101,672 research outputs found
Structures of hydro-, chloro-, and bromo-substituted maleimides and 2,6-diaminopyridines, and of some of their 1 : 1 heterodimers
No full textThe crystal structures of a series of 3,4-diX-substituted maleimides and 3,5-diY-substituted-2,6-diaminopyridines (X, Y = H, Cl, Br) have been determined. Some of their hydrogen-bonded 1:1 heterodimers have also been synthesized and their crystal structures studied to investigate the influence of halogens on the crystal packing and to determine a possible role for halogen bonding. Single-crystal X-ray analysis of the crystals of the heterodimers revealed that the expected triple H-bonded structures were formed. This crystal engineering exercise has been partially successful, giving six mixed hydrogen- and (when possible) halogen-bonded compounds whose structures were found to be dependent on the nature and the position of the halogen substituents
Renal function recovery after nephrectomy or nephron-sparing surgery in children with unilateral renal tumor
No full textIntroduction Children with unilateral renal tumor (URT) and preoperative renal
dysfunction (PRD) may benefit from nephron-sparing surgery (NSS). To test this
hypothesis, we studied the outcome of baseline renal function after nephrectomy or
NSS among children with URT.
Materials and Methods Retrospective records review of children with URT who
underwent nephrectomy (25 children) or NSS (11 children) at our institution. We
analyzed the estimated glomerular filtration rate (eGFR) changes over time among
patients, stratified by both preoperative renal function (with or without PRD) and
surgical extent (NSS vs. nephrectomy). The primary end point was evaluation of
compensatory recovery of preoperative eGFR after surgery. Only children older than
2 years at surgery were included in the study. Renal dysfunction was defined as an
eGFR < 90 mL/min/1.73 m2.
Results After nephrectomy or NSS, patients with PRD presented, on average during
adolescence, a significant increase in eGFR, whereas patients without PRD presented, on
average during adolescence, a stable eGFR. However, after nephrectomy, 5 of 17 (29%)
and 7 of 8 (87%) adolescent patients with baseline eGFR or > 100 mL/min/1.73 m2,
respectively, achieved or maintained two-kidney eGFR values (T-KEV) (p 1⁄4 0.01). After
NSS, four adolescent patients with PRD and seven without PRD achieved or maintained
T-KEV.
Conclusion The majority of children with URT and low baseline eGFR present with an
impaired renal function recovery after nephrectomy and may benefit from NSS.
Collaborative studies are needed to support present findings
Letter, [Author unclear] to Paulina T. Merritt
No full textHandwritten letter to Paulina Merritt from an unknown author, October 1, 1876.
DNA damage repair and genetic polymorphisms: assessment of individual sensitivity and repair capacity
No full textPurpose: To study the repair capacity after X-ray irradiation in human peripheral blood cells of healthy subjects, in relation to their genotypes.
Methods and Materials: The peripheral blood of 50 healthy subjects was irradiated in vitro with 2Gy of X rays and the induced DNA damage was measured by Comet assay immediately after irradiation. DNA repair was detected by analyzing the cells at defined time intervals after the exposure. Furthermore, all subjects were genotyped for XRCC1, OGG1, and XPC genes.
Results: After X-ray irradiation, persons bearing XRCC1 homozygous variant (codon 399) genotype exhibited significantly lower Tail DNA values than those bearing wild-type and heterozygous genotypes. These results are also confirmed at 30 and 60 min after irradiation. Furthermore, XPC heterozygous subjects (variant codon 939) showed lower residual DNA damage 60 min after irradiation compared with wild-type and homozygous genotypes.
Conclusion: The results of the present study show that polymorphisms in DNA repair genes could influence individual DNA repair capacity. (c) 2006 Elsevier Inc
Canine small clear cell/T-zone lymphoma: Clinical presentation and outcome in a retrospective case series
No full textPublished studies, taken together, suggest the existence of a single canine lymphoma entity, with a small clear cell appearance by cytological evaluation, a histopathological T-zone pattern and an aberrant CD45-negative T-cell phenotype, mostly characterized by long-term survival. We describe clinical presentation and outcome in a retrospective case series of canine small clear cell/T-zone lymphoma. Despite the reported predisposition of Golden retriever, this breed was not represented in our case series. Most dogs presented with stage V disease, whereas only few had clinical signs or peripheral cytopenias. Blood was almost always more infiltrated than bone marrow. Median survival confirmed the favourable prognosis described in literature, but a few dogs died within a short time. Also, a subgroup of dogs developed second malignancies, eventually leading to death. We did not investigate possible prognostic factors because of the wide variety in treatments, and further studies are needed to identify high-risk animals
Artt 1737-1741 cc.
No full textLe norme del codice in commento analizzano l'istituto e la disciplina del contratto di spedizione, soffermandosi su una figura atipica utilizzata nella prassi dei trasporti allorchè le parti si avvalgono delle c.g.c. degli spedizionieri internazionali del 1975 e 1992.[...
Handwritten biographical information on Paulina T. McClung Merritt
No full textA handwritten biography of Paulina T. McClung Merritt by an unknown author, 1892.
Heterogeneous and tissue-specific regulation of effector T cell responses by IFN-gamma during Plasmodium berghei ANKA infection.
No full textIFN-γ and T cells are both required for the development of experimental cerebral malaria during Plasmodium berghei ANKA infection. Surprisingly, however, the role of IFN-γ in shaping the effector CD4(+) and CD8(+) T cell response during this infection has not been examined in detail. To address this, we have compared the effector T cell responses in wild-type and IFN-γ(-/-) mice during P. berghei ANKA infection. The expansion of splenic CD4(+) and CD8(+) T cells during P. berghei ANKA infection was unaffected by the absence of IFN-γ, but the contraction phase of the T cell response was significantly attenuated. Splenic T cell activation and effector function were essentially normal in IFN-γ(-/-) mice; however, the migration to, and accumulation of, effector CD4(+) and CD8(+) T cells in the lung, liver, and brain was altered in IFN-γ(-/-) mice. Interestingly, activation and accumulation of T cells in various nonlymphoid organs was differently affected by lack of IFN-γ, suggesting that IFN-γ influences T cell effector function to varying levels in different anatomical locations. Importantly, control of splenic T cell numbers during P. berghei ANKA infection depended on active IFN-γ-dependent environmental signals--leading to T cell apoptosis--rather than upon intrinsic alterations in T cell programming. To our knowledge, this is the first study to fully investigate the role of IFN-γ in modulating T cell function during P. berghei ANKA infection and reveals that IFN-γ is required for efficient contraction of the pool of activated T cells
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