354 research outputs found
Effect of beta-amyloid in vivo infusion on dopamine release in absence of lesional effects
No full text
PREDA: an R-package to identify regional variations in genomic data
No full textSUMMARY:Chromosomal patterns of genomic signals represent molecular fingerprints that may reveal how the local structural organization of a genome impacts the functional control mechanisms. Thus, the integrative analysis of multiple sources of genomic data and information deepens the resolution and enhances the interpretation of stand-alone high-throughput data. In this note, we present PREDA (Position RElated Data Analysis), an R package for detecting regional variations in genomics data. PREDA identifies relevant chromosomal patterns in high-throughput data using a smoothing approach that accounts for distance and density variability of genomics features. Custom-designed data structures allow efficiently managing diverse signals in different genomes. A variety of smoothing functions and statistics empower flexible and robust workflows. The modularity of package design allows an easy deployment of custom analytical pipelines. Tabular and graphical representations facilitate downstream biological interpretation of results.AVAILABILITY:PREDA is available in Bioconductor and at http://www.xlab.unimo.it/PREDA
PREDA: An R-package to identify regional variations in genomic data
No full textChromosomal patterns of genomic signals represent molecular ngerprints that may reveal how the local structural organization of a genome impacts the functional control mechanisms. Thus, the integrative analysis of multiple sources of genomic data and information deepens the resolution and enhances the interpretation of stand-alone high-throughput data. In this note, we present PREDA (Position RElated Data Analysis), an R package for detecting regional variations in genomics data. PREDA identies relevant chromosomal patterns in high-throughput data using a smoothing approach that accounts for distance and density variability of genomics features. Custom-designed data structures allow efciently managing diverse signals in different genomes. A variety of smoothing functions and statistics empower exible and robust workows. The modularity of package design allows an easy deployment of custom analytical pipelines. Tabular and graphical representations facilitate downstream biological interpretation of results. © The Author 2011. Published by Oxford University Press. All rights reserved
Reuse of Dredged Sediments in Cut-Offs
No full textAddition of dredged sediments in cementitious mixtures was investigated to be used in vertical and horizontal barriers for sediment confined disposal facilities or for reclaimed near-shore lands.
Uncontaminated dredged sediments were added in different contents to typical cement-bentonite mixtures and to a patented cementitious mixture. Excellent hydraulic performance was obtained on all the mixtures (prepared in the laboratory) containing the sediments when permeated with tap water. Column tests performed using sea water as permeant showed that the mixtures can guarantee a good performance in the long term, depending on their components and dosages
The Hegemonic Gaze and East-Central Europe - Challenging the Totalitarian Paradigm
No full textThe chapter introduces the notion of the "hegemonic gaze" in relation to the representation of East-Central Europe, demonstrating how the artist becomes interpellated as a regional subject, becoming simultaneously included and othered. It begins by examining the complexities involved in defining the region and the power dynamics involved in naming and being named. The author argues that different terms produce specific subject positions, reinforcing certain narratives about the region and foregrounding the end of communism and the failure of the socialist project.
Through the lens of Stuart Hall's theory of encoding and decoding, the chapter explores how exhibitions and artworks depicting socialist monuments and architecture often become simplified and reinterpreted within the global art discourse. The author shows how the ‘‘hegemonic gaze’’ reinforces existing narratives and imposes meanings. Despite artists' efforts to engage with the complexities of the past, their work is often interpellated within predetermined frameworks that limit its interpretation
Adversarial Authorship Attribution in Open-Source Projects
No full textOpen-source software is open to anyone by design, whether it is a community of developers, hackers or malicious users. Authors of open-source software typically hide their identity through nicknames and avatars. However, they have no protection against authorship attribution techniques that are able to create software author profiles just by analyzing software characteristics. In this paper we present an author imitation attack that allows to deceive current authorship attribution systems and mimic a coding style of a target developer. Withing this context we explore the potential of the existing attribution techniques to be deceived. Our results show that we are able to imitate the coding style of the developers based on the data collected from the popular source code repository, GitHub. To subvert author imitation attack, we propose a novel author obfuscation approach that allows us to hide the coding style of the author. Unlike existing obfuscation tools, this new obfuscation technique uses transformations that preserve code readability. We assess the effectiveness of our attacks on several datasets produced by actual developers from GitHub, and participants of the GoogleCodeJam competition. Throughout our experiments we show that the author hiding can be achieved by making sensible transformations which significantly reduce the likelihood of identifying the author’s style to 0% by current authorship attribution systems
Acute beta-amyloid administration disrupts the cholinergic control of dopamine release in the nucleus accumbens
No full textThe clinical presentation of Alzheimer’s disease is characterized by memory deficits but it also involves the impairment of several
cognitive functions. Some of these cognitive and executive functions are mediated by limbic areas and are regulated by dopaminergic
neurotransmission. Furthermore, literature data suggest that b-amyloid (Ab) can influence synaptic activity in absence of neurotoxicity
and in particular can impair cholinergic modulation of other neurotransmitter actions. In the present study, we evaluated whether small
concentrations of Ab could disrupt cholinergic control of dopamine (DA) release in nucleus accumbens using in vivo (brain dialysis) and in
vitro (isolated synaptosomes) models. The cholinergic agonist carbachol (CCh) greatly enhanced DA release from dopaminergic nerve
endings in nucleus accumbens both in vivo and in vitro. This effect was mainly exerted on muscarinic receptors because it was inhibited by
the muscarinic antagonist atropine and it was unaffected by the nicotinic antagonist mecamylamine. Also the nicotinic agonists epibatidine
and nicotine evoked a dopaminergic outflow in nucleus accumbens, which, however, was lower. Ab 1–40 in absence of neurotoxicity
fully inhibited the DA release evoked by CCh and only marginally affected the DA release evoked by epibatidine. The PKC inhibitor
GF109203X mimicked the effect of Ab on DA release and, in turn, Ab impaired PKC activation by CCh. We can suggest that, in nucleus
accumbens, Ab disrupted in vivo and in vitro cholinergic control of DA release by acting on muscarinic transduction machinery.
Neuropsychopharmacology (2008) 33, 1062–1070; doi:10.1038/sj.npp.1301485; published online 20 June 2007
Keywords: Alzheimer’s disease; b-amyloid; dopamine; carbachol; cholinergic receptors; nucleus accumben
Matlab per le applicazioni economiche e finanziarie
No full textMatlab per: risoluzione di equazioni differenziali, sistemi, modelli di Solow, Samuelson, Goodwin, Preda- Predatore. Istogrammi, regressione lineare. Ottimizzazione libera e vincolata, metodi iterativi, modelli di selezione del portafoglio, VaR.Matlab for solving differential equations, systems. Models of Solow, Samuelson, Goodwin. Prey-predator. Histograms, linear regression. Constrained and unconstrained optimization, iterative methods. Portfolio optimization models, VaR
- …
