446 research outputs found
INTEL AND AMD CPU COMPARISON
No full textThe author in this work compares Intel and AMD CPU’s in different price categories. Themes which are discussed is CPU history, characteristics and compared Intel and AMD CPU’s. At the end is conclusions about the Intel and AMD CPU’s advantages un disadvantages
Pharmacotherapy for AMD: state-of-the-art
No full text
The article discusses the evolution of the treatment for a socially important disease, age-related macular degeneration (AMD). Data on earlier and recent treatment for “wet” AMD as well as promising trends in the development of novel medications are addressed.
It was established that AMD is one of the most common causes of low vision in people over 50 years in developed countries. An estimated 30 to 50 million patients worldwide suffer from this disease. “Wet” AMD is responsible for 90% of visual impairment or blindness due to AMD. About 500,000 of new “wet” AMD cases are diagnosed every year worldwide. Agents which prevent neovascularization by inhibiting vascular endothelial growth factor (VEGF) are currently used to manage this rapidly progressing type of AMD. It was demonstrated that VEGF inhibiting prevents the development of choroidal neovascular membrane, reduces the sizes of pre-existing membrane, and decreases vascular leakage from new vessels. Ranibizumab and aflibercept (Eylea) are the most well-studied and commonly used agents.
Keywords: age-related macular degeneration, AMD, choroidal neovascular membrane, intravitreal injection, VEGF, ranibizumab, aflibercept, Eylea.
For citation: Koroleva I.A., Gvetadze A.A., Romanova T.B. Pharmacotherapy for AMD: state-of-the-art. Russian Journal of Clinical Ophthalmology. 2019;19(2):105–109.
About the authors:
1Irina A. Koroleva — MD, PhD, ophthalmologist, ORCID iD 0000-0003-1679-5701;
2Anna A. Gvetadze — MD, PhD, ophthalmologist, ORCID iD 0000-0003-4535-2694;
3Tatiana B. Romanova — MD, PhD, Associate Professor of the Department of Ophthalmology, ORCID iD 0000-0002-3865-2691.
1City Clinical Hospital No. 15. 23, Veshnyakovskaya str., Moscow, 111539, Russian Federation.
2LLC “Clinic “Sphere”. 10, Starokachalovskaya str., Moscow, 117628, Russian Federation.
3Pirogov Russian National Research Medical University. 1, Ostrovityanova str., Moscow, 117997, Russian Federation.
Contact information: Irina A. Koroleva, e-mail: [email protected].
Financial Disclosure: no author has a financial or property interest in any material or method mentioned. There is no conflict of interests. Received 14.04.2019.
</p
A Population-Based Ultra-Widefield Digital Image Grading Study for Age-Related Macular Degeneration-Like Lesions at the Peripheral Retina.
No full textOur understanding of the relevance of peripheral retinal abnormalities to disease in general and in age-related macular degeneration (AMD) in particular is limited by the lack of detailed peripheral imaging studies. The purpose of this study was to develop image grading protocols suited to ultra-widefield imaging (UWFI) in an aged population
Evolutionary-based Design and Control of Geometry Aims for AMD-manufacturing of Ti-6Al-4V Parts
No full textAbstractAdditive Metal Deposition (AMD) is an additive manufacturing process building parts based on a nozzle-fed powder by laser assisted solidification. The AMD technology offers unique advantages for the production of near net-shape parts. In contrast to the powder bed-based technologies it provides a high productivity grade.Today AMD lacks reproducible process strategies manufacturing large parts in narrow tolerances. The building height of a single layer and the geometrical shape of a whole part alter progressively with increasing part dimensions - consecutively leading to a higher effort in the manufacturing-process development for such parts.To reduce this effort, in this paper first an iterative identification of optimal process parameters is performed by following an evolutionary algorithm under varied BC. Based on the geometry-related parameter sets, tolerances are defined. The process strategies and tolerances are validated for a prototype application considering the defined quality aims. Finally the results are discussed and summarized in an a-priori process design guideline for AMD Ti6Al4V-parts
Medical Perspective: Macular Degeneration (AMD) and Human Sight in the Future
