoplasm (MPN). Although the connection between the two diseases has been widely described, the backstage of this complex scenario has still to be explored. Several cellular and molecular mechanisms have been suggested to link the two tumors. Sometimes the MPN is considered to trigger a second cancer but at other times both diseases seem to depend on the same source. Increasing knowledge in recent years has revealed emerging pathways, supporting older, more consolidated theories, but there are still many unresolved issues. Our work aims to present the biological face of the complex clinical scenario in MPN patients developing a second cancer, focusing on the main cellular and molecular pathways linking the two diseases
CAPRI versus AGLINK-COSIMO: Two partial equilibrium models - Two baseline approaches
Get PDFThe agricultural modelling world has generated several models aiming at the analysis of the response of the sector to certain changes in exogenous mainly policy variables. Among those, the CAPRI modelling system developed by a consortium centred on the University of Bonn and the AGLINK-COSIMO model, a joint product of the OECD and the FAO, are well known and accepted as comprehensive tools. This analysis focuses on a qualitative comparison of both models and particularly on the process of setting up the baseline. The baseline is a medium-term projection of agricultural markets reflecting current policies and those already decided upon. This projection in turn serves as the base for comparisons when analyzing scenarios. It is shown that CAPRI uses generic and automatic procedures whenever possible for conducting the database and the baseline, while AGLINK-COSIMO puts more emphasis on expert knowledge in this process. Both approaches are shown to have certain advantages while the conclusion that a combination of them would potentially improve both models will be drawn from this analysis.CAPRI, AGLINK-COSIMO, Baseline process, Agricultural and Food Policy,
Factors Affecting the Quality of Bacterial Genomes Assemblies by Canu after Nanopore Sequencing
Get PDFLong-read sequencing (LRS), like Oxford Nanopore Technologies, is usually associated with higher error rates compared to previous generations. Factors affecting the assembly quality are the integrity of DNA, the flowcell efficiency, and, not least all, the raw data processing. Among LRS-intended de novo assemblers, Canu is highly flexible, with its dozens of adjustable parameters. Different Canu parameters were compared for assembling reads of Salmonellaenterica ser. Bovismorbificans (genome size of 4.8 Mbp) from three runs on MinION (N50 651, 805, and 5573). Two of them, with low quality and highly fragmented DNA, were not usable alone for assembly, while they were successfully assembled when combining the reads from all experiments. The best results were obtained by modifying Canu parameters related to the error correction, such as corErrorRate (exclusion of overlaps above a set error rate, set up at 0.40), corMhapSensitivity (the coarse sensitivity level, set to “high”), corMinCoverage (set to 0 to correct all reads, regardless the overlaps length), and corOutCoverage (corrects the longest reads up to the imposed coverage, set to 100). This setting produced two contigs corresponding to the complete sequences of the chromosome and a plasmid. The overall results highlight the importance of a tailored bioinformatic analysis
Exploring the Potential of Eltrombopag: Room for More?
