2,702 research outputs found
Bovine colostrum and immune function after exercise
No full textStrenuous and/or prolonged exercise causes transient perturbations in immune function. It is well accepted that this is one mechanism contributing to the higher occurrence of infection (e.g. upper respiratory tract infection (URTI)) in athletes, especially endurance athletes. URTI or upper respiratory tract (URT) symptoms can negatively affect training and competition performance but athletes must train intensively to be successful. Therefore, interventions that can legitimately enhance immune function and reduce URTI risk can be of benefit to athletes. Bovine colostrum supplementation has been investigated as a possible nutritional countermeasure to enhance (or maintain) immune function, and reduce URTI risk, following strenuous or prolonged exercise and during intensive training periods. There is convincing evidence that daily supplementation with bovine colostrum, for a number of weeks (and preliminary evidence for acute effects after a single dose), can maintain intestinal barrier integrity, immune function and reduce the chances of suffering URTI or URT symptoms in athletes or those undertaking heavy training. The mechanisms are not fully understood at present but there is preliminary evidence suggesting that the effects on immune function are attributable, at least in part, to small bioactive components that survive digestion and are biologically available after consumption, but further work is required. In summary, the balance of existing evidence does support the notion that bovine colostrum is beneficial for certain groups of athletes, such as those involved in strenuous training (e.g. endurance athletes), in terms of immunity and resistance to infection
Chosen logistics processes in Škoda JS
No full textThis master thesis deals with the purchase and sale process in Škoda JS company. The aim of this work is to assess whether the setting of the purchase and sale process is met by the company also within a real business case, in compliance with set controls, and whether the degree of perfect delivery is sufficient. In the introduction, the author specifies the basic terms: logistics, logistic chain, customer benefits, information systems in logistics, buying and selling. The following chapter introduces Škoda JS company, including the sphere of its entrepreneurial activity. This chapter also deals with the nuclear power industry. In the crucial chapter, the author describes the process of purchase and sale in Škoda JS company and compares it with a real business case. In conclusion, the author evaluates discrepancies and suggests recommendations to avoid them
Similar Morphological and Functional Training Adaptations Occur Between Continuous and Intermittent Blood Flow Restriction
No full textDavids, CJ, Raastad, T, James, L, Gajanand, T, Smith, E, Connick, M, McGorm, H, Keating, S, Coombes, JS, Peake, JM, and Roberts, LA. Similar morphological and functional training adaptations occur between continuous and intermittent blood flow restriction. J Strength Cond Res 35(7): 1784–1793, 2021—The aim of the study was to compare skeletal muscle morphological and functional outcomes after low-load resistance training using 2 differing blood flow restriction (BFR) protocols. Recreationally active men and women (n = 42 [f = 21], 24.4 ± 4.4 years) completed 21 sessions over 7 weeks of load-matched and volume-matched low-load resistance training (30% 1 repetition maximum [1RM]) with either (a) no BFR (CON), (b) continuous BFR (BFR-C, 60% arterial occlusion pressure [AOP]), or (c) intermittent BFR (BFR-I, 60% AOP). Muscle mass was assessed using peripheral quantitative computed tomography before and after training. Muscular strength, endurance, and power were determined before and after training by assessing isokinetic dynamometry, 1RM, and jump performance. Ratings of pain and effort were taken in the first and final training session. An alpha level of p < 0.05 was used to determine significance. There were no between-group differences for any of the morphological or functional variables. The muscle cross sectional area (CSA) increased pre-post training (p = 0.009; CON: 1.6%, BFR-C: 1.1%, BFR-I: 2.2%). Maximal isometric strength increased pre-post training (p < 0.001; CON: 9.6%, BFR-C: 14.3%, BFR-I: 19.3%). Total work performed during an isokinetic endurance task increased pre-post training (p < 0.001, CON: 3.6%, BFR-C: 9.6%, BFR-I: 11.3%). Perceptions of pain (p = 0.026) and effort (p = 0.033) during exercise were higher with BFR-C; however, these reduced with training (p = 0.005–0.034). Overall, these data suggest that when 30% 1RM loads are used with a frequency of 3 times per week, the addition of BFR does not confer superior morphological or functional adaptations in recreationally active individuals. Furthermore, the additional metabolic stress that is proposed to occur with a continuous BFR protocol does not seem to translate into proportionally greater training adaptations. The current findings promote the use of both intermittent BFR and low-load resistance training without BFR as suitable alternative training methods to continuous BFR. These approaches may be practically applicable for those less tolerable to pain and discomfort associated with ischemia during exercise.Full Tex