No full textThe author concisely presents the results of his 30-year investigations about the harmful influence of the higher sun radiation on the eyes. The investigations were carried out among the population of the Island of Rab, situated in the northern part of the Adriatic sea. This geographical region has been characterized by higher doses of the global sun radiation compared with the remining part of the Republic of Croatia, and partly with the rest of the Mediterranean. The author proved it by his own measurements of UV-B, UV-A and the global sun radiation. The number of the diseased from the macular degeneration (AMD), cataract and precancerous pterygium has been significantly increased in those inhabitants being more exposed to the sun radiation. Investigating the retinal threshold,of the macula and peripherally – meridian thresholds, even the children more exposed to the sun radiation without protection, are established to have the increased excitation threshold of the retina, making later the basis and risk factor for the earlier AMD development. The author also points out that the periphery of retina and the macula are damaged in AMD. Later stages of macular degeneration transfer to the clinical form of the optic nerve atrophy. The author pathohistologically proved that the whole retina has been degeneratively involved in AMD, not only the photoreceptors and the retinal pigment. Therefore, the author pleads for the idea of children protection from the higher sun radiation to become a national problem of each country, and the coordination must be with the World Health Organization (WHO)
Raised levels of agalactosyl IgG in childhood tuberculosis
No full textRaised levels of agalactosyl immunoglobulin G (IgG) have been found in adults with tuberculosis, Crohn's disease and rheumatoid arthritis, and recent evidence, both circumstantial and experimental, suggests that it has distinct functional properties that play a role in pathogenesis. Since tuberculosis in infants is strikingly different from the disease seen in adults, but switches to the adult form at adrenarche or puberty, we documented the association of agalactosyl IgG with tuberculosis in childhood between the ages of 0 and 16 years. Sera were collected from 99 children diagnosed as cases of tuberculosis in Istanbul, Turkey, and compared with levels in non-tuberculous controls. The percentage of agalactosyl IgG was significantly raised in children with tuberculosis overall (P<0.001, Mann-Whitney U test) and in all age groups except for children over 12 years old, whose numbers were too small to be meaningful. Therefore the differences between adult and childhood tuberculosis are not due to a difference in the tendency for agalactosyl IgG to be produced at different ages. The percentage of agalactosyl IgG may be useful for monitoring the progress of individual complicated cases
Prediction of age-related macular degeneration in the general population: The three continent AMD consortium
No full textPurpose Prediction models for age-related macular degeneration (AMD) based on case-control studies have a tendency to overestimate risks. The aim of this study is to develop a prediction model for late AMD based on data from population-based studies. Design Three population-based studies: the Rotterdam Study (RS), the Beaver Dam Eye Study (BDES), and the Blue Mountains Eye Study (BMES) from the Three Continent AMD Consortium (3CC). Participants People (n = 10 106) with gradable fundus photographs, genotype data, and follow-up data without late AMD at baseline. Methods Features of AMD were graded on fundus photographs using the 3CC AMD severity scale. Associations with known genetic and environmental AMD risk factors were tested using Cox proportional hazard analysis. In the RS, the prediction of AMD was estimated for multivariate models by area under receiver operating characteristic curves (AUCs). The best model was validated in the BDES and BMES, and associations of variables were re-estimated in the pooled data set. Beta coefficients were used to construct a risk score, and risk of incident late AMD was calculated using Cox proportional hazard analysis. Cumulative incident risks were estimated using Kaplan-Meier product-limit analysis. Main Outcome Measures Incident late AMD determined per visit during a median follow-up period of 11.1 years with a total of 4 to 5 visits. Results Overall, 363 participants developed incident late AMD, 3378 participants developed early AMD, and 6365 participants remained free of any AMD. The highest AUC was achieved with a model including age, sex, 26 single