1,557 research outputs found
Does admission grip strength predict length of stay in hospitalised older patients?
No full textEpidemiological studies have shown that grip strength measured in middle-aged and older people is a powerful predictor of functional decline, disability and mortality [1–3]. Findings from cross-sectional data also suggest that grip strength may be a useful single marker of frailty [4]. However, grip strength is rarely measured in a clinical setting either for objective assessment of muscle function in relation to physical function or to predict outcome. The few clinical studies involving measurement of grip strength have been confined to a surgical setting and showed that lower grip strength was associated with increased post-operative complications [5–10]. Two studies also showed a relationship between pre-operative grip strength and post-operative length of sta
Book review: Schuppert, G.F. 2010, Staat als Prozess. Eine staatstheoretische Skizze in sieben Aufzügen
No full textG.F. Schuppert contends the state is the central point of reference in social and political science as well as in legal and economic studies. In devoting the central issue of this book to the state, the author makes it not only a work of central interest for the mentioned disciplines but also opens up the subject for a broad audience
SCHUPPERT, G.F. 2010, Staat als Prozess. Eine staatstheoretische Skizze in sieben Aufzügen Campus, Frankfurt. 190 pp.
No full textG.F. Schuppert contends the state is the central point of reference in social and political science as well as in legal and economic studies. In devoting the central issue of this book to the state, the author makes it not only a work of central interest for the mentioned disciplines but also opens up the subject for a broad audience
Skeletal muscle morphology in sarcopenia defined using the EWGSOP criteria: findings from the Hertfordshire Sarcopenia Study (HSS).
No full textBACKGROUND: Sarcopenia is defined as the loss of muscle mass and function with age and is associated with decline in mobility, frailty, falls and mortality. There is considerable interest in understanding the underlying mechanisms. Our aim was to characterise muscle morphology changes associated with sarcopenia among community dwelling older men.METHODS: One hundred and five men aged 68-76 years were recruited to the Hertfordshire Sarcopenia Study (HSS) for detailed characterisation of muscle including measures of muscle mass, strength and function. Muscle tissue was obtained from a biopsy of the vastus lateralis for 99 men and was processed for immunohistochemical studies to determine myofibre distribution and area, capillarisation and satellite cell (SC) density.RESULTS: Six (6 %) men had sarcopenia as defined by the European Working Group on Sarcopenia in Older People (EWGSOP) criteria. These men had lower SC density (1.7 cells/mm(2) vs 3.8 cells/mm(2), p?=?0.06) and lower SC/fibre ratio (0.02 vs 0.06, p?=?0.06) than men without sarcopenia. Although men with sarcopenia tended to have smaller myofibres and lower capillary to fibre ratio, these relationships were not statistically significant.CONCLUSION: We have shown that there may be altered muscle morphology parameters in older men with sarcopenia. These results have the potential to help identify cell and molecular targets for therapeutic intervention. This work now requires extension to larger studies which also include women
“I Began Understand Piłsudski, When I Reached His Age”. Memoirs of G.F. Matveev in the Form of Interview
No full textGennady Filippovich Matveev (born in 1943), Doctor of Historical Sciences, Honored Professor of Moscow University, Head of the Department of the History of the Southern and Western Slavs of Moscow State University, one of the leading domestic specialists in the modern history of Poland, tells about his life and professional activities at the request of the editors of the journal Slavic World in the Third Millennium. Born on the banks of the Volga, G.F. Matveev spent his childhood and youth in Western Ukraine. Since 1966, his whole life has been inextricably linked with the Moscow University, where he received a diploma in history, completed his postgraduate studies, defended his candidate's and doctoral theses, and where he has been teaching for half a century and was head of the department for more than three decades. The students of G.F. Matveev completed and defended a large number of diplomas, master's and candidate's theses, they work in different cities of the country and abroad. As a historian, G.F. Matveev invariably relies on deep researches in archives, introduces a lot of new material into circulation, his innovative research on the history of the Soviet-Polish war of 1920 caused fruitful discussions both in Russia and in Poland, prompting other historians to further research. Gennady Filippovich is the author of the first fundamental biography in Russian of the key statesman of Poland of the 20th century Józef Piƚsudski. Not limited to the problems of Polish history, G.F. Matveev turned to comparative historical research on the material of various Slavic countries, in particular, on the ideology of peasant movements in the period between the two world wars. As an author and editor, he took part in the work on textbooks on the history of the southern and western Slavs. For more than half a century, G.F. Matveev maintains close ties with the Institute of Slavic Studies of the Russian Academy of Sciences, he is a member of the editorial boards of historical journals, both Russian and Polish.
