10,444 research outputs found
On Vulnerability: Distinguishing Differences Between the Knight of Faith and the Knight of Resignation in Kierkegaard’s Fear and Trembling
No full textCHRISTOPHER G. CROSS: On Vulnerability: Distinguishing Differences Between the Knight of Faith and the Knight of Resignation in Kierkegaard’s Fear and
Trembling
(Under the direction of William Lawhead)
In Søren Kierkegaard’s work, Fear and Trembling, he describes two kinds of individuals, which he calls the knight of faith and the knight of infinite resignation. The purpose of this thesis is to consider the differences between the two. Several scholars of the work identify different characteristics that distinguish the knight of faith and the knight of infinite resignation. These characteristics include care (Mooney), courage (Carlisle), and autonomy (Lippitt). This thesis uses those three notions to suggest that another difference between the knight of faith and knight of infinite resignation is the characteristic of vulnerability
"Historian of the spirit": an introduction to the life and ideas of Christopher H. Dawson, 1889-1970
No full textWhat follows is an intellectual biography of the English Catholic historian Christopher Henry Dawson (1889-1970). If there is one overarching thesis to this dissertation, it is that Dawson's place within the history of Britain and the United States and within the historical academy in general has been hitherto underappreciated as a result of unfair categorization of his work by critics, and equally unhelpful credulous assessments imd subsequent politicization of his scholarship by overzealous admirers. Even though his perspectives will probably never be completely embraced by the historical academy due to current trends in historiography, it is hoped that this dissertation will demonstrate that Dawson’s scholarship is deserving of study because of the breadth of his intellectual and practical activity in Britain during the twentieth century, and his groundbreaking role in identifying the importance of culture and religious belief to historiography. The introduction includes a review of the most important secondary literature about Dawson that will be used throughout the work. The main text of the dissertation develops chronologically, and is in eight parts, each part representing a distinct phase of Dawson's life. Part Chie (1889-1914) examines the formative years of his childhood, his education, his conversion to the Roman Catholic Church, and how his experiences formed the basis for his opinions about history, religion, and world around him. Part Two (1915-1929) explores the schools of thought that shaped Dawson’s ideas as a young scholar, and the ideas expressed in his first two books. Part Three (1930-1934) represents the most active time of Dawson's career, and the period during which he became a widely read Catholic intellectual and historian of Europe. Part Four (1935-1939) examines Dawson's commentaries on European political movements during the 1930ร. Part Five (1940-1945) discusses Dawson's role as the vice-president of die wartime ecumenical movement 'The Sword of the Spirit', as well as his book written at the height of the Movement's success. Part Six (1946-1952) covers Dawson's ideas from his Gifford Lectures, and his interest in American Catholicism. Part Seven (1953-1962) covers Dawson's vision for American Catholics and education, and his position at Harvard University, which he held from 1958 until a series of strokes forced him to retire, and return to England in 1962. Part Eight (1963-1970) briefly discussed the events of the last years of his life. The conclusion serves as a summary of his contribution and legacy as a major twentieth-century intellectual
"The 'fightin'est' Canadian general:" Brigadier Christopher Vokes and his approach to military command, June 1942 -- August 1943
No full textThis thesis evaluates the manner in which Brigadier Christopher Yokes dealt with the technical and human aspects of command while commanding the 2nd Canadian Infantry Brigade from 25 June 1942 until the end of the Sicilian campaign in August 1943. It seeks to promote a greater understanding of brigade-level command and to rehabilitate Vokes's reputation as a commander, which has largely been based on certain negative personality traits. The author argues that Yokes was a successful commander because he maintained a good balance between technical skills such as planning and directing operations and his ability to understand, motivate, and lead soldiers, and because his actions were guided by a sound philosophy of command based on personal leadership and teamwork. These elements allowed Christopher Yokes to train and lead a highly effective and cohesive fighting force that defeated some of Germany's best troops in the physically demanding environment of the Sicilian battlefield
Explaining contextual influences on the dynamics of public management reforms: reflections on some ways forward
No full textAs summed up by Christopher Pollitt in a co-authored paper based on a wide analysis of both academic and grey literature on the impact of (new public management [NPM]-type) public management reforms in Europe, the development of scholarly knowledge about the understanding of contextual influences on the dynamics of public management reforms has led to the recognition that certain ‘factors’, properly positioned along time and scale dimensions, exert an influence in a certain direction (facilitate vs. prevent) on certain contents of public management reform (Pollitt and Dan, 2011, pp. 35–47). This state of the art leaves the question ‘how can we then move forward and better qualify causal patterns?’ yet to be fully addressed, as it does for related questions such as ‘how can we bridge the stream of research on public management reform trajectories in different countries2 (which is by definition at a ‘macro’ level of analysis3) with strands of research in public management which aim at comprehending causes and effects in public management by uncovering what happens at more ‘micro’ a level (for example, the stream of research on Public Service Motivation [PSM] – see Perry and Hondeghem, 2008 and Vandenabeele and Hondeghem, 2008 – focused on the motivational structure of individuals working for the public sector)?’
