6,419 research outputs found
Anti-arthritic activity in rats of some phosphinegold(I) thionucleobases and related thiolates
No full textA number of phosphinegold(I) thiolates where, generally, the thiolate is derived from a thionucleobase, have been screened for anti-arthritic activity in Dark Agouti rats, a gold sensitive model for arthritis. Potency and toxicity data showed that, generally, the Ph3P derivatives and species based on thiopurines were the most effective and that with other complexes enhanced activity was accompanied by greater toxicity.Michael W. Whitehouse, Peter D. Cookson, George Siasios, and Edward R. T. Tiekin
The Concept of Genius in D. A. Granin’s Work (Based on the Novel “Evenings with Peter the Great”)
No full textThe article deals with D. A. Granin’s concept of history as presented in the novel “Evenings with Peter the Great”. The author of the novel argues that historical process is driven and streamlined by people endowed with rare gifts and deep urge to create such as the first Russian emperor Peter the Great
Zechariah 9-14 as the substructure of 1 Peter’s eschatological program
No full textThe principal aim of this study is to discern what has shaped the author of 1 Peter to regard Christian suffering as a necessary (1.6) and to-be-expected (4.12) component of faithful allegiance to Jesus Christ. Most research regarding suffering in 1 Peter has limited the scope of inquiry to two particular aspects—its cause and nature, and the strategies that the author of 1 Peter employs in order to enable his addressees to respond in faithfulness. There remains, however, the need for a comprehensive explanation for the source that has generated 1 Peter’s theology of Christian suffering. If Jesus truly is the Christ, God’s chosen redemptive agent who has come to restore God’s people, then how can it be that Christian suffering is a necessary part of discipleship after his coming, death and resurrection? What led the author of 1 Peter to such a startling conclusion, which seems to runs against the grain of the eschatological hopes and expectations of Jewish restoration ideology?
This thesis analyzes the appropriation of shepherd and fiery trials imagery,
and argues that the author of 1 Peter is dependent upon Zechariah 9-14 for his
theology of Christian suffering. Said in another way, the eschatological program of
Zechariah 9-14, read through the lens of the Gospel, functions as the substructure
for 1 Peter’s eschatology and thus its theology of Christian suffering.
In support of this hypothesis, this study highlights the fact that Zechariah 9-
14 was available and appropriated in early Christianity, in particular in the Passion
Narrative tradition; that the shepherd imagery of 1 Pet 2.25 is best understood
within the milieu of the Passion Narrative tradition, and that it alludes to the
eschatological program of Zechariah 9-14; that the fiery trials imagery found in 1
Peter 1.6-7 and 1 Pet 4.12 is distinct from that which we find in Greco-Roman and OT
wisdom sources, and that it shares exclusive parallels with some unique features of
the eschatological program of Zechariah 9-14; that Zechariah 9-14 offers a more
satisfying explanation for the modification of Isa 11.2 in 1 Pet 4.14, the transition
from 4.12-19 to 5.1-4, why Peter has oriented his letter with the term διασπορά,
and why he has described his addresses as οἶκος τοῦ θεοῦ; and finally that 1 Peter
contains an implicit foundational narrative that shares distinct parallels with the
eschatological program of Zechariah 9-14.
