1,721,156 research outputs found
Emerging technology to develop novel red winemaking practices: An overview
Full text linkNowadays, making modifications to traditional practices and/or adopting novel processing technologies is of great interest in order to fulfill consumers expectations towards food products characterized by convenience, variety, adequate shelf-life and caloric content, healthy properties, reasonable cost, and environmental sustainability. In this perspective, the role of emerging technologies in winemaking is addressed towards reduced production time, optimized resources and spaces, extraction of high nutraceutic components through mechanical effects, high energy efficiency, extended shelf-life, lowering SO2 addition and its final concentration. This paper is the outcome of an extensive and comprehensive literature review describing, by an integrated approach, the main characteristics and applications of three emerging technologies (US, MW, and PEF) alternative to the traditional winemaking processes. Their advantages related to the safety aspects of wine, such as the ability to improve nutraceutic and sensorial features are also described. Industrial relevance The food industry is currently interested in a variety of novel production and emerging technologies that may result in economical and quality products. This review shows as numerous researches have strongly demonstrated the great benefits of new emerging technologies, such as PEF, US, and MW, into the oenological industry, either increasing compounds extraction during maceration of the must or accelerating stabilization stage in the wine. Emerging technologies could offer better products to consumers with added value in terms of nutritional or sensorial characteristics, and guarantee higher profit for the industry, even reducing process time and use of natural resources, such as energy, water, and chemicals
Attività antimicrobica di alcuni oli essenziali in associazione con antibiotici antifungini. Ruolo determinante della componente fenolica e terpenolica
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Variazioni strutturali su analoghi della Tocainide a potenziale attività antimiotonica”
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2D- and 3D-QSAR of tocainide and mexiletine analogues acting as Na(v)1.4 channel blockers
No full textEnantiomeric forms of Tocainide, Mexiletine, and structurally related local anaesthetic compounds, were
analyzed with respect to their potency in blocking Nav1.4 channel. Structure–activity relationships based
on in vitro pharmacological assays, suggested that an increase in terms of lipophilicity and/or molecular
surface as well as the presence of specific polar spacers might be determinant for receptor interactions.
QSAR and pharmacophore models were then used to support at 3D level this hypothesisEnantiomeric forms of Tocainide. Mexiletine, and structurally related local anaesthetic compounds, were analyzed with respect to their potency in blocking Na(v)1.4 channel. Structure-activity relationships based on in vitro pharmacological assays, suggested that an increase in terms of lipophilicity and/or molecular surface as well as the presence of specific polar spacers might be determinant for receptor interactions. QSAR and pharmacophore models were then used to support at 3D level this hypothesis. (C) 2008 Elsevier Masson SAS. All rights reserved
Determination of Squalene in Organic Extra Virgin Olive Oils (EVOOs) by UPLC/PDA Using a Single-Step SPE Sample Preparation
Full text linkIn this paper, a simple extraction and fast detection procedure was used to determine squalene (SQ) in extra virgin olive oils (EVOOs). SQ was purified from EVOOs by an efficient single-step solid phase extraction (SPE), and its content was determined using an UPLC-PDA instrument. The adopted technique was evaluated for accuracy, linearity, sensitivity, and repeatability. The precision of the SPE extraction was satisfactory and the mean recoveries were 91.9 ± 0.4 and 96.3 ± 0.3 % for 25 and 50 mg L−1 level of addition, respectively. The selected chromatographic conditions allowed a very fast SQ determination; in fact, it was well separated in ∼0.54 min with good resolution. The UPLC method showed a good linearity in the range 50–500 mg L−1 (R2 = 0.9998). Method sensitivity was evaluated by measuring the limits of detection (LOD) that was 0.3 mg L−1. The method was utilized for SQ determination in 33 different organic EVOO samples, coming from different countries (Turkey, Tunisia, Spain, Portugal, Greece, USA, Slovenia, Albania, Israel, Italy) and the data were statistically evaluated
Organofluorinecontaining anti-infective agents
No full textFluorine atom is a suitable bioisostere in diverse organofluorine compounds acting as anti-infective agents
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