Get PDFSince its introduction in clinical practice, eltrombopag (ELT) has demonstrated efficacy in heterogeneous clinical contexts, encompassing both benign and malignant diseases, thus leading researchers to make a more in-depth study of its mechanism of action. As a result, a growing body of evidence demonstrates that ELT displays many effects ranging from native thrombopoietin agonism to immunomodulation, anti-inflammatory, and metabolic properties. These features collectively explain ELT effectiveness in a broad spectrum of indications; moreover, they suggest that ELT could be effective in different, challenging clinical scenarios. We reviewed the extended ELT mechanism of action in various diseases, with the aim of further exploring its full potential and hypothesize new, fascinating indications
Clonal hematopoiesis in clinical practice: walking a tightrope
No full textThe understanding of clonal hematopoiesis (CH) and its features is rapidly evolving in step with the spread of sequencing techniques. Indeed, CH detection is now an emerging aspect in clinical practice. The awareness of CH intersects with consolidated diagnostic paths, thus exposing 'grey zone' circumstances under the magnifying lens of clinicians. The interpretation of genomic data poses, in some cases, a true clinical challenge, sometimes further complicating the route to diagnosis. The line separating different entities is thin. The present work aims to review some of these challenging situations to help clinicians keep their balance along this tightrope
Prime osservazioni sul rapporto tra il reato di “Diffusione illecita di immagini o video sessualmente espliciti” e le libertà di corrispondenza e di manifestazione del pensiero
Get PDFL’articolo concerne il rapporto tra il reato di “Diffusione illecita di immagini o video sessualmente espliciti” (art. 612-ter c.p.) e le libertà costituzionali di corrispondenza (art. 15 Cost.) e di manifestazione del pensiero (art. 21 Cost.). Nello specifico, l’Autore si chiede se il reato di cui all’art. 612-ter incida sulle libertà di cui all’art. 15 e all’art. 21
Cost. Invero, l’unico obiettivo del reo è quello di ledere l’identità morale e l’onorabilità della vittima. Per questo motivo, non deve indurre in errore la circostanza che la condotta descritta dall’art. 612-ter verrà (esclusivamente) posta in essere utilizzando mezzi di comunicazione, deputati alla trasmissione del pensiero. Infatti, l’Autore ritiene che il fondamento costituzionale dell’art. 612-ter c.p. è da rinvenirsi negli artt. 2, 3 e 13 (intesa quale libertà di autodeterminarsi) Cost., mentre la libertà di corrispondenza e la libertà di manifestazione del pensiero non vengono compresse dal reato in esame.The paper concerns the relationship between the crime of “Illicit distribution of sexually explicit images or videos” (Article 612-ter of the Italian Criminal Code) and the constitutional freedoms of correspondence and expression of thought.
Specifically, the Author reflects on whether the offence under art. 612-ter affects the freedoms pursuant to Article 15 and Article 21 of the Constitution. Indeed, the offender’s sole objective is to damage the victim’s moral identity and reputation. For this reason, we should not be misled by the fact that the conduct targeted in Article 612-ter may (exclusively) be implemented using means of communication designed for the transmission of thought. In fact, the Author believes that the constitutional foundation for art. 612-ter of the Italian Criminal Code is to be found in Articles 2, 3 and 13 of the Constitution (regarding the freedom of self-determination), while the freedom of correspondence and freedom of expression of thought are not restricted by the crime in question
A historia e as histórias de Cosimo
No full textPublicado em 1957 e inserido na trilogia I nostri antenati em 1965, Il barone rampante de Italo Calvino retrata as mudanças ocorridas no século XVIII na Europa, através da insólita vida de Cosimo, o barão que viveu sobre as árvores. Cosimo pode ser lido como um microcosmo do período em questão e, através da narrativa de suas aventuras, é possível traçar um percurso intelectual do homem ocidental. Este trabalho tem por objetivos discutir as relações entre Ficção e História, através das análises estrutural e discursiva de Il barone rampante, e analisar a formação intelectual e de valores do protagonista, paralela a uma genealogia do romance, apresentada na obra. Para tanto, verificaremos a relação dos romances aos quais Il barone rampante faz referências com o crescimento do público leitor e com o nascimento e o amadurecimento do gênero literário que surge no berço da sociedade burguesa: o romance. Também serão discutidas as influências das obras iluministas no pensamento e nas ações do personagem, uma vez que, na figura de Cosimo, vemos um personagem leitor, inventor, filósofo e contador de histórias. Para o estudo da relação entre