2,183 research outputs found
Zoonotic potential of Giardia duodenalis and Cryptosporidium spp. and prevalence of intestinal parasites in young dogs from different populations on Prince Edward Island, Canada
No full textThe prevalence of Giardia duodenalis, Cryptosporidium spp. and other intestinal parasites was determined in dogs <1 year old from Prince Edward Island, Canada. Fecal samples were collected from the local animal shelter (n=62), private veterinary clinics (n=78) and a pet store (n=69). Intestinal parasites isolated included G. duodenalis, Cryptosporidium spp., Toxocara canis, Isospora spp. and Uncinaria stenocephala. To estimate the zoonotic risk associated with these infections, genotypes of G. duodenalis and Cryptosporidium spp. were determined using 16S rRNA and Hsp70 gene sequencing, respectively. Dogs from the pet store had the highest prevalence of intestinal parasites (78%, 95% CI: 68-88%), followed by the private veterinary clinics (49%, 95% CI: 37-60%), and the local animal shelter (34%, 95% CI: 22-46%). The majority G. duodenalis belonged to host-adapted assemblages D (47%, 95% CI: 31-64%) and C (26%, 95% CI: 13-43%), respectively. Zoonotic assemblages A and B were isolated alone or in mixed infections from 16% (95% CI: 6-31%) of G. duodenalis-positive dogs. All Cryptosporidium spp. were the host-adapted C. canis. While host-adapted, non-zoonotic G. duodenalis genotypes were more common, the presence of G. duodenalis assemblages A and B, T. canis, and U. stenocephala suggests that these dogs may present a zoonotic risk. The zoonotic risk from Cryptosporidium-infected dogs was minimal.Fabienne D. Uehlinger, Spencer J. Greenwood, J. Trenton McClure, Gary Conboy, Ryan O’Handley, Herman W. Barkem
Spread spectrum communications emulator design
No full textIssued as R & D status reports [nos. 1-4], Contract funds status reports [nos. 1-8], and Final report, Project no. E-21-T12Final report has author: Gary J. SaulnierFinal report has title: Spread spectrum communications emulator desig
Mood disorders in familial epilepsy: A test of shared etiology
No full textObjective: Mood disorders are the most common comorbid conditions in epilepsy but the cause remains unclear. One possible explanation is a shared genetic susceptibility to epilepsy and mood disorders. We tested this hypothesis by evaluating lifetime prevalence of mood disorders in relatives with and without epilepsy in families containing multiple individuals with epilepsy, and comparing the findings with rates from a general population sample.
Methods: The Composite International Diagnostic Interview was administered to 192 individuals from 60 families, including 110 participants with epilepsy of unknown cause (50 focal epilepsy [FE], 42 generalized epilepsy [GE], 6 FE and GE, 12 unclassifiable) and 82 relatives without epilepsy (RWOE). Odds ratios (ORs) for lifetime prevalence of mood disorders in participants with versus without epilepsy were computed through logistic regression, using generalized estimation equations to account for familial clustering. Standardized prevalence ratios (SPRs) were used to compare prevalence in family members with general population rates.
Results: Compared with RWOE, ORs for mood disorders were significantly increased in participants with FE (OR = 2.4, 95% confidence interval [CI] = 1.1 - 5.2) but not in those with GE (OR = 1.0, 95% CI = 0.4 - 2.2). In addition, prevalence of mood disorders was increased in individuals with epilepsy who had ≥1 relative with FE. Compared with general population rates, mood disorders were significantly increased in individuals with FE but not in those with GE. Rates were also increased in RWOE, but not significantly so (SPR = 1.4, P = 0.14).
Significance: These findings are consistent with the hypothesis of shared genetic susceptibility to epilepsy and mood disorders, but suggest (1) the effect may be restricted to FE, and (2) the shared genetic effect on risk of mood disorders and epilepsy may be restricted to individuals with epilepsy, that is, to those in whom the genetic risk for epilepsy is “penetrant.”Peer reviewedThis is the accepted version of the following article: Insel BJ, Ottman R, Heiman GA. Mood disorders in familial epilepsy: A test of shared etiology. Epilepsia. 2018;00:1–9. https://doi.org/10.1111/epi.13985, which has been published in the Early View form at http://onlinelibrary.wiley.com/doi/10.1111/epi.13985/full. This article may be used for non-commercial purposes in accordance with the Wiley Self-Archiving Policy [https://authorservices.wiley.com/author-resources/Journal-Authors/licensing-open-access/open-access/self-archiving.html]
Exploratory radiomic features from integrated 18F-fluorodeoxyglucose positron emission tomography/magnetic resonance imaging are associated with contemporaneous metastases in oesophageal/gastroesophageal cancer
No full textPurpose: To determine if 18F-fluorodeoxyglucose positron emission tomography/magnetic resonance imaging (18F-FDG PET/MRI) features are associated with contemporaneous metastases in patients with oesophageal/gastroesophageal cancer.