We can conclude that 1 Peter offers a unique vista into the way in which at
least one early Christian witness came to understand and to communicate the fact
that Christian suffering was a necessary feature of faithful allegiance to Jesus Christ
Copyright & Your Research
No full textAs publishing options increase in number, it is ever more important that university authors manage their copyrights in a way that ensures maximum benefit to them and to the university. Peter Hirtle, Senior Policy Advisor in the Cornell University Library and a Research Fellow at the Berkman Center for Internet & Society at Harvard University, will give an overview of the sometimes puzzling issues surrounding creating, securing, owning, and using copyrighted works. Topics will include author agreements and contracts, the public access requirements in some federal grants, new publishing options, and the management of your copyrights. The session will benefit those who want to gain a better understanding of the changing nature of scholarly communications. PRESENTATION BY Peter B. Hirtle, Senior Policy Advisor, Cornell University Library, and Research Fellow, Berkman Center for Internet Security and Society, Harvard Universit
EPOSIUM 1992: GENETIC ENGINEERING: THE NEW CHALLENGE: CONFERENCE PROCEEDINGS AND ESSAY COMPETITION
No full textIntroduction / Paul Braendli -- Opening address / Gebhard Ziller -- Pt. I. Conference proceedings -- Morning session -- Chairman: Dieter Thierbach -- The Human Genome Project / Sir Walter Bodmer -- Gaining mastery over life / Axel Kahn -- Technology and applications / Mathias Uhlén -- Social acceptance / Walter P. von Wartburg -- The ethics of patenting life / David King -- Philosophy and ethics / Baroness Warnock -- Challenge for the law / Joseph Straus -- Afternoon session -- Chairman: Clive Cookson -- Questions and discussion -- Summary -- Pt. II. 1992 essay competition: "Patents and ethics in the context of modern technology" / Compiled by Fabienne Gauye Wolhändler -- Introduction -- Prize-winners -- I. Group A: first prize -- 1. Patentierung menschlicher Gene, Zellen und Körperteile? Zur ethischen Dimension des Patentrechts / Rainer Moufang -- 2. Was hat Ethik, das hintergründige Immaterielle, mit Technik, dem vordergründig Materiellen, zu tun? / Angelika Andres -- Group A: second prize -- 1. Der menschliche Körper im Patentrecht / Bernd Appel -- 2. Spannungsverhältnis zwischen Patent und Ethik am Beispiel moderner Techniken aus den Bereichen Biotechnologie, Chemie/Pharmazie, Elektrotechnik und Mechanik / Dietrich Wilhelm Schacht -- II. Group B: second prize -- l. Ethique et brevet : La valeur et Ie code / Yves Grandjean -- 2. Moral dilemmas in the history of patent legislation / Bryan Karet -- 3. Who in our society should take on the responsibility of deciding what is ethically or morally just, and what are the criteria upon which decisions should be based? / Peter Egerer -- III. Special recognition award -- Of rodents and elephants (a week in the life of the European patent in the name of A. Shrew Co.) / Charles Hardin
Critical pedagogy in hard financial times
No full textPeter Mayo takes issue with education financing not from an economic or technical
viewpoint, but from a philosophical and systemic one, drawing on critical pedagogy.
There is no sense, this article argues, to talk of higher education or its funding without
reference to the capitalist system which the mainstream education discourse reaffirms. The author concludes with an alternative vision of lifelong learning as a social act for the creation and enhancing of democratic spaces, reflected in the ongoing global “Occupy” protests for social equality.peer-reviewe
A study of two wireless telecommunications companies' globalization strategies : an analysis of Vodafone's and NTT DoCoMo's foreign investments
No full textThesis (M.B.A.)--Massachusetts Institute of Technology, Sloan School of Management, 2003 [first author]; and, (S.M.)--Massachusetts Institute of Technology, Sloan School of Management, 2003 [second author].Includes bibliographical references (leaves 117-119).by Hyungchul Joo and Peter D. Honkanen.M.B.A.S.M
NRF2 activation restores disease related metabolic deficiencies in olfactory neurosphere-derived cells from patients with sporadic Parkinson's Disease
