1,146 research outputs found
American Women Writers: Amy M. Clark
No full textA 2011 conversation with the author Amy M. Clark about her life and the inspiration for her work
Sparrows can't sing : East End kith and kinship in the 1960s
No full textSparrows Can’t Sing (1963) was the only feature film directed by
the late and much lamented Joan Littlewood. Set and filmed in
the East End, where she worked for many years, the film deserves
more attention than it has hitherto received. Littlewood’s career
spanned documentary (radio recordings made with Ewan MacColl
in the North of England in the 1930s) to directing for the stage
and the running of the Theatre Royal in London’s Stratford East,
often selecting material which aroused memories in local audiences
(Leach 2006: 142). Many of the actors trained in her Theatre
Workshop subsequently became better known for their appearances
on film and television. Littlewood herself directed hardly any material
for the screen: Sparrows Can’t Sing and a 1964 series of television
commercials for the British Egg Marketing Board, starring Theatre
Workshop’s Avis Bunnage, were rare excursions into an area of practice
which she found constraining and unamenable (Gable 1980: 32).
The hybridity and singularity of Littlewood’s feature may answer,
in some degree, for its subsequent neglect. However, Sparrows Can’t
Sing makes a significant contribution to a group of films made in
Britain in the 1960s which comment generally on changes in the
urban and social fabric. It is especially worthy of consideration,
I shall argue, for the use which Littlewood made of a particular
community’s attitudes – sentimental and critical – to such changes and
for its amalgamation of an attachment to documentary techniques
(recording an aural landscape on location) with a preference for nonnaturalistic
delivery in performance
Funny Feminism: Reading the Texts and Performances of Viola Spolin, Tina Fey and Amy Poehler, and Amy Schemer
No full textThis study examines the feminism of Viola Spolin, Tina Fey and Amy Poehler, and Amy
Schumer, all of whom, in some capacity, are involved in the contemporary practice and performance of feminist comedy. Using various feminist texts as tools, the author contextually and theoretically situates the women within particular feminist ideologies, reading their texts, representations, and performances as nuanced feminist assertions. Building upon her own experiences and sensations of being a fan, the author theorizes these comedic practitioners in relation to their audiences, their fans, influencing the ways in which young feminist relate to themselves, each other, their mentors, and their role models. Their articulations, in other words, affect the ways feminism is contemporarily conceived, and sometimes, humorously and contentiously advocated
The molecular pathogenesis of myeloproliferative neoplasms
No full textMyeloproliferative neoplasms (MPNs) are a heterogeneous group of haematological stem cellmalignancies characterised by proliferation of one or more cells of the myeloid lineage. The molecularinvestigation of MPN was revolutionized in 2005 by the finding that approximately 95% of cases withpolycythaemia vera (PV) and 50-60% of cases of essential thrombocythaemia (ET) and primarymyelofibrosis (PMF) are characterised by a single acquired mutation, JAK2 V617F. My study hasfocused on four principal areas:(i) Involvement of V617F in other myeloid disorders. After developing sensitive methods todetect and quantify V617F, this mutation was identified in 17% of cases of atypical chronic myeloidleukaemia (17/99) as well as other atypical MPN, thus demonstrating that it was more widelyinvolved in myeloid disorders that initially thought. Homozygosity of V617F was shown to have arisenby acquired uniparental disomy (UPD) and examination of two cases with V617F plus either KITD816V or BCR-ABL demonstrated that the mutations had arisen in independent clones.(ii) In vitro assays to predict imatinib sensitivity. Haemopoietic colony and liquid cultures wereused to determine if peripheral blood or bone marrow cells from atypical MPN cases (n=200) weresensitive to imatinib. Of those that responded in one or both cultures (n=185) some had knownabnormalities of PDGFRA or PDGFRB, but a significant minority proved negative for all molecular testssuggesting the presence of uncharacterised imatinib-sensitive mutations.(iii) V617F as a marker of response to therapy. JAK2 V617F was used as a molecular marker tomonitor the response of PV patients (n=21) to therapy with imatinib and interferon-?. Neithertherapy eradicated V617F but there was a modest reduction in %V617F which correlated withhaematological response. By contrast, in those patients that did not respond (n=13) the %V617Fmarginally increased.(iv) Genetic predisposition to MPN. Whilst investigating the possible contribution of JAK2 singlenucleotide polymorphisms to the phenotypic diversity associated with V617F, marked skewing ofalleles associated with the mutation was observed. Further investigation revealed that V617Fassociateddisease is strongly associated with a specific constitutional JAK2 haplotype, designated46/1, in all three disease entities compared to healthy controls (PV, n=192, P=2.9x10-16; ET, n=78,P=8.2x10-9 and MF, n=41, P=8.0x10-5). Furthermore, allele-specific PCR demonstrated that V617Fspecifically arises on the 46/1 allele in most cases. The 46/1 JAK2 haplotype thus predisposes to thedevelopment of V617F associated MPNs (OR=3.7; 95% CI 3.1-4.3) and provides a model whereby aconstitutional genetic factor is associated with an increased risk of acquiring a specific somaticmutation
The air microwave yield (AMY) experiment - A laboratory measurement of the microwave emission from extensive air showers
No full textThe AMY experiment aims to measure the microwave bremsstrahlung radiation (MBR) emitted by air-showers secondary electrons accelerating in collisions with neutral molecules of the atmosphere. The measurements are performed using a beam of 510 MeV electrons at the Beam Test Facility (BTF) of Frascati INFN National Laboratories. The goal of the AMY experiment is to measure in laboratory conditions the yield and the spectrum of the GHz emission in the frequency range between 1 and 20 GHz. The final purpose is to characterise the process to be used in a next generation detectors of ultra-high energy cosmic rays. A description of the experimental setup and the first results are presented. © Copyright owned by the author(s) under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike Licence
James McCune Smith Predicted African American Preeminence in U.S. Art and Culture
No full textJames McCune Smith (1813–1865) was an African American physician, author, intellectual, community leader, and antislavery activist. He believed that the racial caste system of the United States was perpetuated not only by the slave system but by widely entrenched negative attitudes towards people of African descent, both outside and within the African American community. To counteract popular prejudice and to promote African American confidence and unity, he wrote widely on the abilities, accomplishments, and contributions of people of African descent, both historical and contemporary. This article examines McCune Smith’s theory that African Americans would play a formative and outsize role in the development of United States artistic and intellectual culture. From his time to ours, McCune Smith’s striking prediction was fulfilled to a degree that even he, inspired with the confidence his 1841 lecture “The Destiny of the People of Color” (published 1843) reveals, might marvel at
Identification of Sensitive Outcome Measures of Participation for Children With Autism
No full textAbstract
Date Presented 4/1/2017
Mixed methods were used to identify valid, reliable, performance-based outcome measures for daily living skills and socialization for children ages 6–9 with ASD. We chose the best measures. Feasibility and validity testing for use in a future comparative study is under way.