Methods: Following IRB approval and informed consent, patients underwent a staging PET/MRI following 18F-FDG injection (326±28 MBq) and 156 ± 23 minutes uptake time. First- order histogram and second-order grey level co-occurrence matrix features were computed for PET standardized uptake value (SUV) and MRI T1-W, T2-W, diffusion weighted (DWI) and apparent diffusion coefficient (ADC) images for the whole tumour volume. K-means clustering assessed the correlation of feature-pairs with metastases. Multivariate analysis of variance (MANOVA) was performed to assess the statistical separability of the groups identified by feature-pairs. Sensitivity (SN), specificity (SP), positive predictive value (PPV), negative predictive value (NPV), and accuracy (ACC) were calculated for these features and compared with SUVmax, ADCmean and maximum diameter alone for predicting contemporaneous metastases.
Results: 20 patients (18 males, 2 female; median 67 years, range: 52-86) comprised the final study cohort; 10 patients had metastases. Lower second-order SUV entropy combined with higher second-order ADC entropy were the best feature-pair for discriminating metastatic patients, MANOVA p-value <0.001 (SN=80%, SP=80%, PPV=80%, NPV=80%, ACC=80%). SUVmax (SN=30%, SP=80%, PPV=60%, NPV=53%, ACC=55%), ADCmean (SN = 20%, SP = 70%, PPV = 40%, NPV = 47%, ACC = 45%) and tumour maximum diameter (SN=10%, SP=90%, PPV=50%, NPV=50%, ACC=50%) had poorer sensitivity and accuracy.
Conclusion: High ADC entropy combined with low SUV entropy is associated with a higher prevalence of metastases and a promising initial signature for future study
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'A daughter come home?': the travel writings of Colleen J. McElroy
No full textGas volume fraction and velocity profiles: vertical and inclined bubbly air-water flows
No full textUpward inclined gas-liquid flows are frequently encountered in the oil industry and data relating to the local gas volume fraction distribution and the local gas velocity distribution is important, for example, in pressure gradient prediction and in modeling oil well 'blowouts'. In this paper measurements are presented of the local gas volume fraction distribution and the local axial gas velocity distribution which were taken in bubbly air-water flows in an 80 mm diameter pipe which was inclined at angles of 0°, 15° and 30° to the vertical. Qualitative arguments are presented to explain the influence of the liquid superficial velocity on the local gas volume fraction distribution in inclined flow and also to explain the very high axial gas velocities observed towards the upper side of the inclined pipe
How "Chicagoan" are Gary Becker's Economic Models of Marriage?
No full textThis paper describes Gary Becker’s theoretical models of marriage. At the micro-level, these are all rational choice models. At the market level, Becker offers two major types of models: partial equilibrium models based on Price Theory as taught by Marshall and Friedman and optimal sorting models based on optimal assignment models. The paper examines some of the possible intellectual influences on Becker’s theory of marriage, compares Becker’s research on marriage with that of some scholars interested in intra-marriage distribution, and documents that Becker’s students at Chicago were more interested in Becker’s Friedmanian models of marriage than in his optimal assignment models.
