177,440 research outputs found

    “Pisa rurale”. Intorno alla decorazione dell’Aula Magna della Facoltà di Agraria

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    Partendo dalla decorazione dell'Aula Magna della Facoltà di Agraria dell'Università di Pisa, il contributo affronta il rapporto tra la cultura e la politica agraria del primo '900 e le arti figurativ

    32, Artista mantegnesco del tardo Quattrocento, Venerabile Maddalena Coppini

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    Si descrive il dipinto raffigurante la venerabile Coppini ora conservato presso il Museo della Città in Palazzo San Sebastiano. La tela, di anonimo mantegnesco della fine del Quattrocento, venne probabilmente commissionata dall'arte della lanae, al di sotto della figura della venerabile, presenta alcune storie della vita con un'iscrizione qui letta ed integrata

    Introduzione

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    Acute Hypoglycemia Decreases Myocardial Blood Flow Reserve in Patients With Type 1 Diabetes Mellitus and in Healthy Humans

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    Background-: Hypoglycemia is associated with increased cardiovascular mortality, but the reason for this association is poorly understood. We tested the hypothesis that the myocardial blood flow reserve (MBFR) is decreased during hypoglycemia using myocardial contrast echocardiography in patients with type 1 diabetes mellitus (DM) and in healthy control subjects. Methods and Results-: Twenty-eight volunteers with DM and 19 control subjects underwent hyperinsulinemic clamps with maintained sequential hyperinsulinemic euglycemia (plasma glucose, 90 mg/dL [5.0 mmol/L]) followed by hyperinsulinemic hypoglycemia (plasma glucose, 50 mg/dL [2.8 mmol/L]) for 60 minutes each. Low-power real-time myocardial contrast echocardiography was performed with flash impulse imaging using low-dose dipyridamole stress at baseline and during hyperinsulinemic euglycemia and hyperinsulinemic hypoglycemia. In control subjects, MBFR increased during hyperinsulinemic euglycemia by 0.57 U (22%) above baseline (B coefficient, 0.57; 95% confidence interval, 0.38 to 0.75; P<0.0001) and decreased during hyperinsulinemic hypoglycemia by 0.36 U (14%) below baseline values (B coefficient,-0.36; 95% confidence interval,-0.50 to-0.23; P<0.0001). Although MBFR was lower in patients with DM at baseline by 0.37 U (14%; B coefficient,-0.37; 95% confidence interval,-0.55 to-0.19; P=0.0002) compared with control subjects at baseline, the subsequent changes in MBFR during hyperinsulinemic euglycemia and hyperinsulinemic hypoglycemia in DM patients were similar to that observed in control subjects. Finally, the presence of microvascular complications in the patients with DM was associated with a reduction in MBFR of 0.52 U (24%; B coefficient,-0.52; 95% confidence interval,-0.70 to-0.34; P<0.0001). Conclusions-: Hypoglycemia decreases MBFR in both healthy humans and patients with DM. This finding may explain the association between hypoglycemia and increased cardiovascular mortality in susceptible individuals. © 2011 American Heart Association. All rights reserved

    Gli studi di scienze politiche nella storia post-unitaria dell'Università di Pisa

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    Il saggio ricostruisce il processo di formazione della Facoltà di Scienze politiche dell’Ateneo pisano attraverso la messa a fuoco della costituzione disciplinare, delle linee di ricerca e del contributo dei docenti che ne hanno illustrato la storia
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