613 research outputs found
Gino Severini, Polittico Garagnani
No full textScheda di catalogo del Polittico Garagnani di Gino Severini (1957
Giorgio De Chirico, La notte di Pericle
No full textScheda di catalogo del dipinto La notte di Pericle di Giorgio De Chirico (1926
Gino De Dominicis, Io a Roma
No full textScheda di catalogo del dipinto Io a Roma di Gino De Dominicis (1986
Giorgio Morandi. Natura morta, 1943
No full textScheda di catalogo del dipinto Natura morta di Giorgio Morandi (1943
Comparison between fixed appliance and clear aligners in the treatment of high angle patients with deep bite: a retrospective study
No full textManagement of Class II open bite in a growing patient using the Invisalign Teen system: A case report
No full textCorrection to: Size‐Dependent Enforcement, Tax Evasion and Dimensional Trap
No full textThe article “Size‐Dependent Enforcement, Tax Evasion and Dimensional Trap”, written by Raffaella Coppier, Elisabetta Michetti and Luisa Scaccia, was originally published electronically on the publisher’s internet portal on 05 July 2023 without open access. With the author(s)’ decision to opt for Open Choice the copyright of the article changed on 24 February 2024 to © The Author(s) 2024 and the article is forthwith distributed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made
Role of yUbp8 in Mitochondria and Hypoxia Entangles the Finding of Human Ortholog Usp22 in the Glioblastoma Pseudo-Palisade Microlayer
No full textKAT Gcn5 and DUB Ubp8 are required for respiration and mitochondria functions in budding yeast, and in this study we show that loss of respiratory activity is acquired over time. Interestingly, we show that absence of Ubp8 allows cells to grow in hypoxic conditions with altered mitophagy. Comparatively, the aggressive glioblastoma (GBM) multiforme tumor shows survival mechanisms able to overcome hypoxia in the brain. Starting from yeast and our findings on the role of Ubp8 in hypoxia, we extended our analysis to the human ortholog and signature cancer gene Usp22 in glioblastoma tumor specimens. Here we demonstrate that Usp22 is localized and overexpressed in the pseudo-palisade tissue around the necrotic area of the tumor. In addition, Usp22 colocalizes with the mitophagy marker Parkin, indicating a link with mitochondria function in GBM. Collectively, this evidence suggests that altered expression of Usp22 might provide a way for tumor cells to survive in hypoxic conditions, allowing the escape of cells from the necrotic area toward vascularized tissues. Collectively, our experimental data suggest a model for a possible mechanism of uncontrolled proliferation and invasion in glioblastoma
Elisabetta I come Cinzia: Una regina e il suo oceano
No full textThe defeat of the Spanish Armada in the Channel in 1588 turned ‘a weak and feeble woman’ into one of the most relevant characters of late 16th-century European history: Elizabeth I, the Tudor Queen, was considered a semi-divine creature whom the myth, by comparing her to Moon goddesses like Diana and Cinthia, had made known as Semper Eadem.
The identification of the queen with Cinthia became more and more evident after the events occurred in 1588, when she was hailed as the moon goddess par excellence in a series of texts written by her contemporaries. It was in that period, the last decades of the 16th century, that Sir Walter Ralegh, courtier, poet and seaman, wrote The Poems to Cynthia: a collection of short poems where Elizabeth I, the lady of the seas, is addressed as his beloved. The role of Elizabeth as Cinthia is evident above all in Ralegh’s Last Book of the Ocean to Cynthia, an unfinished poem where the author, desperate for being in disgrace, appeals to her clemency and addresses her as the empress of the ocean.La sconfitta della flotta spagnola nelle acque della Manica nel 1588 trasformò una donna sola e fragile in una delle figure più rilevanti della storia europea di fine XVI secolo: Elisabetta I Tudor divenne per i suoi sudditi una creatura semidivina che il mito, accostandola alle divinità lunari Diana e Cinzia, avrebbe consegnato alla Storia come Semper Eadem.
Pur essendo evidente già nei primi tempi del suo regno, l’identificazione della sovrana con Cinzia, la dea che governa i mari e i corsi d’acqua, si fa ancora più evidente dopo il 1588, quando si assiste ad una fioritura di testi che esaltano Elisabetta I come la dea lunare per eccellenza.
Sempre in quegli anni di fine XVI secolo, Sir Walter Ralegh compone The Poems to Cynthia: letterato, cortigiano e uomo di mare, Ralegh dedicherà il suo amore ad Elisabetta come Cinzia, signora dei mari. Il legame tra Elisabetta e l’oceano è soprattutto evidente in Last Book of the Ocean to Cynthia, un poemetto incompiuto in cui il poeta, caduto in disgrazia, riunisce sotto il nome di Cinzia, la donna e la regina, l’amante e la dea, trasformando così Elisabetta in dea e imperatrice dei mari
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