102,157 research outputs found
Dal liber singularis alla personalità di Paolo: un percorso nel Progetto ‘Scriptores iuris Romani’
No full textUna rapida ricognizione sul percorso svolto entro il Progetto "Scriptores iuris Romani" in merito alla produzione monografica di Giulio Paolo, e uno sguardo sulle future prospettive di ricerc
Divagazioni storiche e non sulla presunta "personalizzazione" delle servitù prediali a seguito di una nota pronuncia costituzionale
No full text
Nuove riflessioni sulla presenza dei libri singulares nella massa 'edittale'
No full textThis article is meant to provide an answer to the following question,
concerning the composition of Justinian’s Digest: why none of Paul’s libri singulares were
conferred to the ‘edictal’ commission? The point is considering if this “absence” is caused
by the special nature of those libri, who could have then been substantially different from
the Ad edictum text (and so, they couldn’t be seen as part of it, that went separated in late
Antiquity). To achieve this goal, there are basically three obstacles to overcome: first, the
division of Paul’s Ad edictum between two masses (‘edictal’ and ‘sabinian’); then, the
depth of philological consciousness and critical judgment expressed by Justinian’s
compilers in their work; lastly, the presence, among the books read by the ‘edictal’
commission, of some libri singulares by other jurists. Getting through these problems is
the only way to acknowledge the possibility of a link between the typology of a book and
its use by Tribonian
L'argumentum e contrario e il problema delle lacune: spunti in merito alla prospettiva dei giuristi romani
No full textTra Tura e Cossa: immagini di stelle
No full textIl saggio analizza per la prima volta i disegni che corredano il manoscritto Vat. Lat. 3099 della Biblioteca Vaticana. L'analisi precisa i modelli delle immagini astrologiche dal punto di vista iconografico e li attribuisce ad artista ferrarese vicino a Francesco del Cossa e agli affreschi del pittore nel Salone di Palazzo Schifanoi
Localized inhibition of protein phosphatase 1 by NUAK1 promotes spliceosome activity and reveals a MYC-sensitive feedback control of transcription
No full textDeregulated expression of MYC induces a dependence on the NUAK1 kinase, but the molecular mechanisms underlying this dependence have not been fully clarified. Here we show that NUAK1 is a predominantly nuclear protein that associates with a network of nuclear protein phosphatase 1 (PP1) interactors and that PNUTS, a nuclear regulatory subunit of PP1, is phosphorylated by NUAK1. Both NUAK1 and PNUTS associate with the splicing machinery. Inhibition of NUAK1 abolishes chromatin association of PNUTS, reduces spliceosome activity and suppresses nascent RNA synthesis. Activation of MYC does not bypass the requirement for NUAK1 for spliceosome activity, but significantly attenuates transcription inhibition. Consequently, NUAK1 inhibition in MYC-transformed cells induces global accumulation of RNAPII both at the pause-site and at the first exon/intron boundary, but does not increase mRNA synthesis. We suggest that NUAK1 inhibition in the presence of deregulated MYC traps non-productive RNAPII due to the absence of correctly assembled spliceosomes
Localized inhibition of protein phosphatase 1 by NUAK1 promotes spliceosome activity and reveals a MYC-sensitive feedback control of transcription
No full textDeregulated expression of MYC induces a dependence on the NUAK1 kinase, but the molecular mechanisms underlying this dependence have not been fully clarified. Here we show that NUAK1 is a predominantly nuclear protein that associates with a network of nuclear protein phosphatase 1 (PP1) interactors and that PNUTS, a nuclear regulatory subunit of PP1, is phosphorylated by NUAK1. Both NUAK1 and PNUTS associate with the splicing machinery. Inhibition of NUAK1 abolishes chromatin association of PNUTS, reduces spliceosome activity and suppresses nascent RNA synthesis. Activation of MYC does not bypass the requirement for NUAK1 for spliceosome activity, but significantly attenuates transcription inhibition. Consequently, NUAK1 inhibition in MYC-transformed cells induces global accumulation of RNAPII both at the pause-site and at the first exon/intron boundary, but does not increase mRNA synthesis. We suggest that NUAK1 inhibition in the presence of deregulated MYC traps non-productive RNAPII due to the absence of correctly assembled spliceosomes
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