Ficção e História, privilegiaremos a reflexão metaficcional que aparece na voz do narrador, numa discussão sobre o papel do historiador e do escritor literário e a tênue linha que os separa. Aliada a essa discussão, verificaremos o posicionamento estético e ideológico de Calvino diante de suas reflexões ensaísticas sobre o papel da literatura e do intelectual na contemporaneidade.Published in 1957 and joined to the Our Ancestors trilogy in 1965, The Baron in the Trees, by Italo Calvino, is a portrait of the changes in Europe during the 18th century, shown through the preposterous life of Cosimo, the baron that lived in the trees. Cosimo can be interpreted as a microcosm of the 18th century, and the tale of his adventures is a way to trace the intellectual journey of the West. The present work aims to discuss the relationship between history and fiction with the structural and discursive analysis of The Baron in the Trees, and to analyze the intellectual and moral coming of age of the main character, along with a genealogy of the novel, presented in Calvino's work. To that end, we will show the relationship between the novels The Baron in the Trees alludes to and the growth of the readership, the birth and the coming of age of the literary genre that is part of the origins of the bourgeois society: the novel. We will also discuss the impact of the Enlightenment on the thoughts and actions of the main character, since, in the person of Cosimo, we see a reader, an inventor, a philosopher and a storyteller. To study the relationship between fiction and history, we shall prioritize the metafictional reflexion that appears in the narrator's voice, in a discussion about the role of the historian and the author and the thin line that keeps them apart. We will also investigate Calvino's aesthetic and ideological position in his reflexions on the role of literature and of the scholars in the modern world.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES
A historia e as histórias de Cosimo
No full textPublicado em 1957 e inserido na trilogia I nostri antenati em 1965, Il barone rampante de Italo Calvino retrata as mudanças ocorridas no século XVIII na Europa, através da insólita vida de Cosimo, o barão que viveu sobre as árvores. Cosimo pode ser lido como um microcosmo do período em questão e, através da narrativa de suas aventuras, é possível traçar um percurso intelectual do homem ocidental. Este trabalho tem por objetivos discutir as relações entre Ficção e História, através das análises estrutural e discursiva de Il barone rampante, e analisar a formação intelectual e de valores do protagonista, paralela a uma genealogia do romance, apresentada na obra. Para tanto, verificaremos a relação dos romances aos quais Il barone rampante faz referências com o crescimento do público leitor e com o nascimento e o amadurecimento do gênero literário que surge no berço da sociedade burguesa: o romance. Também serão discutidas as influências das obras iluministas no pensamento e nas ações do personagem, uma vez que, na figura de Cosimo, vemos um personagem leitor, inventor, filósofo e contador de histórias. Para o estudo da relação entre Ficção e História, privilegiaremos a reflexão metaficcional que aparece na voz do narrador, numa discussão sobre o papel do historiador e do escritor literário e a tênue linha que os separa. Aliada a essa discussão, verificaremos o posicionamento estético e ideológico de Calvino diante de suas reflexões ensaísticas sobre o papel da literatura e do intelectual na contemporaneidade.Published in 1957 and joined to the Our Ancestors trilogy in 1965, The Baron in the Trees, by Italo Calvino, is a portrait of the changes in Europe during the 18th century, shown through the preposterous life of Cosimo, the baron that lived in the trees. Cosimo can be interpreted as a microcosm of the 18th century, and the tale of his adventures is a way to trace the intellectual journey of the West. The present work aims to discuss the relationship between history and fiction with the structural and discursive analysis of The Baron in the Trees, and to analyze the intellectual and moral coming of age of the main character, along with a genealogy of the novel, presented in Calvino's work. To that end, we will show the relationship between the novels The Baron in the Trees alludes to and the growth of the readership, the birth and the coming of age of the literary genre that is part of the origins of the bourgeois society: the novel. We will also discuss the impact of the Enlightenment on the thoughts and actions of the main character, since, in the person of Cosimo, we see a reader, an inventor, a philosopher and a storyteller. To study the relationship between fiction and history, we shall prioritize the metafictional reflexion that appears in the narrator's voice, in a discussion about the role of the historian and the author and the thin line that keeps them apart. We will also investigate Calvino's aesthetic and ideological position in his reflexions on the role of literature and of the scholars in the modern world.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Secretaria de Educaçã
