2,568 research outputs found
Myxococcus vastator Chambers & Sparks & Sydney & Livingstone & Cookson & Whitworth 2020, sp. nov.
No full textMyxococcus vastator sp. nov. Myxococcus vastator (vas.ta’tor L. masc. n. vastator the ravager, after its ability to devastate colonies of prey cells). Vegetative cells are Gram-negative bacilli tapering slightly at the ends, measuring 0.6–0.7 m m 3.0–6.0 m m in electron micrographs. Colonies exhibit swarming motility and appear pale brown on VY-2 agar (w/v 0.5% dried baker’s yeast, 0.1% CaCl 2 2H 2 O, and 1.5% agar). Fruiting bodies are irregular spheroids, orange in color. Aerobic growth was observed at 30 C and at pH 8.0–9.0. Growth was unaffected by the addition of 1% NaCl. Hydrolyzes arginine and urea. Assimilates malate. Cells prey with low efficiency upon E. coli TOP 10, Cl. nebraskensis DSM 7483, and U. maydis DSM 14603. DNA GC content is 69.9 mol%. The draft genome sequence of AM301 T is available from GenBank (accession JAAIYB01). The type strain (AM301 T ¼ NCCB 100768 T ¼ NBBC 114352 T) was isolated from soil collected in the parish of Llanfairpwllgwyngyllgogerychwyrndrobwlll lantysiliogogogoch, UK (gridref 53.22 N 4.19 W).Published as part of Chambers, James, Sparks, Natalie, Sydney, Natashia, Livingstone, Paul G, Cookson, Alan R & Whitworth, David E, 2020, Comparative Genomics and Pan-Genomics of the Myxococcaceae, including a Description of Five Novel Species: Myxococcus eversor sp. nov., Myxococcus llanfairpwllgwyngyllgogerychwyrndrobwllllantysiliogogogochensis sp. nov., Myxococcus vastator sp. nov., Pyxidicoccus caerfyrddinensis sp. nov., and Pyxidicoccus trucidator sp. nov., pp. 2289-2302 in Genome Biology and Evolution 12 (12) on page 2300, DOI: 10.1093/gbe/evaa212, http://zenodo.org/record/456162
Myxococcus llanfairpwllgwyngyllgogerychwyrndrobwllllantysiliogogogochensis Chambers, Sparks, Sydney, Livingstone, Cookson & Whitworth, 2020, sp. nov.
No full textMyxococcus llanfairpwllgwyngyllgogerychwyrndrobwllllantysiliogogogochensis sp. nov. Myxococcus llanfairpwllgwyngyllgogerychwyrndrobwllllantysiliogogogochensis, (llan.fair.pwll.gwyn.gyll.gog.er.ych.wyrn.dro.bwllll.ant.ysil.iog.ogogoch.en’sis. N.L. masc. adj. llanfairpwllgwyngyllgogerychwyrndrobwllllantysiliogogogo chensis, pertaining to llanfairpwllgwyngyllgogerychwyrndrobwllllantysiliogogogoch, reflecting its isolation from soil collected in that parish [gridref 53.22 N 4.19 W]). Vegetative cells are Gram-negative bacilli tapering slightly at the ends, measuring 0.4–0.6 m m 4.0–7.0 m m in electron micrographs. Colonies exhibit swarming motility and appear pale brown on VY-2 agar (w/v 0.5% dried baker’s yeast, 0.1% CaCl 2 2H 2 O, and 1.5% agar). Fruiting bodies are irregular spheroids, orange in color. Aerobic growth was observed at 30 and 35 C and at pH 5.0–9.0. Growth was unaffected by the addition of 1–4% NaCl. Hydrolyzes esculin, gelatin, p -nitrophenyl- B -D- galactopyranoside, and urea. Assimilates N -acetyl-glucosamine, adipate, arabinose, glucose, malate, maltose, mannitol, mannose, and phenyl acetate. Cells prey with low efficiency upon E. coli TOP 10, Cl. nebraskensis DSM 7483, and U. maydis. DNA GC content is 68.7 mol%. The draft genome sequence of AM 401 T is available from GenBank (accession VIFM 01). The type strain (AM401 T ¼ NBRC 114351 T ¼ NBBC 100770 T) was isolated from soil collected in the parish of Llanfairpwllgwyngyllgo gerychwyrndrobwllllantysiliogogogoch, UK (gridref 53.22 N 4.19 W).Published as part of Chambers, James, Sparks, Natalie, Sydney, Natashia, Livingstone, Paul G, Cookson, Alan R & Whitworth, David E, 2020, Comparative Genomics and Pan-Genomics of the Myxococcaceae, including a Description of Five Novel Species: Myxococcus eversor sp. nov., Myxococcus llanfairpwllgwyngyllgogerychwyrndrobwllllantysiliogogogochensis sp. nov., Myxococcus vastator sp. nov., Pyxidicoccus caerfyrddinensis sp. nov., and Pyxidicoccus trucidator sp. nov., pp. 2289-2302 in Genome Biology and Evolution 12 (12) on page 2300, DOI: 10.1093/gbe/evaa212, http://zenodo.org/record/456162
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Alan R. Stowers writes Dr. Hector P. Garcia about the latter's recent visit to CCSU campus (correspondence)
No full textAlan R. Stowers, Director of the Corpus Christi State University Public Information Office, sends Dr. Hector P. Garcia copies of the campus newspaper's article about his latest talk on campus and informs him that his comments have been passed along to the author
Pyxidicoccus caerfyrddinensis Chambers & Sparks & Sydney & Livingstone & Cookson & Whitworth 2020, sp. nov.
