130,928 research outputs found
Carcinoid tumors of the lung and multimodal therapy
No full textAIM:
To report our experience with bronchial carcinoids.
METHODS:
From January 1990 to March 2003 we treated 42 such patients, 30 females and 12 males. All patients underwent preoperative total body computed tomography (CT), total body In-111 octreotide scintigraphy, and SPECT of the thorax, with evaluation of serum levels of CEA, CgA, NSE, and urinary 5-HIAA. Diagnosis was obtained in 28 patients with fibre-optic bronchoscopy and in 14 patients with CT-guided trans-thoracic needle biopsy.
RESULTS:
There were 26 typical and 16 atypical carcinoids. 30 lobectomies, 5 bilobectomies, 6 wedge resections, and 1 pneumonectomy were carried out. The 3-year and the 5-year survival rates in the typical and atypical carcinoid groups were 100 % and 96 % vs. 81 % and 68 %, respectively (p < 0.001).
CONCLUSIONS:
Long-term survival is based on histological completeness of surgical treatment. Octreotide scintigraphy and SPECT document N (1) and N (2) precisely
Use of demiralized bone matrix and plate for sternal stabilization after traumatic dislocation
No full textTraumatic sternal segments dislocation is a rare pathology that is on the increase because of road accidents. Ideal treatment is controversial as it is a benign non-life-threatening lesion. The few cases reported in the literature do not shed light on any preferred procedure. In the present study, three patients were treated by surgical steel monofilament and eight by titanium screws and plates and demineralized bone matrix. The reduced hospitalization, rapid functional recovery, and excellent aesthetic results of the titanium patients make use of the surgical approach inevitable
Multimodal treatment of osteosarcoma lung metastases
No full textOBJECTIVE:
The diagnostic procedures, role of surgery and multimodal treatment for osteosarcoma pulmonary metastases are examined.
METHODS:
From January 2000 to June 2005, we observed 35 patients with osteogenic repetitions. Patients were studied by total-body computerised tomography (CT) and by thoracic single-photon emission computerised tomography (SPECT). Preoperative histological diagnosis was obtained by CT-guided transthoracic needle biopsy (23 cases) and fibre-optic bronchoscopy (12 cases).
RESULTS:
Four lower, 6 upper and 2 middle lobectomies were carried out using a thoracotomy approach. Video-assisted thoracoscopy was used in the other 23 patients who underwent 36 wedge resections. CT showed a sensitivity of 86 % and a specificity of 66 %; SPECT had a sensitivity of 80 % and a specificity of 100 %. Twenty-five patients are still living 25 +/- 11 months after the intervention.
CONCLUSIONS:
SPECT was demonstrated to offer a better result in the individualisation of secondary pulmonary nodules after primary osteosarcoma. The excision of all resectable lung metastases, integrated in a multidisciplinary strategy, offers good results in terms of survival
On Identifying Signatures of Positive Selection in Human Populations: A Dissertation
No full textAs sequencing technology continues to produce better quality genomes at decreasing costs, there has been a recent surge in the variety of data that we are now able to analyze. This is particularly true with regards to our understanding of the human genome—where the last decade has seen data advances in primate epigenomics, ancient hominid genomics, and a proliferation of human polymorphism data from multiple populations. In order to utilize such data however, it has become critical to develop increasingly sophisticated tools spanning both bioinformatics and statistical inference. In population genetics particularly, new statistical approaches for analyzing population data are constantly being developed—unfortunately, often without proper model testing and evaluation of type-I and type-II error. Because the common Wright-Fisher assumptions underlying such models are generally violated in natural populations, this statistical testing is critical. Thus, my dissertation has two distinct but related themes: 1) evaluating methods of statistical inference in population genetics, and 2) utilizing these methods to analyze the evolutionary history of humans and our closest relatives. The resulting collection of work has not only provided important biological insights (including some of the first strong evidence of selection on human-specific epigenetic modifications (Shulha, Crisci, Reshetov, Tushir et al. 2012, PLoS Bio), and a characterization of human-specific genetic changes distinguishing modern humans from Neanderthals (Crisci et al. 2011, GBE)), but also important insights in to the performance of population genetic methodologies which will motivate the future development of improved approaches for statistical inference (Crisci et al, in review).Bioinformatics and Computational Biolog
Evaluación de la actividad antibacteriana in vitro del extracto acuoso de hojas de sasahui (Leucheria daucifolia (D. DON) Crisci) frente a Staphylococcus aureus ATCC 25923 y Escherichia coli ATCC 25922, Arequipa 2015
No full textEn el presente trabajo de investigación se evaluó la actividad antibacteriana in vitro del
extracto acuoso de hojas de sasahui “Leucheria daucifolia (D. Don) Crisci” frente
Staphylococcus aureus ATCC 25923 y Escherichia coli ATCC 25922, que se desarrolló
en el laboratorio múltiple L-206 y el laboratorio de microbiología L-205 de la Universidad
Alas Peruanas Filial Arequipa entre los meses de marzo y agosto del 2015.
La muestra fue recolectada en la comunidad de Chivay, provincia de Caylloma, región
Arequipa y se identificó taxonómicamente en el Herbarium Areqvipense de la
Universidad Nacional de San Agustín (UNSA). Se determinó un porcentaje de
rendimiento de 24.44 % para el extracto acuoso de hojas de sasahui “Leucheria
daucifolia (D. Don) Crisci” obtenido por el método de decocción. El análisis fitoquímico
preliminar del extracto acuoso de hojas de sasahui “Leucheria daucifolia (D. Don) Crisci”
evidenció la presencia de taninos, flavonoides, azúcares reductores y alcaloides; para
el estudio de la actividad antibacteriana in vitro del extracto acuoso se utilizó cepas de
Staphylococcus aureus ATCC 25923 y Escherichia coli ATCC 25922.
Los resultados de la concentración mínima inhibitoria (CMI) del extracto acuoso de hojas
de sasahui “Leucheria daucifolia (D. Don) Crisci” se estimó en 12.5 mg/mL para
Staphylococcus aureus ATCC 25923 y en 200 mg/mL para Escherichia coli ATCC
25922.En la determinación de la concentración mínima bactericida (CMB) del extracto
acuoso de hojas de sasahui “Leucheria daucifolia (D. Don) Crisci” se estimó en 25
mg/mL para Staphylococcus aureus ATCC 25923 y en 400 mg/mL para Escherichia coli
ATCC 25922, validando de esta manera la actividad antibacteriana de la planta
anteriormente mencionada para las dos bacterias de estudio
Multiple Endocrine Neoplasia with Pulmonary localization: a new protocol of approach
No full textWe present three patients with bronchial carcinoids, in which a more probed study emphasized the presence of three multiple endocrine neoplasia (MEN). Assessment included a total-body computerized tomography, a total-body single-photon emission computerized tomography by 111In-DTPA-D-Phe1 octreotide, and genetic map. Two patients presented an atypical MEN 1 and one patient showed an atypical MEN 1 with a familial medullary thyroid carcinoma. All patients were operated upon: two are still alive and one died 50 months after the first intervention. Precocious diagnosis of MEN permits a good long-term outcome
Videoassisted Thoracic Surgery vs plaural drainage in the management of the first epi-sode of primary spontaneous pneumothorax
No full textSacralizzare il profano. Pubblicità e comunicazione nelle organizzazioni artistico culturali
No full text- …