Una lettera odeporica di Cosimo De Giorgi
Get PDFEnWhile the first half of the nineteenth century saw the inauguration of a penchant for local and circumscribed itineraries, Cosimo De Giorgi, in a long and detailed letter to a friend from Pisa (later given to the press), sets out his brief experience of a railroad journey from Bari to Taranto. It is a report that skillfully combines technical and naturalistic information about the territory with sketchy descriptions of the places, but it is also embellished with notes on the author's state of mind and with his erudite observations. The essay aims to frame this lesser-known text by the eclectic Salento author within the framework of nineteenth-century odeporics by noting its characters and specificities.ItMentre nella prima metà dell'Ottocento si inaugura l'inclinazione per il percorso di itinerari locali e circoscritti, Cosimo De Giorgi, in una lunga e dettagliata lettera ad un amico pisano poi data alle stampe, espone la sua breve esperienza di un viaggio in ferrovia da Bari a Taranto. Si tratta di una relazione che coniuga sapientemente informazioni di carattere tecnico e naturalistico sul territorio a descrizioni bozzettistiche dei luoghi, ma che è anche impreziosita da appunti sullo stato d'animo dell'autore e dalle sue erudite osservazioni. Il saggio si propone di inquadrare questo testo meno noto dell'eclettico autore salentino nell'alveo dell'odeporica ottocentesca rilevandone caratteri e specificità
A historia e as histórias de Cosimo
No full textPublicado em 1957 e inserido na trilogia I nostri antenati em 1965, Il barone rampante de Italo Calvino retrata as mudanças ocorridas no século XVIII na Europa, através da insólita vida de Cosimo, o barão que viveu sobre as árvores. Cosimo pode ser lido como um microcosmo do período em questão e, através da narrativa de suas aventuras, é possível traçar um percurso intelectual do homem ocidental. Este trabalho tem por objetivos discutir as relações entre Ficção e História, através das análises estrutural e discursiva de Il barone rampante, e analisar a formação intelectual e de valores do protagonista, paralela a uma genealogia do romance, apresentada na obra. Para tanto, verificaremos a relação dos romances aos quais Il barone rampante faz referências com o crescimento do público leitor e com o nascimento e o amadurecimento do gênero literário que surge no berço da sociedade burguesa: o romance. Também serão discutidas as influências das obras iluministas no pensamento e nas ações do personagem, uma vez que, na figura de Cosimo, vemos um personagem leitor, inventor, filósofo e contador de histórias. Para o estudo da relação entre Ficção e História, privilegiaremos a reflexão metaficcional que aparece na voz do narrador, numa discussão sobre o papel do historiador e do escritor literário e a tênue linha que os separa. Aliada a essa discussão, verificaremos o posicionamento estético e ideológico de Calvino diante de suas reflexões ensaísticas sobre o papel da literatura e do intelectual na contemporaneidade.Published in 1957 and joined to the Our Ancestors trilogy in 1965, The Baron in the Trees, by Italo Calvino, is a portrait of the changes in Europe during the 18th century, shown through the preposterous life of Cosimo, the baron that lived in the trees. Cosimo can be interpreted as a microcosm of the 18th century, and the tale of his adventures is a way to trace the intellectual journey of the West. The present work aims to discuss the relationship between history and fiction with the structural and discursive analysis of The Baron in the Trees, and to analyze the intellectual and moral coming of age of the main character, along with a genealogy of the novel, presented in Calvino's work. To that end, we will show the relationship between the novels The Baron in the Trees alludes to and the growth of the readership, the birth and the coming of age of the literary genre that is part of the origins of the bourgeois society: the novel. We will also discuss the impact of the Enlightenment on the thoughts and actions of the main character, since, in the person of Cosimo, we see a reader, an inventor, a philosopher and a storyteller. To study the relationship between fiction and history, we shall prioritize the metafictional reflexion that appears in the narrator's voice, in a discussion about the role of the historian and the author and the thin line that keeps them apart. We will also investigate Calvino's aesthetic and ideological position in his reflexions on the role of literature and of the scholars in the modern world.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES
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