No full textPyxidicoccus caerfyrddinensis sp. nov. Pyxidicoccus caerfyrddinensis (caer.fyrdd.in.en’sis N.L. masc. adj. caerfyrddinensis from Caerfyrddin, reflecting its isolation from soil sampled near Carmarthen [the Anglicized name for Caerfyrddin], Wales [51.86 N 4.31 W]). Vegetative cells are Gram-negative bacilli tapering slightly at the ends, measuring 0.7–0.8 m m 3.0–8.0 m m in electron micrographs. Colonies exhibit swarming motility and appear pale brown on VY-2 agar (w/v 0.5% dried baker’s yeast, 0.1% CaCl 2 2H 2 O, and 1.5% agar). Fruiting bodies are irregular spheroids, orange in color. Aerobic growth was observed at 30–40 C and at pH 6.0–9.0. Growth was unaffected by the addition of 1–3% NaCl. Hydrolyzes arginine, esculin, gelatin, p -nitrophenyl- B - D- galactopyranoside, and urea. Cells prey efficiently on Cl. nebraskensis DSM 7483, and with low efficiency upon E. coli TOP 10 and U. maydis DSM 14603. DNA GC content is 70.2 mol%. The draft genome sequence of CA032 A T is available from GenBank (accession JAAIYA01). The type strain (CA032 A T ¼ NCCB 100776 T ¼ NBBC 114353 T) was isolated from soil collected in Carmarthen, UK (gridref 51.86 N 4.31 W).Published as part of Chambers, James, Sparks, Natalie, Sydney, Natashia, Livingstone, Paul G, Cookson, Alan R & Whitworth, David E, 2020, Comparative Genomics and Pan-Genomics of the Myxococcaceae, including a Description of Five Novel Species: Myxococcus eversor sp. nov., Myxococcus llanfairpwllgwyngyllgogerychwyrndrobwllllantysiliogogogochensis sp. nov., Myxococcus vastator sp. nov., Pyxidicoccus caerfyrddinensis sp. nov., and Pyxidicoccus trucidator sp. nov., pp. 2289-2302 in Genome Biology and Evolution 12 (12) on page 2301, DOI: 10.1093/gbe/evaa212, http://zenodo.org/record/456162
Myxococcus eversor Chambers & Sparks & Sydney & Livingstone & Cookson & Whitworth 2020, sp. nov.
No full text<p> <i>Myxococcus eversor</i> sp. nov.</p> <p> <i>Myxococcus eversor</i> (e.ver’sor L. masc. n. <i>eversor</i> the destroyer, reflecting its destruction of prey cells).</p> <p> Vegetative cells are Gram-negative bacilli tapering slightly at the ends, measuring 0.6–0.7 <b>m</b> m 3.0–8.0 <b>m</b> m in electron micrographs. Colonies exhibit swarming motility and appear pale brown on VY-2 agar (w/v 0.5% dried baker’s yeast, 0.1% CaCl 2 2H 2 O, and 1.5% agar). Fruiting bodies are irregular spheroids, orange in color. Aerobic growth was observed at 30–40 C, at pH 5.0–9.0, and with the addition of 1–4% NaCl. Hydrolyzes arginine, esculin, gelatin, <i>p</i> -nitrophenyl- <i>B</i> -D-galactopyranoside, and urea. Assimilates <i>N</i> -acetyl-glucosamine, adipate, arabinose, caprate, citrate, gluconate, glucose, malate, maltose, mannitol, mannose, and phenyl acetate. Cells prey with low efficiency upon <i>E. coli</i> TOP 10, <i>Cl. nebraskensis</i> DSM 7483, and <i>U. maydis</i> DSM 14603.</p> <p> DNA GC content is 68.9 mol%. The draft genome sequence of AB053B T is available from GenBank (accession JAAIXY01). The type strain (AB053B T <b>¼</b> NCCB 100767 T <b>¼</b> T NBRC 114350) was isolated from soil collected from Aberystwyth University, UK (gridref 52.41 N 4.08 W).</p>Published as part of <i>Chambers, James, Sparks, Natalie, Sydney, Natashia, Livingstone, Paul G, Cookson, Alan R & Whitworth, David E, 2020, Comparative Genomics and Pan-Genomics of the Myxococcaceae, including a Description of Five Novel Species: Myxococcus eversor sp. nov., Myxococcus llanfairpwllgwyngyllgogerychwyrndrobwllllantysiliogogogochensis sp. nov., Myxococcus vastator sp. nov., Pyxidicoccus caerfyrddinensis sp. nov., and Pyxidicoccus trucidator sp. nov., pp. 2289-2302 in Genome Biology and Evolution 12 (12)</i> on page 2300, DOI: 10.1093/gbe/evaa212, <a href="http://zenodo.org/record/4561628">http://zenodo.org/record/4561628</a>
Alan Moore Comics as Performance, Fiction as Scalpel
No full textEclectic British author Alan Moore (b. 1953) is one of the most acclaimed and controversial comics writers to emerge since the late 1970s. He has produced a large number of well-regarded comic books and graphic novels while also making occasional forays into music, poetry, performance, and prose. In Alan Moore: Comics as Performance, Fiction as Scalpel , Annalisa Di Liddo argues that Moore employs the comics form to dissect the literary canon, the tradition of comics, contemporary society, and our understanding of history. The book considers Moore's narrative strategies and pinpoints the main thematic threads in his works: the subversion of genre and pulp fiction, the interrogation of superhero tropes, the manipulation