G.F. Matveev talks about his post-war childhood, youth, impressions of his student years, about his work at the Moscow University, about his numerous trips to Poland and more than half a century of communication with Polish colleagues. He also shares his opinion on the current development and prospects of Polish studies in Russia, the possibilities for further dialogue between the two cultures
Developmental aspects of a life course approach to healthy ageing
No full textexamine the mechanistic basis and wider implications of adopting a developmental perspective on human ageing. Previous models of ageing have concentrated on its genetic basis, or the detrimental effects of accumulated damage, but also have raised issues about whether ageing can be viewed as adaptive itself, or is a consequence of other adaptive processes, for example if maintenance and repair processes in the period up to reproduction are traded off against later decline in function. A life course model places ageing in the context of the attainment of peak capacity for a body system, starting in early development when plasticity permits changes in structure and function induced by a range of environmental stimuli, followed by a period of decline, the rate of which depends on the peak attained as well as the later life conditions. Such path dependency in the rate of ageing may offer new insights into its modification. Focusing on musculoskeletal and cardiovascular function, we discuss this model and the possible underlying mechanisms, including endothelial function, oxidative stress, stem cells and nutritional factors such as vitamin D status. Epigenetic changes induced during developmental plasticity, and immune function may provide a common mechanistic process underlying a life course model of ageing. The life course trajectory differs in high and low resource settings. New insights into the developmental components of the life course model of ageing may lead to the design of biomarkers of later chronic disease risk and to new interventions to promote healthy ageing, with important implications for public health
Peoples of the Middle Volga Region in the writing and archival materials of G.F. Miller
No full textFor the first time in regional historiography, the author carried out a comprehensive historiographic analysis of information on ethnography, linguistics, religious studies, regional history, sociopolitical and sociocultural life of the Finno-Ugric and Turkic peoples of the Middle Volga contained in the works of the outstanding German, historian, geograph and ethnograph G.F. Miller. Value of the submitted material is comprised in the research of the collected by the scientist of copies of unique historical documents, manuscripts of his unpublished works, numerous notes and other valuable materials. The relevance of the subject is predetermined by the development of a perspective trend of historical research development of the problem of relationship between the government and society on the example of the development of the regions of Russia in the XVIII century in the works by G.F. Miller. This study is based on the principles of historicism and multi-factor nature of the historical process, realized through the use of historical-genetic, historical-comparative, historical-biographical, dialectic and typological methods of research. The author concluded that the writings of the scientist allowed not only to carry out detailed description of spiritual and material life of the representatives of Turkic and Finno-Ugric peoples of the Middle Volga Region, to define their ethnoconfessional characteristics, but also to take into account historical, geographical and geopolitical conditions influencing their development and integration into sociocultural, sociopolitical and social and economic space of the Russian Empire. Scientific heritage of G.F. Miller also contributed to the creation of the system of methodological bases of archiving and source study. Potential of this heritage for carrying out different researches is high, partly owing to the handwritten archive of the historian in German in the funds of the Russian State Archive of Ancient Acts, containing extensive cohort of unique historical documents, not introduced into scientific discourse
Decision-Making in Early Internationalization: A Structured Expert Judgement Approach
No full textThe aim of this chapter is to show how a structured approach to elicit expert judgement (SEJ) can guide the practice of early internationalization. We applied SEJ to forecast some critical issues upon which an innovative start-up wished to base their decision of whether to expand their initial operations in Poland and Czech Republic to Brazil. Sixteen participants of an Executive MBA program acted as experts and underwent the procedure for eliciting their judgements. The performance of experts was quantified in terms of statistical accuracy and informativeness, which were combined to provide a performance-based weight for each expert according to Classical Model. The combination of weighted expert judgements led to improved statistical accuracy and informativeness of the forecast. The procedure demonstrates how entrepreneurs can take advantage of expert knowledge in deciding about risky endeavours when lacking their own experiences and reliable data that can guide their choices.Accepted author manuscriptApplied Probabilit
The Queen Elizabeth Hospital Library Annual Report 1968-1975
No full textThe Queen Elizabeth Hospital Library Annual Report for 1964-1965, 1965-1966, 1966-1967, 1967-1968, 1968-1969, 1969-1970, 1971-1972, 1972-1973, 1973-1974, 1974-1975
Letters to DR G.F Donald, 1964
Letter from D.N. Cooper, Librarian-in-Charge, Government Department Libraries to Mrs B. Miskelly 27-6-197
An In-Depth Perspective on the Classical Model
No full textThe Classical Model (CM) or Cooke’s method for performing Structured Expert Judgement (SEJ) is the best-known method that promotes expert performance evaluation when aggregating experts’ assessments of uncertain quantities. Assessing experts’ performance in quantifying uncertainty involves two scores in CM, the calibration score (or statistical accuracy) and the information score. The two scores combine into overall scores, which, in turn, yield weights for a performance-based aggregation of experts’ opinions. The method is fairly demanding, and therefore carrying out a SEJ elicitation with CM requires careful consideration. This chapter aims to address the methodological and practical aspects of CM into a comprehensive overview of the CM elicitation process. It complements the chapter “Elicitation in the Classical Model” in the book Elicitation (Quigley et al. 2018). Nonetheless, we regard this chapter as a stand-alone material, hence some concepts and definitions will be repeated, for the sake of completeness.Applied Probabilit
- …
