1,721,067 research outputs found
Optical Coherence Tomographic Angiography in Diabetic Macular Ischemia A New Step Forward
No full text
New insight on choroidal vasculature: multimodal morphofunctional approach
No full textmaging the choroid in vivo using standard modalities is difficult because of light scattering within overlying tissue, particularly the retinal pigment epithelium (RPE). Although the choriocapillaris is composed of relatively large-diameter capillaries, they are interconnected in a dense arrangement. The flow in the choriocapillaris is fast and because of the prominent fluorescein leakage vascular structure is obscured. Indocyanine green dye shows less leakage than fluorescein, but it still leaks from the choriocapillaris and stains Bruch’s membrane and the choroidal stroma. Optical coherence tomography angiography has high axial resolution, but the lateral resolution is insufficient to visualize the choriocapillaris clearly in the posterior pole. Nevertheless, it can detect choriocapillaris blood flow, producing contrast between the RPE and choriocapillaris. However, because of signal loss, fringe
wash-out, and thresholding used in signal processing, the vessels in Sattler’s layer and certainly in Haller’s layer appear dark in normal eyes. Purpose of the lecture is to evaluate various choroidal multimodal imaging findings and to allocate them in the context of different macular diseases
Type II idiopathic macular telangiectasia and soft confluent drusen
No full textPURPOSE. To describe the simultaneous presentation of soft confluent drusen and type 2 idiopathic macular telangiectasia (IMT) in both eyes of one patient. METHODS. A 79-year-old man with bilateral metamorphopsia and gradual reduction of central vision underwent a complete ophthalmologic examination. RESULTS. In this patient, fundus biomicroscopy revealed soft confluent drusen and a cystic appearance within the fovea, and fluorescein angiography (FA) showed late dye leakage. Interestingly, indocyanine green angiography (ICGA) showed absence of late hypercyanescence, and spectral domain optical coherence tomography (Spectralis SD-OCT) clearly revealed the presence of bilateral foveal cysts with thinning and loss of the normal architecture of the outer retina, as well as absence of retinal thickening within the parafoveolar area showing discrete late dye leakage on FA. Based on these findings, the patient was diagnosed with nonexudative age-related macular degeneration with foveal soft confluent drusen, and coincident nonproliferative type 2 IMT. CONCLUSIONS. To our knowledge, there is no previously reported case of simultaneous presentation of soft confluent drusen and type 2 IMT. This report highlights the importance of ICGA and OCT in the correct diagnosis of such cases. (Eur J Ophthalmol 2010; 20: 466-8
New insight on choroidal vasculature: multimodal morphofunctional approach
No full textmaging the choroid in vivo using standard modalities is difficult because of light scattering within overlying tissue, particularly the retinal pigment epithelium (RPE). Although the choriocapillaris is composed of relatively large-diameter capillaries, they are interconnected in a dense arrangement. The flow in the choriocapillaris is fast and because of the prominent fluorescein leakage vascular structure is obscured. Indocyanine green dye shows less leakage than fluorescein, but it still leaks from the choriocapillaris and stains Bruch’s membrane and the choroidal stroma. Optical coherence tomography angiography has high axial resolution, but the lateral resolution is insufficient to visualize the choriocapillaris clearly in the posterior pole. Nevertheless, it can detect choriocapillaris blood flow, producing contrast between the RPE and choriocapillaris. However, because of signal loss, fringe
wash-out, and thresholding used in signal processing, the vessels in Sattler’s layer and certainly in Haller’s layer appear dark in normal eyes. Purpose of the lecture is to evaluate various choroidal multimodal imaging findings and to allocate them in the context of different macular diseases
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