nucleotide polymorphisms in AMD risk genes, smoking, body mass index, and baseline AMD phenotype. The AUC of this model was 0.88 in the RS, 0.85 in the BDES and BMES at validation, and 0.87 in the pooled analysis. Individuals with low-risk scores had a hazard ratio (HR) of 0.02 (95% confidence interval [CI], 0.01-0.04) to develop late AMD, and individuals with high-risk scores had an HR of 22.0 (95% CI, 15.2-31.8). Cumulative risk of incident late AMD ranged from virtually 0 to more than 65% for those with the highest risk scores. Conclusions Our prediction model is robust and distinguishes well between those who will develop late AMD and those who will not. Estimated risks were lower in these population-based studies than in previous case-control studies. Financial Disclosure(s) The author(s) have no proprietary or commercial interest in any materials discussed in this article
Prediction of Age-related Macular Degeneration in the General Population: The Three Continent AMD Consortium
No full textPrediction models for age-related macular degeneration (AMD) based on case-control studies have a tendency to overestimate risks. The aim of this study is to develop a prediction model for late AMD based on data from population-based studies. Three population-based studies: the Rotterdam Study (RS), the Beaver Dam Eye Study (BDES), and the Blue Mountains Eye Study (BMES) from the Three Continent AMD Consortium (3CC). People (n = 10 106) with gradable fundus photographs, genotype data, and follow-up data without late AMD at baseline. Features of AMD were graded on fundus photographs using the 3CC AMD severity scale. Associations with known genetic and environmental AMD risk factors were tested using Cox proportional hazard analysis. In the RS, the prediction of AMD was estimated for multivariate models by area under receiver operating characteristic curves (AUCs). The best model was validated in the BDES and BMES, and associations of variables were re-estimated in the pooled data set. Beta coefficients were used to construct a risk score, and risk of incident late AMD was calculated using Cox proportional hazard analysis. Cumulative incident risks were estimated using Kaplan-Meier product-limit analysis. Incident late AMD determined per visit during a median follow-up period of 11.1 years with a total of 4 to 5 visits. Overall, 363 participants developed incident late AMD, 3378 participants developed early AMD, and 6365 participants remained free of any AMD. The highest AUC was achieved with a model including age, sex, 26 single nucleotide polymorphisms in AMD risk genes, smoking, body mass index, and baseline AMD phenotype. The AUC of this model was 0.88 in the RS, 0.85 in the BDES and BMES at validation, and 0.87 in the pooled analysis. Individuals with low-risk scores had a hazard ratio (HR) of 0.02 (95% confidence interval [CI], 0.01-0.04) to develop late AMD, and individuals with high-risk scores had an HR of 22.0 (95% CI, 15.2-31.8). Cumulative risk of incident late AMD ranged from virtually 0 to more than 65% for those with the highest risk scores. Our prediction model is robust and distinguishes well between those who will develop late AMD and those who will not. Estimated risks were lower in these population-based studies than in previous case-control studies. The author(s) have no proprietary or commercial interest in any materials discussed in this articl
Rekayasa Teknik Merubah Nama Kartu Grafis AMD Radeon Menggunakan Notepad Pada Sistem Operasi Windows 10
No full textNama Kartu grafis merupakan bentuk informasi sebuah perangkat komputer maupun perangkat laptop yang sangat penting saat ini, selain fungsinya sangat di sukai hampir disemua kalangan, perangkat komputer yang satu ini tidak bisa jauh dari pasangannya yaitu sebuah prosesor, tidak ada kartu grafis maka prosesor tidak akan menunjukan fungsinya dengan maksimal. Sebut saja salah satu brand kartu grafis terkenal, yaitu AMD (Advanced Micro Device). Namun penamaan kartu grafis yang diberikan AMD lewat driver masih kurang jelas dan akurat, dikarenakan developer yang mengelola divisi driver AMD ini masih malas merubah nama produk kartu grafisnya satu per satu setiap brand, oleh karena itu maka penulis akan membuat Rekayasa teknik merubah nama kartu grafis AMD Radeon Menggunakan Notepad pada sistem operasi windows 10, sehingga dengan ini user atau pengguna kartu grafis AMD Radeon akan bisa lebih memahami secara mendalam mengapa kartu grafis ini namanya tidak sesuai.