of space and time, the uses of magic and mythology, the instability of gender and ethnic identity, and the accumulation of imagery to create satire that comments on politics and art history. Examining Moore's use of comics to scrutinize contemporary culture, Di Liddo analyzes his best-known works-- Swamp Thing, V for Vendetta, Watchmen, From Hell, Promethea , and Lost Girls . The study also highlights Moore?s lesser-known output, such as Halo Jones, Skizz , and Big Numbers , and his prose novel Voice of the Fire. Alan Moore: Comics as Performance, Fiction as Scalpel reveals Moore to be one of the most significant and distinctly postmodern comics creators of the last quarter-century.Intro -- Contents -- Preface and Acknowledgments -- Introduction -- CHAPTER 1. Formal Considerations on Alan Moore's Writing -- CHAPTER 2. Chronotopes: Outer Space, the Cityscape, and the Space of Comics -- CHAPTER 3. Moore and the Crisis of English Identity -- CHAPTER 4. Finding a Way into Lost Girls -- Conclusion -- Notes -- Bibliography -- Index -- A -- B -- C -- D -- E -- F -- G -- H -- I -- J -- K -- L -- M -- N -- O -- P -- Q -- R -- S -- T -- U -- V -- W -- Y -- ZEclectic British author Alan Moore (b. 1953) is one of the most acclaimed and controversial comics writers to emerge since the late 1970s. He has produced a large number of well-regarded comic books and graphic novels while also making occasional forays into music, poetry, performance, and prose. In Alan Moore: Comics as Performance, Fiction as Scalpel , Annalisa Di Liddo argues that Moore employs the comics form to dissect the literary canon, the tradition of comics, contemporary society, and our understanding of history. The book considers Moore's narrative strategies and pinpoints the main thematic threads in his works: the subversion of genre and pulp fiction, the interrogation of superhero tropes, the manipulation of space and time, the uses of magic and mythology, the instability of gender and ethnic identity, and the accumulation of imagery to create satire that comments on politics and art history. Examining Moore's use of comics to scrutinize contemporary culture, Di Liddo analyzes his best-known works-- Swamp Thing, V for Vendetta, Watchmen, From Hell, Promethea , and Lost Girls . The study also highlights Moore?s lesser-known output, such as Halo Jones, Skizz , and Big Numbers , and his prose novel Voice of the Fire. Alan Moore: Comics as Performance, Fiction as Scalpel reveals Moore to be one of the most significant and distinctly postmodern comics creators of the last quarter-century.Description based on publisher supplied metadata and other sources.Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, YYYY. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries
NRF2 activation restores disease related metabolic deficiencies in olfactory neurosphere-derived cells from patients with sporadic Parkinson's Disease
No full textExtent: 14p.Background: Without appropriate cellular models the etiology of idiopathic Parkinson’s disease remains unknown. We recently reported a novel patient-derived cellular model generated from biopsies of the olfactory mucosa (termed olfactory neurosphere-derived (hONS) cells) which express functional and genetic differences in a disease-specific manner. Transcriptomic analysis of Patient and Control hONS cells identified the NRF2 transcription factor signalling pathway as the most differentially expressed in Parkinson’s disease. Results: We tested the robustness of our initial findings by including additional cell lines and confirmed that hONS cells from Patients had 20% reductions in reduced glutathione levels and MTS [3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)- 2-(4-sulfophenyl)-2H-tetrazolium, inner salt] metabolism compared to cultures from healthy Control donors. We also confirmed that Patient hONS cells are in a state of oxidative stress due to higher production of H2O2 than Control cultures. siRNA-mediated ablation of NRF2 in Control donor cells decreased both total glutathione content and MTS metabolism to levels detected in cells from Parkinson’s Disease patients. Conversely, and more importantly, we showed that activation of the NRF2 pathway in Parkinson’s disease hONS cultures restored glutathione levels and MTS metabolism to Control levels. Paradoxically, transcriptomic analysis after NRF2 pathway activation revealed an increased number of differentially expressed mRNAs within the NRF2 pathway in L-SUL treated Patient-derived hONS cells compared to L-SUL treated Controls, even though their metabolism was restored to