1,721,150 research outputs found
Cooper, Keith George, VX18349
No full textThis record was harvested from a previous catalogue system and will be withdrawn in 2025. Information in this record may be superseded or incomplete. Visit this record in UMA's new catalogue at: https://archives.library.unimelb.edu.au/nodes/view/378715Surname: COOPER
Given Name(s) or Initials: KEITH GEORGE
Military Service Number or Last Known Location: VX18349
Missing, Wounded and Prisoner of War Enquiry Card Index Number: 18564192528
Item: [2016.0049.11009] "Cooper, Keith George, VX18349
A comparative study of modelling approaches for the evaluation of healthcare interventions with reference to coronary heart disease
No full textEThOS - Electronic Theses Online ServiceGBUnited Kingdo
An economic evaluation of school-based skills building behavioural interventions of preventing sexually transmitted infections in young people
No full textEnfortumab vedotin with pembrolizumab for first-line treatment of unresectable or metastatic urothelial cancer who are eligible for platinum-containing chemotherapy [ID6332]: a single technology appraisal
No full textThis report is a critique of the company’s submission (CS) to NICE from Astellas Pharma Ltd on the clinical effectiveness and cost effectiveness of enfortumab vedotin with pembrolizumab for the first-line treatment of adult patients with unresectable or metastatic urothelial cancer who are eligible for platinum-containing chemotherapy. It identifies the strengths and weaknesses of the CS
Towards an integrated approach to marine benthic monitoring
No full textIn the UK, most marine benthic monitoring is carried out in a piecemeal fashion, funded by different sectors of industry that utilise the marine environment under licence. Monitoring requirements are imposed by licence conditions, which can vary considerably between licences. The UK Government also conducts marine environmental surveys in support of its legislative commitments. The present investigation reviews these different monitoring approaches to highlight whether synergies between them could be developed into an integrated approach to marine benthic monitoring. An integrated approach would have ecological benefits, as greater consistency in sampling and analytical protocols would reduce uncertainty in the predictions of impact, and facilitate the assessment of Good Environmental Status under the Marine Strategy Framework Directive. The same approach would also be of financial benefit, as spatio-temporal duplication in sampling would be reduced, and the value of acquired data would be maximised, resulting in a more efficient and cost-effective approach
Polatuzumab vedotin in combination for untreated diffuse large B-cell lymphoma: a single technology appraisal
No full textThis report is a critique of the company’s submission (CS) to NICE from Roche on the clinical effectiveness and cost effectiveness of polatuzumab [POLIVY®] for treating adult patients with previously untreated diffuse large B-cell lymphoma (DLBCL). It identifies the strengths and weaknesses of the CS
The cost-effectiveness of second-eye cataract surgery in UK
No full textBackground: elective cataract surgery is the most commonly performed surgical procedure in developed countries. However, it is unclear whether cataract surgery on the second eye provides enough incremental benefit to be considered cost-effective. This study conducted a cost-effectiveness analysis of second-eye cataract surgery in the UK.Design: a cost-effectiveness analysis.Methods: a decision-analytical model was developed to estimate the cost-effectiveness of second-eye cataract surgery, based on a comprehensive epidemiological and economic review to develop the parameters for the model. The model followed the clinical pathway of cohorts of patients receiving second-eye cataract surgery and included costs and health benefits associated with post-surgical complications.Results: in the model, second-eye surgery generated 0.68 additional quality-adjusted life years (QALY) with an incremental cost-effectiveness ratio of £1,964 per QALY gained. In sensitivity analyses, model results were most sensitive to changes in the health-related quality of life (HRQoL) gain associated with second-eye surgery, but otherwise robust to changes in parameter values. The probability that second-eye surgery is cost-effective at willingness to pay thresholds of £10,000 and £20,000 was 100%.Conclusion: second-eye cataract surgery is generally cost-effective based on the best available data and under most assumptions. However, there are only a small number of clinical trials for second-eye cataract surgery, and these have not been conducted in recent years
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