"The 'fightin'est' Canadian general:" Brigadier Christopher Vokes and his approach to military command, June 1942 -- August 1943
No full textThis thesis evaluates the manner in which Brigadier Christopher Yokes dealt with the technical and human aspects of command while commanding the 2nd Canadian Infantry Brigade from 25 June 1942 until the end of the Sicilian campaign in August 1943. It seeks to promote a greater understanding of brigade-level command and to rehabilitate Vokes's reputation as a commander, which has largely been based on certain negative personality traits. The author argues that Yokes was a successful commander because he maintained a good balance between technical skills such as planning and directing operations and his ability to understand, motivate, and lead soldiers, and because his actions were guided by a sound philosophy of command based on personal leadership and teamwork. These elements allowed Christopher Yokes to train and lead a highly effective and cohesive fighting force that defeated some of Germany's best troops in the physically demanding environment of the Sicilian battlefield
Cross Elasticity of Supply: As Big a Secret in Canada as It Is in the U.S.
No full textIn a prior study, the author determined that cross elasticity of supply is rarely discussed in intermediate microeconomics, and industrial organization textbooks used in U. S. universities. He did, however, find that the American judicial system has increasingly relied upon the concept in defining product markets. In the present paper, the author examines cross elasticity of supply in economics textbooks in Canadian universities. Similar to his prior study, the author found virtually no mention of the concept in the Canadian textbooks. However, unlike the prior study, he found no appreciable reliance upon cross elasticity of supply in defining product markets by Canadian courts. Though perplexed over its lack of academic discussion, the author is encouraged by the deference paid to cross elasticity of supply by American courts.
Founders: Christopher Taylor
No full text\ua9 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. ‘Founders’ is an intermittent series of short, critical appreciations of scholars, researchers and others whose work and ideas, mainly in Britain, have made particularly sweeping, influential and foundational contributions to the development of historically- and archaeologically-informed landscape studies. This latest addition to the series concerns Christopher Taylor, whose death on 28th May 2021 was noted in the Landscapes editorial in issue 21.2
Pannexin-1 and P2X7-Receptor Are Required for Apoptotic Osteocytes in Fatigued Bone to Trigger RANKL Production in Neighboring Bystander Osteocytes
No full textOsteocyte apoptosis is required to induce intracortical bone remodeling after microdamage in animal models, but how apoptotic osteocytes signal neighboring “bystander” cells to initiate the remodeling process is unknown. Apoptosis has been shown to open pannexin-1 (Panx1) channels to release adenosine diphosphate (ATP) as a “find me” signal for phagocytic cells. To address whether apoptotic osteocytes use this signaling mechanism, we adapted the rat ulnar fatigue-loading model to reproducibly introduce microdamage into mouse cortical bone and measured subsequent changes in osteocyte apoptosis, receptor activator of NF-kB ligand (RANKL) expression and osteoclastic bone resorption in wild-type (WT; C57Bl/6) mice and in mice genetically deficient in Panx1 (Panx1KO). Mouse ulnar loading produced linear microcracks comparable in number and location to the rat model. WT mice showed increased osteocyte apoptosis and RANKL expression at microdamage sites at 3 days after loading and increased intracortical remodeling and endocortical tunneling at day 14. With fatigue, Panx1KO mice exhibited levels of microdamage and osteocyte apoptosis identical to WT mice. However, they did not upregulate RANKL in bystander osteocytes or initiate resorption. Panx1 interacts with P2X7R in ATP release; thus, we examined P2X7R-deficient mice and WT mice treated with P2X7R antagonist Brilliant Blue G (BBG) to test the possible role of ATP as a find-me signal. P2X7RKO mice failed to upregulate RANKL in osteocytes