1,721,667 research outputs found
Thirty years of fatal familial insomnia and autonomic research: celebrating the past, embracing the future
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Circadian rhythms of cardiovascular autonomic function: Physiology and clinical implications in neurodegenerative diseases
No full textCircadian rhythms of blood pressure and heart rate are regulated by a biological clock located in the suprachiasmatic nucleus (SCN) of the hypothalamus, which modulates the autonomic nervous system activity directed to the heart and blood vessels. Humoral mediators released with periodicity induced by the SCN as well as sleep are also important factors. Disruption of physiological cardiovascular circadian rhythms has important clinical implications, as it is associated with increased morbidity and mortality. In this review, firstly we will give an overview on the neuroanatomic and physiologic aspects of cardiovascular circadian rhythms. Secondly we will examine how to assess them in clinical practice. Finally we will discuss certain neurodegenerative diseases in which there is an alteration of these rhythms, such as Parkinson's disease and Alzheimer's disease
Fatal Familial Insomnia: A Rare Disease with Unique Clinico-Neurophysiological Features
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Physiological responses to pain in cancer patients: A systematic review
Full text linkBackground and objective: Pain is one of the most debilitating symptoms in persons with cancer. Still, its assessment is often neglected both by patients and healthcare professionals. There is increasing interest in conducting pain assessment and monitoring via physiological signals that promise to overcome the limitations of state-of-the-art pain assessment tools. This systematic review aims to evaluate existing experimental studies to identify the most promising methods and results for objectively quantifying cancer patients’ pain experience. Methods: Four electronic databases (Pubmed, Compendex, Scopus, Web of Science) were systematically searched for articles published up to October 2020. Results: Fourteen studies (528 participants) were included in the review. The selected studies analyzed seven physiological signals. Blood pressure and ECG were the most used signals. Sixteen physiological parameters showed significant changes in association with pain. The studies were fairly consistent in stating that heart rate, the low-frequency to high-frequency component ratio (LF/HF), and systolic blood pressure positively correlate with the pain. Conclusions: Current evidence supports the hypothesis that physiological signals can help objectively quantify, at least in part, cancer patients’ pain experience. While there is much more to be done to obtain a reliable pain assessment method, this review takes an essential first step by highlighting issues that should be taken into account in future research: use of a wearable device for pervasive recording in a real-world context, implementation of a big-data approach possibly supported by AI, including multiple stratification factors (e.g., cancer site and stage, source of pain, demographic and psychosocial data), and better-defined recording procedures. Improved methods and algorithms could then become valuable add-ons in taking charge of cancer patients
Thirty Years of Multiple System Atrophy (1989–2019): Are We Better at Diagnosing It Than Previously?
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Choosing Wisely: five recommendations related to tests, treatments, and procedures at risk of inappropriateness in the cure of Parkinson’s disease (LIMPE-DISMOV Academy)
Full text linkRoom tilt illusion and persistent hiccups as presenting symptoms of a left PICA stroke: a case report
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