Primary Author and Speaker: Roseann C. Schaaf
Additional Authors and Speakers: Amy Carroll, Elizabeth M. Ridgway</jats:p
Life and work of James McCune Smith (1813-1865)
No full textJames McCune Smith (1813-1865) was the first African American physician to practice in the United States with a medical degree. He was among the most educated African Americans of his day, having earned three degrees at the University of Glasgow. McCune Smith was also the first African American to have work published in European and US medical journals; an early and central leader in the Colored Convention Movement; author of a series of experimental essays foundational to African American literature; and among the most prolific authors in the antebellum African American press. His immense influence is revealed in myriad primary and secondary sources relating to the African American struggle for freedom before and during the US Civil War and to the African American literary tradition. Yet while he is so often cited by contemporaries and later scholars as a leader and major influence in African American intellectual, cultural, and civil rights history, McCune Smith has yet to be the subject of a full-length dedicated biography. This thesis is written with the view that McCune Smith is among the most significant figures in American history to lack a full biography. It seeks, among other things, to remedy this lack, filling in gaps in existing literature on McCune Smith’s origins and on major events and themes in his life. It will do so in a series of six chapters. Chapter One explores McCune Smith’s origins and life in New York City and argues that this context is vital for understanding McCune Smith’s lifetime of achievement and activism. Chapter Two argues that McCune Smith was the first full-fledged African American polymath as well as the preeminent African American intellectual of the 19th century. Chapter Three argues that the significance of McCune Smith’s pioneering medical career may lie more in the holistic nature of the practice he established than in the fact that he broke multiple racial barriers that African Americans faced in that field. Chapter Four argues that that McCune Smith played a more central and enduring role in the history of the African American press than is generally recognized in the relevant literature; that the subtle, complex, and often controversial ideas he expressed in his articles may have caused him to be marginalized by scholars; and that these ideas represent significant contributions to many arenas of thought. Chapter Five argues that McCune Smith’s broad conception of slavery drove his lifelong opposition to it in all its forms, from what he described as the caste system which oppressed African Americans in the North to the legalised system of chattel slavery in the South. Chapter Six traces the origins and development of McCune Smith as a scientific thinker and author. It argues that his thinking in these fields was centered on one foundational theory: that humankind consisted of a single race, classifiable into groups or ‘races’ only according to mutable characteristics caused by local circumstances. It also argues that among McCune Smith’s most significant contributions to what he called the ‘dawning science of race-history’ was his development of the theory that African Americans had arisen as an indigenous American people
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Vassar Miller prize in poetry series
No full textWith poems that combine the self-scrutiny of Philip Larkin with the measure of Elizabeth Bishop, Amy M. Clark burnishes her first collection, Stray Home, with exquisite understatement and formal control. Sweeter than Larkin and more intimate than Bishop, these poems address the suppressed pain and shame of living as a childless woman in a world of mothers, the dissociation attendant on depression and fraught family relationships, and the search for a sense of belonging in the face of dislocation. Stray Home cuts deeply to discover the buried emotions and insights universal to all suffering and compassionate human beings. “Clark is able to imbue our small, usually overlooked moments with unexpected grandeur. A quiet humor is employed in service of her twin gifts, imagination and metaphor. This is an accomplished, deft, and important debut.”—Beth Ann Fennelly, author of Tender Hooks and judg
Review: Joseph Urban: Unlocking an Art Deco Bedroom
No full textReview of Joseph Urban: Unlocking an Art Deco Bedroom by Amy Miller Dehan. Cincinnati Art Museum in association with D Giles Limited, February 2022. 128 p. ill. ISBN 978-1-911282-56-3 (h/c), $49.95. Reviewed July 2022 by Sara Mautino, Librarian, Oklahoma State University School of Architecture - Cunningham Architecture Library, Oklahoma State University Libraries, [email protected]
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