Kata Kunci: Kartu Grafis, AMD Radeon, Notepad
The name of the graphics card is a form of information devices and laptop computers are very important at this time, in addition to its functions very preferred in almost all circles of computer devices, this one could not be further from his partner a processor, no graphics card then the processor will not indicate it functions optimally. Call it one of the brand famous, i.e. graphics card AMD (Advanced Micro Device). But the naming of the given graphics card AMD passing drivers still less clear and accurate, due to the developer who manages the Division drivers AMD is still lazy graphics card product name change one by one each brand, therefore then the author would mak e engineering change name AMD Radeon graphics cardusing Notepad on a windows operating system 10, so with this user or users of the AMD Radeon graphics card will be able to understand more deeply why this graphics card name is not appropriate.
Keywords: Graphics Card, AMD Radeon, Notepad
Nama Kartu grafis merupakan bentuk informasi sebuah perangkat komputer maupun perangkat laptop yang sangat penting saat ini, selain fungsinya sangat di sukai hampir disemua kalangan, perangkat komputer yang satu ini tidak bisa jauh dari pasangannya yaitu sebuah prosesor, tidak ada kartu grafis maka prosesor tidak akan menunjukan fungsinya dengan maksimal. Sebut saja salah satu brand kartu grafis terkenal, yaitu AMD (Advanced Micro Device). Namun penamaan kartu grafis yang diberikan AMD lewat driver masih kurang jelas dan akurat, dikarenakan developer yang mengelola divisi driver AMD ini masih malas merubah nama produk kartu grafisnya satu per satu setiap brand, oleh karena itu maka penulis akan membuat Rekayasa teknik merubah nama kartu grafis AMD Radeon Menggunakan Notepad pada sistem operasi windows 10, sehingga dengan ini user atau pengguna kartu grafis AMD Radeon akan bisa lebih memahami secara mendalam mengapa kartu grafis ini namanya tidak sesuai.
Kata Kunci: Kartu Grafis, AMD Radeon, Notepad
The name of the graphics card is a form of information devices and laptop computers are very important at this time, in addition to its functions very preferred in almost all circles of computer devices, this one could not be further from his partner a processor, no graphics card then the processor will not indicate it functions optimally. Call it one of the brand famous, i.e. graphics card AMD (Advanced Micro Device). But the naming of the given graphics card AMD passing drivers still less clear and accurate, due to the developer who manages the Division drivers AMD is still lazy graphics card product name change one by one each brand, therefore then the author would mak e engineering change name AMD Radeon graphics cardusing Notepad on a windows operating system 10, so with this user or users of the AMD Radeon graphics card will be able to understand more deeply why this graphics card name is not appropriate.
Keywords: Graphics Card, AMD Radeon, Notepad
 
Does Age-Related Macular Degeneration (AMD) Treatment Influence Patient Falls and Mobility? A Systematic Review.
No full textPURPOSE: Age-related macular degeneration (AMD), a leading cause of irreversible blindness, increases fall risk through impaired central vision. Falls place an enormous economic burden on healthcare systems. We hypothesized that AMD treatments may reduce patients\u27 falls risk. This systematic review (ID #: 172623) synthesized the current understanding of wet and dry AMD treatments\u27 impact on patient falls and mobility, connecting these two public health issues.
METHODS: On April 17, 2020, PubMed, Scopus, CINAHL, and the Cochrane Central Register of Controlled Trials were queried. Clinical trials and observational studies were included, while non-English and non-primary studies were excluded. Two authors screened, extracted data, and assessed bias using RoB-2 and ROBINS-I. A third author served as a tie breaker.
RESULTS: This database search resulted in 3,525 studies, with an additional 112 identified through bibliography review. Ten articles met eligibility criteria. Most studies featured the outcome of interest as a secondary outcome (n = 4) and patient-reported adverse events (n = 5), rather than a primary focus (n = 2). Ten out of the 11 outcomes had a moderate to serious risk of bias. No two studies used the same instrument to measure falls or mobility.
CONCLUSION: Despite the potential positive impact of AMD treatments on patient falls and mobility, quality data on this relationship are lacking. This work underscores the need to broaden ophthalmologic research outcomes beyond visual parameters to include patient-centred, functional measures. Incorporating standardized methods to track falls and screen for difficulty with walking and balance would enable evaluation of AMD treatments on functional outcomes, potentially helping guide management
- …