or induce resorption despite normally elevated osteocyte apoptosis after fatigue loading. Similarly, treatment of fatigued C57Bl/6 mice with BBG mimicked behavior of both Panx1 KO and P2X7RKO mice; BBG had no effect on osteocyte apoptosis in fatigued bone but completely prevented increases in bystander osteocyte RANKL expression and attenuated activation of resorption by more than 50%. These results indicate that activation of Panx1 and P2X7R are required for apoptotic osteocytes in fatigued bone to trigger RANKL production in neighboring bystander osteocytes and implicate ATP as an essential signal mediating this process.Peer reviewe
The effects of estrogen deficiency on cortical bone microporosity and mineralization
No full textRecent studies have demonstrated matrix-mineral alterations in bone tissue surrounding osteocytes in estrogen-deficient animals.While cortical bone porosity has been shown to be a contributor to the mechanical properties of bone tissue, little analysis has been done to investigate the effects of estrogen deficiency on bone's microporosities, including the vascular and osteocyte lacunar porosities. In this study we examined alterations in cortical bone microporosity, mineralization, and cancellous bone architecture due to estrogen deficiency in the ovariectomized rat model of postmenopausal osteoporosis. Twenty-week-old female Sprague–Dawley rats were subjected to either ovariectomy or sham surgery. Six weeks post-surgery tibiae were analyzed using high-resolution micro-CT, backscattered electron imaging, nanoindentation, and dynamic histomorphometry. Estrogen deficiency caused an increase in cortical bone vascular porosity, with enlarged vascular pores and little change in tissue mineral density in the proximal tibial metaphysis. Measurements of cancellous architecture corresponded to previous studies reporting a decrease in bone volume fraction, an increase in trabecular separation, and a decrease in trabecular number in the proximal tibia due to estrogen deficiency. Nanoindentation results showed no differences in matrix stiffness in osteocyte-rich areas of the proximal tibia of estrogen-deficient rats, and bone labeling and backscattered electron imaging showed no significant changes in mineralization around the vascular pores. The findings demonstrate local surface alterations of vascular pores due to estrogen deficiency. An increase in cortical vascular porosity may diminish bone strength as well as alter bone mechanotransduction via interstitial fluid flow, both of which could contribute to bone fragility during postmenopausal osteoporosis.Peer reviewe
Thermally responsive core-shell microparticles and cross-linked networks based on nitrone chemistry
No full textComplex cross-linked soluble architectures with molecular weights ranging from 25 000 to 71 000 g mol(-1) and polydispersities (PDIs) ranging from 2.5 to 8.1 are generated using nitrone mediated chemistry. These cross-linked architectures are subsequently cleaved into their constituting fragments, i.e. linear chains with molecular weights ranging from 36 000 to 40 000 g mol(-1) and a PDI of 2.0 or network fragments with molecular weights ranging from 28 000 to 30 000 g mol(-1) and PDIs from 2.5 to 3.7, respectively. The cleavage into linear chains or network fragments depends on the pathway of network formation. Nitrone mediated reactions are also applied for the synthesis of microspheres. Conventional distillation precipitation polymerization was performed in the presence of a nitrone, leading to uniform microspheres with diameters ranging from 2.2 to 2.4 mu m. These microspheres feature alkoxyamine functionalities throughout their interior and on their surface. The alkoxyamine functionality on the surface is employed in a subsequent nitroxide mediated polymerization (NMP) with N-isopropylacrylamide (NiPAAm) in a ‘grafting from' approach to generate pNiPAAm on the surface of the microspheres. The resulting stimuli-responsive core-shell microspheres are characterized via SEM, XPS, elemental analysis as well as turbidity measurements. The characterization methods confirm the presence of a stimuli-responsive layer of pNiPAAm on the microspheres' surface
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