The University of Utah College of Law Introduces Its 1970 Graduating Class
No full textPhotographs and profiles of 90 graduates: Jack B. Ames, David Paul Brown, Thomas C. Anderson, Richard Garrett Brown, Gary E. Atkin, Leonard Wesley Burningham, Jeffery Ralph Atkin, W. Clark Burt, Fred Keith Biesinger, Monte B. Carlson, James D. Caulfield, Douglas K. Cook, John CHipman, Dale J. Craft, Richard K. Circuit, Ralph D. Crockett, C. Edward Clark, Nick J. Colessides, Thomas N. Crowther, Jerry Wesley Dearinger, Duane A. Erickson, Jay L. DePew, Elmayah Doezie, Ronald K. Fielding, Tim Dalton Dunn, Tom Forsgren, Peter Mark Ennenga, Arnold Ira Freedland, Donald Jay Gamble, Douglas R. Haddock, Kem Crosby Gardner, Darwin C. Hansen, Brent James Giauque, Timothy R. Hanson, Dennis A. Gladwell, Richard Roy Harrington, Robert Goicoechea, Harold A. Hintze, Gary R. Howe, Marlyn Jensen, Bruce E. Humberstone, Alan K. Jeppesen, Hollis S. Hunt, James B. Kelly, Michael M. Hunter, Grant S. Kesler, R. Dennis Ickes, Joseph Douglas Kinateder, Phillip Robert Knight, Larry V. Lunt, Mills B. Lane III, Robert D. Maack, Michael T. Lowe, Michael J. Mazuran, Harry Earnest McCoy II, Edward T. McDonough, Gayle McKeachnie, Francis J. Nielson, Gary L. Montgomery, Willard Ezra Nyman III, Roy B. Moore, John D. Pearce, Myrna Mae Nebeker, Steven Howard Pond, Robert Lee Neeley, Gregory H. Pratt, Phillip G. Quigley, Glen Lee Rudd, Reid Russell, David P. Rhode, Neil R. Sabin, Raymond Lesley Ridge, Robert Lynn Sheperd, Clyde A. Romney, Lawrence J. Slade, John B. Squires, Margaret S. Taylor, Ronald S. Staten, Jack L. Tedrow, Harold Stephens, Dean P. Vernon, E. Keith Stott, Jr., Lance A. Wald, Arthur J. Swindle, David P. White, H. Mifflin Williams III, James W. Young, Kenton W. Willis, Richard Dobbs Young, H. Ross Workman
RRS James Cook Cruise JC064, 10 Sep - 09 Oct 2011. RAPID moorings cruise report
No full textThis cruise report covers scientific operations conducted during RRS James Cook Cruise JC064. Cruise JC064, departed from Falmouth on Thursday 1st September 2011 arriving Santa Cruz de Tenerife Saturday 10th September to pick up extra members of the scientific party and arriving again in Santa Cruz on the 9th October. The purpose of the cruise was the refurbishment of an array of moorings on the mid-Atlantic Ridge and off the Moroccan Coast at a nominal latitude of 26.5°N. The moorings are part of a purposeful Atlantic wide mooring array for monitoring the Atlantic Meridional Overturning Circulation and Heat Flux. The array is a joint UK/US programme and is known as the RAPID-WATCH/MOCHA array. Information and data from the project can be found on the web site hosted by the National Oceanography Centre Southampton http://www.noc.soton.ac.uk/rapidmoc and also from the British Oceanographic Data Centre http://www.bodc.ac.uk.
The array as deployed in 2011-2012 consists of a total of 17 moorings, 16 landers and a single inverted echo sounder. The moorings are primarily instrumented with self logging instruments measuring conductivity, temperature and pressure. Direct measurements of currents are made in the shallow and deep western boundary currents. The bottom landers are instrumented with bottom pressure recorders (also known as tide gauges), measuring the weight of water above the instrument.
The RAPID naming convention for moorings is Western Boundary (WB), Eastern Boundary (EB) and Mid‐Atlantic Ridge (MAR) indicating the general sub‐regions of the array. Numbering increments from west to east. An L in the name indicates a bottom lander, M indicates a mini‐mooring with only one instrument, H indicates a mooring on the continental slope. During JC064 we recovered: MAR0, MAR1L4, MAR1, MAR2, MAR3, MAR3L4, EB1, EB1L7, EBHi, EBH1, EBH1L7, EBH2, EBH3, EBH4, EBP2, EBH5, EBM5. We did not recover EBM1, EBM4, EBM6, EBH1 and MAR3. We deployed: MAR0, MAR1L7, MAR1, MAR2, MAR3, MAR3L6, EB1, EB1L7, EBHi, EBH1, EBH1L8, EBH2, EBH3, EBH4, EBP2, EBH5. A sediment trap mooring NOGST was also recovered and redeployed for the Ocean Biogeochemistry and Ecosystems Group at the NOCS.
CTD stations were conducted at convenient times throughout the cruise for purposes of providing pre and post deployment calibrations for mooring instrumentation and for testing mooring releases prior to deployment.
Shipboard underway measurements were systematically logged, processed and calibrated, including: waves (spectra of energy and significant wave height), surface meteorology (air pressure, temperature, wind speed and direction and radiation (total incident and photosynthetically active), 6m‐depth sea temperatures and salinities, water depth, navigation (differential GPS measurements feeding two independent and different receivers, heading, pitch and roll, gyro heading and ships speed relative to the water using an electromagnetic log). Water velocity profiles from 15m to approximately 800m/300m depth were obtained using a ship mounted 75/150 kHz acoustic Doppler current profiler. Seawater samples from CTD stations and of the sea-surface were obtained for calibration and analysed on a salinometer referencing these samples against standard sea water. For velocity data (wind and currents) measured relative to the ship considerable effort was made to obtain the best possible earth referenced velocities.
Seven APEX argo floats supplied by the Met Office were deployed at preassigned locations, filling gaps in the network
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