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Influence of diluent alkyl substitution on the extraction of Am(III) and Eu(III) by a 6,6’-bis(1,2,4-triazin-3-yl)-2,2’-bipyridine ligand dissolved in alkylated cyclohexanone Diluents
No full textSeveral alkylated cyclohexanones were investigated as potential diluents for the selective extraction of Am(III) from Eu(III) from nitric acid solutions by the CyMe4-BTBP ligand. No significant extraction of either of the metal ions was observed for these diluents themselves. In the extractions from 1 M HNO3, 3-methylcyclohexanone and 4-methylcyclohexanone gave comparable results to cyclohexanone whereas in the extractions from 4 M HNO3, 2-methylcyclohexanone, 3-methylcyclohexanone and 4-methylcyclohexanone all gave superior results. For the monomethylated diluents, DAm and SFAm/Eu decreased in the order of alkyl substitution 2 > 4 ~ 3. However, alkyl substitution of cyclohexanone significantly slows down the extraction kinetics compared to cyclohexanone, and the position of alkyl substitution was found to play an important role in the solvents properties. 3-Methylcyclohexanone was identified as the most promising of the diluent
Real-time optimization of integrated subcooling transcritical CO2 heat pump water heater via phasor extreme seeking control (ESC)
No full textThis article presents a novel approach to real-time optimization of integrated subcooling transcritical CO2 heat pump water heater using the phasor ESC. Compared to the traditional dither-demodulation ESC, the phasor ESC shows improvements in optimization efficiency. A dynamic model of the heat pump system with high fidelity was developed in Dymola. Starting from a single phasor ESC for discharge pressure, we proposed practical guidelines for tuning the ESC parameters, such as the dither signal frequency, which significantly shortens the searching process by almost half. The effectiveness and adaptability of the multi-variable phasor ESC were demonstrated under various operating conditions, including time-varying disturbances such as ambient temperature. Simulation results showed that the phasor ESC outperforms both standard strategies and classic ESC in terms of performance
Discovery of Pyrazole-5-yl-amide Derivatives Containing Cinnamamide Structural Fragments as Potential Succinate Dehydrogenase Inhibitors
No full textTo
promote the development of novel agricultural succinate dehydrogenase
inhibitor (SDHI) fungicides, we introduced cinnamamide and nicotinamide
structural fragments into the structure of pyrazol-5-yl-amide by carbon
chain extension and scaffold hopping, respectively, and synthesized
a series of derivatives. The results of the biological activity assays
indicated that most of the target compounds exhibited varying degrees
of inhibitory activity against the tested fungi. Notably, compounds G22, G28, G34, G38,
and G39 exhibited excellent in vitro antifungal activities
against Valsa mali with EC50 values of 0.48, 0.86, 0.57, 0.73, and 0.87 mg/L, respectively, and
this result was significantly more potent than boscalid (EC50 = 2.80 mg/L) and closer to the specialty control
drug tebuconazole (EC50 = 0.30 mg/L). Compounds G22 and G34 also exhibited excellent in vivo
protective and curative effects against V. mali at 40 mg/L. The SEM and TEM observations indicated that compounds G22 and G34 may affect normal V. mali mycelial morphology as well as the cellular
ultrastructure. Molecular docking analysis results indicated that G22 and boscalid possessed a similar binding
mode to that of SDH, and detailed SDH inhibition assays validated
the feasibility of the designed compounds as potential SDH inhibitors.
Compounds G22 and G3 were selected for theoretical
calculations, and the terminal carboxylic acid group of this series
of compounds may be a key region influencing the antifungal activity.
Furthermore, toxicity tests on Apis mellifera l. revealed that compounds G22 and G34 exhibited low toxicity to A. mellifera l. populations. The above results demonstrated that these series
of pyrazole-5-yl-amide derivatives are promising for development as
potential low-risk drug-resistance agricultural SDHI fungicides
Poly[bis[chloridocopper(I)]-μ4-1,4-bis[1-(3-pyridylmethyl)-1H-benzimidazol-2-yl]butane]
No full textThe title CuI coordination polymer, [Cu2Cl2(C30H28N6)]n, was obtained by reaction of CuCl2·2H2O and 1,4-bis[1-(3-pyridylmethyl)-1H-benzimidazol-2-yl]butane. Each CuI cation is three-coordinated by a ClN2 donor set. The anion acts as a tetradentate ligand, linking CuI centres into a polymeric chain
Doctor-family-patient relationship: The Chinese paradigm of informed consent
No full textBioethics is a subject far removed from the Chinese, even from many Chinese medical students and medical professionals. In-depth interviews with eighteen physicians, patients, and family members provided a deeper understanding of bioethical practices in contemporary China, especially with regard to the doctor-patient relationship (DPR) and informed consent. The Chinese model of doctor-family-patient relationship (DFPR), instead of DPR, is taken to reflect Chinese Confucian cultural commitments. An examination of the history of Chinese culture and the profession of medicine in China is used to disclose the deep roots of these commitments. The author predicts that the DFPR model will further develop in China but that it will maintain its Chinese character.EthicsSocial Sciences, BiomedicalPubMedCPCI-SSH(ISSHP)SSCI4
A Codeposition Route to CuI−Pyridine Coordination Complexes for Organic Light-Emitting Diodes
No full textWe demonstrate a new approach for utilizing CuI coordination complexes as emissive layers in organic light-emitting diodes that involves in situ codeposition of CuI and 3,5-bis(carbazol-9-yl)pyridine (mCPy). With a simple three-layer device structure, pure green electroluminescence at 530 nm from a Cu(I) complex was observed. A maximum luminance and external quantum efficiency (EQE) of 9700 cd/m2 and 4.4%, respectively, were achieved. The luminescent species was identified as [CuI(mCPy)2]2 on the basis of photophysical studies of model complexes and X-ray absorption spectroscopy
A Codeposition Route to CuI−Pyridine Coordination Complexes for Organic Light-Emitting Diodes
No full textWe demonstrate a new approach for utilizing CuI coordination complexes as emissive layers in organic light-emitting diodes that involves in situ codeposition of CuI and 3,5-bis(carbazol-9-yl)pyridine (mCPy). With a simple three-layer device structure, pure green electroluminescence at 530 nm from a Cu(I) complex was observed. A maximum luminance and external quantum efficiency (EQE) of 9700 cd/m2 and 4.4%, respectively, were achieved. The luminescent species was identified as [CuI(mCPy)2]2 on the basis of photophysical studies of model complexes and X-ray absorption spectroscopy
{μ-Bis(1-methylimidazol-2-yl)methane-κ2N3:N3′}bis{[(1-methylimidazol-2-yl)methane-κ2N3,N3′]copper(I)} bis(trifluoromethanesulfonate)
No full textThe title compound, [Cu2(C9H12N4)3](CF3SO3)2, contains two CuI ions, three bis(1-methylimidazol-2-yl)methane (Me2BIM) ligands, and two trifluoromethanesulfonate anions in the asymmetric unit. Each CuI ion has a distorted trigonal-planar geometry and is coordinated by two N atoms from the Me2BIM ligand and another N atom from the Me2BIM that acts as a bridging ligand, another N atom of the bridging Me2BIM being linked to the second CuI ion. The imidazole rings of Me2BIM form intramolecular π–π stacking interactions [centroid–centroid distances = 3.445 (2) and 3.547 (2) Å]
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