177,611 research outputs found
disegnare con... DINO COPPO
No full textAlcune telefonate e diversi piacevolissimi incontri precedono e affiancano la redazione dell’intervista a Dino Coppo. Ho pensato a questa intervista come a un’occasione per ripercorrere le linee di una ricerca cinquantennale, iniziata negli anni Sessanta del secolo scorso, che ha avuto per oggetto la disciplina del Rilievo urbano. Il racconto inanella una serie di studi, esperienze, incontri, incarichi, a cui fanno da sfondo la valorizzazione dei centri storici e la trasformazione della città postindustriale. Le immagini descrivono la vivacità sperimentale e attenta alle potenzialità dei nuovi strumenti, anche digitali, di una ricerca corale che fa del Disegno il luogo della sintesi interpretativa del reale. La mia partecipazione agli ultimi vent’anni di questo studio fa assumere un particolare significato a un’intervista che diventa a poco a poco dialogo più stretto e arriva a spiegare e dimostrare come gli insegnamenti di questo lungo percorso siano più che mai attuali e possano venire declinati in nuove ricerche e nuovi indirizzi didattici che abbiano per oggetto l’analisi e l’interpretazione del fenomeno urbano.DOI: https://doi.org/10.20365/disegnarecon.26.2021.dw</p
[Audit on quality of life of patients with chronic kidney disease on dialysis and after transplant]
No full textSince the improvement of quality of life (QOL) in patients with chronic disease on dialysis (D-CKD) has been demonstrated to have significant effects on clinical outcome, QOL has been included among the principal targets for these patients. QOL is among the objectives of the Healthy People 2010 program of the United Nations and CKD is one of the 18 focus areas of the program. The process of improving clinical outcome for D-CKD patients is obviously correlated with the continuing attempts to improve the adequacy of dialysis, and this remains a milestone. Some recent studies, including the HEMO study, have demonstrated that the present standards for dialytic efficiency are adequate for morbidity and mortality outcomes. However, these concepts are rapidly evolving and there are emerging factors which should be monitored, such as a) frequency of hospitalization, b) QOL, c) patient's satisfaction, and d) transplantation rate. Each aspect should be taken into consideration when the general well-being of D-CKD patients is at stake. However, there is a lack of validated standards, and there are confounding effects related to different geographical areas, different degrees of morbidity, and different therapies. Health is defined by the WHO as the complete feeling of well-being, and transplantation obviously is a way to overcome the many difficulties encountered by D-CKD patients. It is true that QOL after transplant is affected by uncertainty about the final result, fear of having to go back on dialysis, or anger about unexpected complications. For these reasons special questionnaires have been designed for transplanted patients (e.g., SF-36). These indicate an improvement of QOL for transplanted compared with D-CKD patients, although QOL remains below the level of that of the healthy population. Post-transplant QOL tends to improve over time and will become superimposable to that of the healthy population in the long run. It is of paramount importance that each dialysis and transplantation center provide psychological support not only to patients but also to doctors and nurses
IgACE: a placebo-controlled, randomized trial of angiotensin-converting enzymeinhibitors in children and young people with IgA nephropathy and moderateproteinuria.
No full textJ Am Soc Nephrol. 2007 Jun;18(6):1880-8. Epub 2007 May 18.
IgACE: a placebo-controlled, randomized trial of angiotensin-converting enzyme inhibitors in children and young people with IgA nephropathy and moderate proteinuria.
Coppo R, Peruzzi L, Amore A, Piccoli A, Cochat P, Stone R, Kirschstein M, Linné T.
Source
Nephrology, Dialysis and Transplantation Unit, Regina Margherita University Hospital, 10127 Turin, Italy. [email protected]
Abstract
This European Community Biomedicine and Health Research-supported, multicenter, randomized, placebo-controlled, double-blind trial investigated the effect of an angiotensin-converting enzyme inhibitor (ACE-I) in children and young people with IgA nephropathy (IgAN), moderate proteinuria (>1 and 50 ml/min per 1.73 m(2). Sixty-six patients who were 20.5 yr of age (range 9 to 35 yr), were randomly assigned to Benazepril 0.2 mg/kg per d (ACE-I) or placebo and were followed for a median of 38 mo. The primary outcome was the progression of kidney disease, defined as >30% decrease of CrCl; secondary outcomes were (1) a composite end point of >30% decrease of CrCl or worsening of proteinuria until > or =3.5 g/d per 1.73 m(2) and (2) proteinuria partial remission (6 mo. Analysis was by intention to treat. A single patient (3.1%) in the ACE-I group and five (14.7%) in the placebo group showed a worsening of CrCl >30%. The composite end point of >30% decrease of CrCl or worsening of proteinuria until nephrotic range was reached by one (3.1%) of 32 patients in the ACE-I group, and nine (26.5%) of 34 in the placebo group; the difference was significant (log-rank P = 0.035). A stable, partial remission of proteinuria was observed in 13 (40.6%) of 32 patients in the ACE-I group versus three (8.8%) of 34 in the placebo group (log-rank P = 0.033), with total remission in 12.5% of ACE-I-treated patients and in none in the placebo group (log-rank P = 0.029). The multivariate Cox analysis showed that treatment with ACE-I was the independent predictor of prognosis; no influence on the composite end point was found for gender, age, baseline CrCl, systolic or diastolic BP, mean arterial pressure, or proteinuria
Exploiting inverter-interfaced DG for Voltage unbalance mitigation and ancillary services in distribution systems
No full textThe mucosal immune system and IgA nephropathy
No full textThe precise pathogenesis of immunoglobulin A nephropathy (IgAN) is still not clearly established but emerging evidence confirms a pivotal role for mucosal immunity. This review focuses on the key role of mucosa-associated lymphoid tissue (MALT) in promoting the onset of the disease, underlying the relationship among microbiota, genetic factors, food antigen, infections, and mucosal immune response. Finally, we evaluate potential therapies targeting microbes and mucosa hyperresponsiveness in IgAN patients
Voltage management strategies for low voltage networks supplied through phase-decoupled on-load-tap-changer transformers
No full textSliding time windows assessment of storage systems capability for providing ancillary services to transmission and distribution grids
No full textThe continuous increase of Renewable Energy Sources (RESs) connected to distribution networks requires a careful review of the current regulatory framework to enable the provision of Ancillary Services (ASs) by these small-scale units. One of the envisaged options for coordinating Transmission System Operators (TSOs) and Distribution System Operators (DSOs) is the agreement and regulation of a scheduled power profile at the Primary Substation (PS). This means assigning the balancing responsibility to DSOs and, consequently, reducing the unpredictability of the power exchanges with the upstream transmission grid. The paper proposes a novel procedure for the management of Distributed Energy Storages (DESs) in order to provide ASs to both the DSO (local regulation of distribution network and congestion management) and the TSO (control of the power profile at the PS). The methodology, based on a sliding time window approach, evaluates the actual availability of each storage unit in providing ASs, assigns a scheduled profile and corrects it during the real-time operation. In addition, for each DES, the scheduled State of Charge (SoC) is restored in accordance with network constraints. Simulations on a realistic case study network are carried out considering randomly perturbed power profiles for both loads and generators. Benefits associated with storage coordination (power exchange management at the PS and support to DSO in voltage regulation and congestion resolution) are evaluated and discussed
Risk of MV distribution systems uncontrolled islanding supplied by LV embedded generators
No full text- …