Not a Painless Condition: Rheumatological and Musculoskeletal Symptoms in Type 2 Diabetes, and the Implications for Exercise Participation
No full textObjectives: People with type 2 diabetes (T2D) are more likely to develop a range of rheumatological and musculoskeletal symptoms (RMS), and experience both chronic and widespread pain, compared with the general population. However, these symptoms are not commonly acknowledged by researchers, which hampers our understanding of the impact on this population. Since exercise is a key lifestyle management strategy for T2D and participation levels are typically low, understanding the potential impact of RMS on exercise participation is critical. The aim of this review is to summarise the literature regarding the prevalence and pathophysiology of RMS in T2D, the evidence for the benefits and risks associated with exercise on RMS, and the currently available tools for the reporting of RMS in both research studies and community settings.Full Tex
Comparison of Javascript ES6 and its React JS library from the point of view of a beginning developer
No full textThis bachelor thesis deals with the issue of Vanilla JavaScript and its React JS library from the perspective of a beginning developer. The aim of the work is to map in detail, practically demonstrate and then compare the basic principles of selected tools Vanilla JavaScript and React JS. The work consists of three imaginary parts. After defining important terms, the author deals in the first part with the Vanilla JavaScript approach. The given part of the procedure presents important principles of pure JavaScript with the end of the part, which is an example of practical development in this tool. The second part of the work deals with the React JS library in the same way. The given part of the work goes again from the description of theoretical principles to a practical demonstration of the development of a functionally identical application, but this time from the point of view of the React JS tool. In the third and final part of the work, the author theoretically compares the key differences, advantages and disadvantages of the principles in the development of the application in Vanilla JavaScript and the React JS library. This part is then concluded with a final summary of the comparison with a detailed description of the advantages and disadvantages of each approach with a framework recommendation for the use of the solutions in various development situations. After reading the work, the reader should get a comprehensive idea of the possibilities of using the tools in solving specific problems, in such a way that they can choose the right tool in practice to solve the problem.Táto bakalárska práca sa zaoberá problematikou Vanilla JavaScriptu a jeho knižnice React JS z pohľadu začínajúceho vývojára. Cieľom práce je detailne zmapovať, prakticky demonštrovať a následne porovnať základné princípy vybraných nástrojov Vanilla JavaScript a React JS. Práca sa skladá z troch pomyselných častí. Po vymedzení dôležitých pojmov sa autor v prvej časti venuje prístupu Vanilla JavaScriptu. Daná časť postupe predstavuje dôležité princípy čistého JavaScriptu so zakončením časti, ktorá tvorí ukážka praktického vývoja v tomto nástroji. Druhá časť práce sa rovnakým spôsobom venuje knižnici React JS. Daná časť práce prechádza opäť od popisu teoretických princípov až po praktickú ukážku vývoja funkcionálne rovnakej aplikácie, tentokrát však z pohľadu nástroja React JS. V tretej a zároveň záverečnej časti práce autor teoreticky porovnáva kľúčové rozdiely, výhody a nevýhody daných princípov pri vývoji aplikácie vo Vanilla JavaScripte a knižnici React JS. Táto časť je následne ukončená záverečným zhrnutím porovnania s detailným popisom výhod a nevýhod jednotlivých prístupov s rámcovým odporúčaním použitia daných riešení v rôznych situáciách vývoja. Po prečítaní danej práce by mal čitateľ získať komplexnú predstavu o možnostiach využitia daných nástrojov pri riešení konkrétnych problémov, takým spôsobom, aby si pri riešení problému v praxi vedel vybrať ten správny nástroj.Tato bakalářská práce se zabývá problematikou Vanilla JavaScriptu a jeho knihovny React JS z pohledu začínajícího vývojáře. Cílem práce je detailně zmapovat, prakticky demonstrovat a následně porovnat základní principy vybraných nástrojů Vanilla JavaScript a React JS. Práce se skládá ze tří pomyslných částí. Po vymezení důležitých pojmů se autor v první části věnuje přístupu Vanilla JavaScriptu. Daná část postupu představuje důležité principy čistého JavaScriptu se zakončením části, která tvoří ukázka praktického vývoje v tomto nástroji. Druhá část práce se stejným způsobem věnuje knihovně React JS. Daná část práce přechází opět od popisu teoretických principů až po praktickou ukázku vývoje funkcionální stejné aplikace, tentokrát však z pohledu funkce React JS. Ve třetí a zároveň závěrečné části práce autor teoreticky porovnává klíčové rozdíly, výhody a nevýhody daných principů při vývoji aplikace ve Vanilla JavaScriptu a knihovně React JS. Tato část je následně ukončena závěrečným shrnutím srovnání s detailním popisem výhod a nevýhod jednotlivých přístupů s rámcovým doporučením použití daných řešení v různých situacích vývoje. Po přečtení dané práce by měl čtenář získat komplexní představu o možnostech využití daných nástrojů při řešení konkrétních problémů, takovým způsobem, aby si při řešení problému v praxi věděl vybrat ten správný nástroj