normal. We also identified differential expression of the PI3K/AKT signalling pathway, but only post-treatment. Conclusions: Our results confirmed NRF2 as a potential therapeutic target for Parkinson’s disease and provided the first demonstration that NRF2 function was inducible in Patient-derived cells from donors with uniquely varied genetic backgrounds. However, our results also demonstrated that the response of PD patient-derived cells was not co-ordinated in the same way as in Control cells. This may be an important factor when developing new therapeutics.Anthony L. Cook, Alejandra M. Vitale, Sugandha Ravishankar, Nicholas Matigian, Greg T. Sutherland, Jiangou Shan, Ratneswary Sutharsan, Chris Perry, Peter A. Silburn, George D. Mellick, Murray L. Whitelaw, Christine A. Wells, Alan Mackay-Sim and Stephen A. Woo
The construction of Karen Karnak: The multi-author-function
No full textThis thesis is situated within the comparatively recent developments of Web 2.0 and the emergence of interactive WikiMedia, and explores the mode of authorship within a Read/Write culture compared to that of a Read/Only tradition. The hypothesis of this study is that the role of the audience has become merged with the author, and as such, represents new functions and attributes, distinct from a more conventional concept of authorship, in which the roles of audience and author are more separate. Read/Write and participatory culture, as defined by this study, is focused on collaboration, and includes the influences of D.I.Y. culture, Open-Source practices and the production of text by multiple authors. Multi-authorship presents a re-thinking of several concepts which support the notion of the individual author, since the focus of multi-authorship is not on attribution and ownership of a finished text, but on the continued malleability of a text. Modes of multi-authorship, demonstrated in the use of the pseudonyms Alan Smithee and Karen Eliot, represent declarative authors whose names signify multiple origins, whilst concurrently indicating a distinct body of work. The function of these names form an important context to this study, since primary research involves the construction of an experimental mode of multi-authorship utilising WikiMedia technology and the interaction of thirty nine participants, who are invited to create a body of work under the collective pseudonym Karen Karnak. The data generated by this experiment is analysed using aspects of Michel Foucault's author-function to identify and determine power structures inherent in the WikiMedia context. The interplay of power structures, including concepts such as identity, ownership and the body of work, affect the resulting mode of authorship and contribute to the construction of Karen Karnak, suggesting further areas of research into the emerging multi-author
Apostolic Function and Mission
No full text This is the address given by Alan R Johnson, an alumnus of OCMS, to inaugurate the J. Philip Hogan Chair of World Mission. The Hogan chair represents a connection between Assemblies of God World Missions and the Assemblies of God Theological Seminary where in a proactive and catalytic fashion the process of engaging with subjects of missiological importance can be undertaken. The author argues that thinking about missions is a communal activity that requires continual reflection. </jats:p
Who Let the Secrets Out? Overconfidence and the Disclosure of Proprietary Information.
No full textThis dissertation investigates how CEO overconfidence is associated with the disclosure of proprietary information. I use characteristics of research and development activities (R&D;) and capital investments (CAPX) to examine within-firm variation in proprietary disclosure costs. After verifying that narrative disclosures about R&D; have higher levels of proprietary disclosure costs than those about CAPX, I predict that overconfident executives underestimate the costs of disclosing proprietary information, leading to higher proprietary disclosure. Consistent with this prediction, I find that overconfident CEOs disclose significantly more about R&D;, but not more about CAPX. Further, these CEOs increase the disclosure of distinctly proprietary R&D; information (i.e., about current and future investments) significantly more than less proprietary R&D; information (i.e., about historical investments). The results suggest the findings are not due to endogenous firm-CEO matching or overconfident CEOs selecting systematically different investment levels.</p
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