No full textExtent: 14p.Background: Without appropriate cellular models the etiology of idiopathic Parkinson’s disease remains unknown. We recently reported a novel patient-derived cellular model generated from biopsies of the olfactory mucosa (termed olfactory neurosphere-derived (hONS) cells) which express functional and genetic differences in a disease-specific manner. Transcriptomic analysis of Patient and Control hONS cells identified the NRF2 transcription factor signalling pathway as the most differentially expressed in Parkinson’s disease. Results: We tested the robustness of our initial findings by including additional cell lines and confirmed that hONS cells from Patients had 20% reductions in reduced glutathione levels and MTS [3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)- 2-(4-sulfophenyl)-2H-tetrazolium, inner salt] metabolism compared to cultures from healthy Control donors. We also confirmed that Patient hONS cells are in a state of oxidative stress due to higher production of H2O2 than Control cultures. siRNA-mediated ablation of NRF2 in Control donor cells decreased both total glutathione content and MTS metabolism to levels detected in cells from Parkinson’s Disease patients. Conversely, and more importantly, we showed that activation of the NRF2 pathway in Parkinson’s disease hONS cultures restored glutathione levels and MTS metabolism to Control levels. Paradoxically, transcriptomic analysis after NRF2 pathway activation revealed an increased number of differentially expressed mRNAs within the NRF2 pathway in L-SUL treated Patient-derived hONS cells compared to L-SUL treated Controls, even though their metabolism was restored to normal. We also identified differential expression of the PI3K/AKT signalling pathway, but only post-treatment. Conclusions: Our results confirmed NRF2 as a potential therapeutic target for Parkinson’s disease and provided the first demonstration that NRF2 function was inducible in Patient-derived cells from donors with uniquely varied genetic backgrounds. However, our results also demonstrated that the response of PD patient-derived cells was not co-ordinated in the same way as in Control cells. This may be an important factor when developing new therapeutics.Anthony L. Cook, Alejandra M. Vitale, Sugandha Ravishankar, Nicholas Matigian, Greg T. Sutherland, Jiangou Shan, Ratneswary Sutharsan, Chris Perry, Peter A. Silburn, George D. Mellick, Murray L. Whitelaw, Christine A. Wells, Alan Mackay-Sim and Stephen A. Woo
Coauthor prediction for junior researchers
No full textResearch collaboration can bring in different perspectives and generate more productive results. However, finding an appropriate collaborator can be difficult due to the lacking of sufficient information. Link prediction is a related technique for collaborator discovery; but its focus has been mostly on the core authors who have relatively more publications. We argue that junior researchers actually need more help in finding collaborators. Thus, in this paper, we focus on coauthor prediction for junior researchers. Most of the previous works on coauthor prediction considered global network feature and local network feature separately, or tried to combine local network feature and content feature. But we found a significant improvement by simply combing local network feature and global network feature. We further developed a regularization based approach to incorporate multiple features simultaneously. Experimental results demonstrated that this approach outperformed the simple linear combination of multiple features. We further showed that content features, which were proved to be useful in link prediction, can be easily integrated into our regularization approach. © 2013 Springer-Verlag
Microscope images of cryptogam spores (A–C), other gymnosperm pollen (D–I) and monocot pollen (J–L) from the Río Zeballos locality.
No full text<p>Suggested extant affinities, if known, are shown in parentheses. A, <i>Cyathidites</i> sp. (Cyatheaceae). B, <i>Ischyosporites areapunctata</i> (Stuchlik) Barreda (Dicksoniaceae). C, <i>Reboulisporites fuegiensis</i> Zamaloa & E.J. Romero (Aytoniaceae). D, <i>Phyllocladidites mawsonii</i> Cookson ex Couper (<i>Lagarostrobos</i>). E, <i>Podocarpidites marwickii</i> Couper (<i>Podocarpus</i>/<i>Prumnopitys</i>). F, <i>Podosporites microsaccatus</i> (Couper) M.E. Dettmann (<i>Microcachrys</i>). G, <i>Dacrycarpites australiensis</i> Cookson & K.M. Pike (<i>Dacrycarpus</i>). H, <i>Dacrydiumites florinii</i> Cookson & K.M. Pike var. (<i>Dacrydium</i>). I, <i>Microcachryidites antarcticus</i> Cookson (<i>Microcachrys</i>). J, <i>Liliacidites</i> cf. <i>L.</i> r<i>egularis</i> Archangelsky (Liliaceae). K, <i>Luminidites</i> sp. (Agavaceae). L, <i>Proxapertites</i> sp. (Araceae/Arecaceae). Scale bars: A–K, 10 µm; L, 20 µm.</p
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