2,149 research outputs found
Nuclear myosin VI enhances RNA polymerase II-dependent transcription
No full textAbstract not availableSarah Vreugde, Carmelo Ferrai, Annarita Miluzio, Ehud Hauben, Pier Carlo Marchisio, Massimo P. Crippa, Mario Bussi, Stefano Biff
Intraductal papillary mucinous neoplasms of the biliary and pancreatic ducts-A shape shifting outlook into an increasingly recognized disease.
No full textShape shifting, transformations and metamorphoses are common
and fascinating themes in mythology, literature and folklore
of different times. Among numerous examples of shape shifting, as
physicians it is apt to mention The Strange Case of Dr. Jekyll and Mr.
Hyde, by Robert Louis Stevenson, where the good Dr. Jekyll metamorphoses
into the evil Mr. Hyde. Dr. Jekyll and Mr. Hyde: same
character, two bodies with different morphology and with different
biological behaviours.
Those of us participating in the diagnosis and treatment of biliary
and pancreatic tumours may find a similar scenario when
considering the “strange case” of intraductal papillary mucinous
neoplasms (IPMNs). IPMNs of the pancreas (IPMNs-P) and of the biliary tract (IPMNs-B) were initially described in Japan in the 1980s with the name of “mucin-secreting cancer of the pancreas” and “mucin-hypersecreting intrahepatic biliary neoplasms”, respectively. However, while IPMNs-P are widely recognized since
the late 1990s, the term IPMN-B was used for the first time only in
200
Improving cytological diagnosis of pancreatic cysts: Is it clinically necessary or just the latest fashion?
No full textASO Author Reflections: Recurrence Following Post-neoadjuvant Pancreatectomy: How Can We Do Better?
No full textN/
Rectal indomethacin to prevent post-ERCP pancreatitis.
No full textIn their article on the prevention of pancreatitis after endoscopic retrograde cholangiopancreatography (ERCP), Elmunzer et al. (April 12 issue)1 underemphasized the fact that prophylactic pancreatic stents were placed in more than 80% of the study patients, among whom clinical suspicion of sphincter of Oddi dysfunction was predominant. Pancreatic stents significantly reduce rates of pancreatitis in high-risk patients,2,3 and the average rate reduction is larger than that in the current trial. In addition, the diameter of the stents influences rates of pancreatitis4,5; the diameter of the stents used by Elmunzer et al. was not reported
Extent of surgical resections for intraductal papillary mucinous neoplasms
No full textIntraductal papillary mucinous neoplasms (IPMNs) can involve the main pancreatic duct (MD-IPMNs) or its secondary branches (BD-IPMNs) in a segmental of multifocal/diffuse fashion. Growing evidence indicates that BD-IPMNs are less likely to harbour cancer and in selected cases these lesions can be managed non operatively. For surgery, clarification is required on: (1) when to resect an IPMN; (2) which type of resection should be performed; and (3) how much pancreas should be resected. In recent years parenchyma-sparing resections as well as laparoscopic procedures have being performed more frequently by pancreatic surgeons in order to decrease the rate of postoperative pancreatic insufficiency and to minimize the surgical impact of these operations. However, oncological radicality is of paramount importance, and extended resections up to total pancreatectomy may be necessary in the setting of IPMNs. In this article the type and extension of surgical resections in patients with MD-IPMNs and BD-IPMNs are analyzed, evaluating perioperative and long-term outcomes. The role of standard and parenchyma-sparing resections is discussed as well as different strategies in the case of multifocal neoplasms
Cultura e socializzazione nelle città europee del terzo millennio
No full textIl volume raccoglie contributi intorno al tema della riorganizzazione delle città, ispirandosi alla realtà multietnica e pluriculturale che contraddistingue le società europee contemporanee.
La capacità di accogliere le differenze, l’individuazione di valori fondativi per una convivenza nel rispetto reciproco, la ricerca di percorsi alternativi ai processi di integrazione finora sperimentati si evidenziano come problematiche che invitano a riflettere sul significato innovativo della “cultura della socializzazione”.
L’architettura e l’urbanistica, che dovranno nel prossimo millennio tradurre in “spazi” e “luoghi” queste nuove istanze, saranno chiamate a dare il loro contributo in direzione dei traguardi di civiltà che già oggi vengono prospettati da altri ambiti di espressione della cultura.
Il dialogo interreligioso e i processi evolutivi che contraddistinguono la filosofia, la sociologia, la storia, la letteratura saranno fonti insostituibili di riferimento per le scelte organizzative, formali e spaziali della città futura.
Gli scritti sono articolati in quattro sezioni tematiche: Città cultura e religione, Città socialità e progetto, Città e ospitalità, Cultura della comunicazione.
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Scritti di: Laura Balbo, Francesca Bonicalzi, Manuel Brullet i Tenas, Aurora Campus, Elena Cao, Franco Cardini, Paul Chemetov, Maria Antonietta Crippa, Gianfranco Dalmasso, Adriano De Maio, Jacques Derrida, Abdellatif El Kettani, Roberto Formigoni, Pierfranco Galliani, Giuseppe Laras, Gian Carlo Magnoli, Carlo Maria Martini, Antonio Piva, Robert Sproson, Cesare Stevan, Marzio Tremaglia, Massimo Venturi Ferriolo.
*****Contributi di Khaled Fouad Allam, Giovanni Anversa, Thar Ben Jelloun, Bice Biagi, Umberto Folena, Ricardo Franco Levi
A statistical methodology for the design of high-performance current steering DAC's
No full textRandom device variations are a key factor limiting the performances of high-resolution CMOS current steering D/A converters. In this paper a novel design methodology based on statistical modeling of MOS drain current has been developed. This technique requires firstly an estimation of mean value and autocorrelation function of a single stochastic process, which all the process/device variations are lumped in. Then a behavioral model of D/A converters has been developed. Finally, the statistical simulation of static performances (DNL and INL) has been carried out for different DAC architectures
A statistical MOS model for CAD of submicrometer analog IC's
No full textA novel statistical model for MOS transistor drain current has been developed that allows to explore IC's architectures and study the technological variations effects on the system performance without using time-consuming Monte Carlo simulations. Characterizing this model only requires a cheap and easy estimation of mean value and autocorrelation function of a single stochastic process describing all the process/device variations
A statistical methodology for the design of high-performance CMOS current-steering digital-to-analog converters
No full textWith the shrinking of device sizes, random device variations become a key factor limiting the performances of high-resolution complementary metal-oxide-semiconductor (CMOS) current-steering digital-to-analog converters (DACs). In this paper, we present a novel design methodology based on statistical modeling of MOS transistor drain current that allows designers to explore different DAC architectures and to study the effects of technological variations on system performance without using time-consuming Monte Carlo simulations. This technique requires as a first step the estimation of the mean value and the autocorrelation function of a single stochastic process. This stochastic process models the device drain current and summarizes all the random sources associated with the process/device variations since the current represents the effect of all of them. Subsequently, on the basis of such an approach, a behavioral model of current-steering DACs has been developed. Finally, the statistical simulation of static performances such as differential nonlinearity and integral nonlinearity has been carried out for different DAC architectures based on the behavioral model previously derived
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