Oxidative stress is associated with decreased heart rate variability in patients with chronic kidney disease
No full textObjectives: Elevated oxidative stress and reduced heart rate variability (HRV) is prevalent in patients with chronic kidney disease (CKD) and is associated with increased morbidity and mortality. Previous studies have identified a positive association between elevated oxidative stress and autonomic dysfunction, however this relationship has not yet been investigated in the CKD population. Methods: Plasma was collected from 78 patients with stage 3–4 CKD (estimated glomerular filtration rate 25–60 ml/min/1.73 m2) for the assessment of oxidative stress, including plasma total F2-isoprostanes, glutathione peroxidase activity and total antioxidant capacity. Time and frequency HRV parameters were measured from a three lead electrocardiogram. Results: Participants with elevated F2-isoprostanes had reduced HRV compared to patients with normal levels of F2-isoprostanes. A number of HRV parameters were found to be inversely correlated with F2-isoprostanes in all CKD patients, including SDNN (r = −0.337; P < 0.01), VLF (r = −0.281, P = 0.01), LF (r = −0.315, P < 0.01) and total power (r = −0.288, P = 0.01). Multiple linear regression found F2-isoprostanes to be an independent predictor of SDNN (r2 = 0.287, β = −0.272, P = 0.01). Discussion: Oxidative stress is significantly and independently associated with HRV in patients with CKD. Identifying oxidative stress in the pathogenesis of autonomic dysfunction may help target therapeutic strategies.No Full Tex
Comparison of Javascript ES6 and its React JS library from the point of view of a beginning developer
No full textThis bachelor thesis deals with the issue of Vanilla JavaScript and its React JS library from the perspective of a beginning developer. The aim of the work is to map in detail, practically demonstrate and then compare the basic principles of selected tools Vanilla JavaScript and React JS. The work consists of three imaginary parts. After defining important terms, the author deals in the first part with the Vanilla JavaScript approach. The given part of the procedure presents important principles of pure JavaScript with the end of the part, which is an example of practical development in this tool. The second part of the work deals with the React JS library in the same way. The given part of the work goes again from the description of theoretical principles to a practical demonstration of the development of a functionally identical application, but this time from the point of view of the React JS tool. In the third and final part of the work, the author theoretically compares the key differences, advantages and disadvantages of the principles in the development of the application in Vanilla JavaScript and the React JS library. This part is then concluded with a final summary of the comparison with a detailed description of the advantages and disadvantages of each approach with a framework recommendation for the use of the solutions in various development situations. After reading the work, the reader should get a comprehensive idea of the possibilities of using the tools in solving specific problems, in such a way that they can choose the right tool in practice to solve the problem.Táto bakalárska práca sa zaoberá problematikou Vanilla JavaScriptu a jeho knižnice React JS z pohľadu začínajúceho vývojára. Cieľom práce je detailne zmapovať, prakticky demonštrovať a následne porovnať základné princípy vybraných nástrojov Vanilla JavaScript a React JS. Práca sa skladá z troch pomyselných častí. Po vymedzení dôležitých pojmov sa autor v prvej časti venuje prístupu Vanilla JavaScriptu. Daná časť postupe predstavuje dôležité princípy čistého JavaScriptu so zakončením časti, ktorá tvorí ukážka praktického vývoja v tomto nástroji. Druhá časť práce sa rovnakým spôsobom venuje knižnici React JS. Daná časť práce prechádza opäť od popisu teoretických princípov až po praktickú ukážku vývoja funkcionálne rovnakej aplikácie, tentokrát však z pohľadu nástroja React JS. V tretej a zároveň záverečnej časti práce autor teoreticky porovnáva kľúčové rozdiely, výhody a nevýhody daných princípov pri vývoji aplikácie vo Vanilla JavaScripte a knižnici React JS. Táto časť je následne ukončená záverečným zhrnutím porovnania s detailným popisom výhod a nevýhod jednotlivých prístupov s rámcovým odporúčaním použitia daných riešení v rôznych situáciách vývoja. Po prečítaní danej práce by mal čitateľ získať komplexnú predstavu o možnostiach využitia daných nástrojov pri riešení konkrétnych problémov, takým spôsobom, aby si pri riešení problému v praxi vedel vybrať ten správny nástroj.Tato bakalářská práce se zabývá problematikou Vanilla JavaScriptu a jeho knihovny React JS z pohledu začínajícího vývojáře. Cílem práce je detailně zmapovat, prakticky demonstrovat a následně porovnat základní principy vybraných nástrojů Vanilla JavaScript a React JS. Práce se skládá ze tří pomyslných částí. Po vymezení důležitých pojmů se autor v první části věnuje přístupu Vanilla JavaScriptu. Daná část postupu představuje důležité principy čistého JavaScriptu se zakončením části, která tvoří ukázka praktického vývoje v tomto nástroji. Druhá část práce se stejným způsobem věnuje knihovně React JS. Daná část práce přechází opět od popisu teoretických principů až po praktickou ukázku vývoje funkcionální stejné aplikace, tentokrát však z pohledu funkce React JS. Ve třetí a zároveň závěrečné části práce autor teoreticky porovnává klíčové rozdíly, výhody a nevýhody daných principů při vývoji aplikace ve Vanilla JavaScriptu a knihovně React JS. Tato část je následně ukončena závěrečným shrnutím srovnání s detailním popisem výhod a nevýhod jednotlivých přístupů s rámcovým doporučením použití daných řešení v různých situacích vývoje. Po přečtení dané práce by měl čtenář získat komplexní představu o možnostech využití daných nástrojů při řešení konkrétních problémů, takovým způsobem, aby si při řešení problému v praxi věděl vybrat ten správný nástroj
3D pgRouting and visualization in Cesium JS using the integrated model of LADM and IndoorGML
No full textA web-based application has been developed, exploiting the integrated model of LADM andIndoorGML to provide indoor navigation based on the user's access rights in an educationalbuilding. Different types of users (students, teachers, visitors, etc.) have different access rights,which also depend on the exact time (e.g. inside or outside office hours). A 3D BIM IFC fileof a building has been geo-referenced and converted into a LADM complaint database inPostgreSQL/PostGIS and is enriched with information about access rights based on therelationship between users, time and indoor spaces. The PostgreSQL extension pgRouting hasbeen used for the actual routing. To support the access rights-based routing, the databasecontains several tables to represent nodes, edges, parties (users), and rights. There is one overallnetwork for the whole building, and database views are used to dynamically select the relevantnodes and edges based on the time and the user’s rights. The Dijkstra algorithm is used tocompute the shortest path. Finally, the 3D geospatial web-platform Cesium JS is used to createa client GUI allowing to specify start and destination, the user and time, and to visualize thenavigation routes. As this GUI is web-based it can run on different platforms, such as desktops,laptops, tablets and mobile phones. This paper provides a complete description of all the stepsto design, develop and test the integrated model of LADM and IndoorGML.GIS Technologi
Meir-Keeler Type Contractions on Js-Metric Spaces and Related Fixed Point Theorems
No full textKARAPINAR, ERDAL/0000-0002-6798-3254We introduce two classes of Meir-Keeler type contractions in the framework of JS-metric spaces introduced by Jleli and Samet (2015). For each class, a fixed point result is derived. Some interesting consequences which follow from our obtained results are discussed.King Saud University (Saudi Arabia)The second author extends his appreciation to Distinguished Scientist Fellowship Program (DSFP) at King Saud University (Saudi Arabia)
Eddy-Induced Growth Rate of Low-Frequency Variability and Its Mid- to Late Winter Suppression in the Northern Hemisphere
No full textSynoptic eddy and low-frequency flow (SELF) feedback plays an important role in reinforcing low-frequency variability (LFV). Recent studies showed that an eddy-induced growth (EIG) or instability makes a fundamental contribution to the maintenance of LFV. To quantify the efficiency of the SELF feedback, this study examines the spatiotemporal features of the empirical diagnostics of EIG and its associations with LFV. The results show that, in terms of eddy vorticity forcing, the EIG rate of LFV is generally larger (smaller) in the upper (lower) troposphere, whereas, in terms of eddy potential vorticity forcing, it is larger in the lower troposphere to partly balance the damping effect of surface friction. The local EIG rate shows a horizontal spatial distribution that corresponds to storm-track activity, which tends to be responsible for maintaining LFV amplitudes and patterns as well as sustaining eddy-driven jets. In fact, the EIG rate has a well-defined seasonality, being generally larger in cold seasons and smaller in the warmest season, and this seasonality is stronger in the Northern Hemisphere than in the Southern Hemisphere. This study also reveals a mid-to late winter (January-March) suppression of the EIG rate in the Northern Hemisphere, which indicates a reduced eddy feedback efficiency and may be largely attributed to the eddy kinetic energy suppression and the midlatitude zonal wind maximum in the midwinter of the Northern Hemisphere.O (subject to Restrictions below, author can archive publisher's version/PDF)1144sciescopu
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