2,759 research outputs found
Renal CLC-K chloride channels heterologously coexpressed with barttin are specifically affected by 2-(p-chlorophenoxy)propionic acid derivatives
No full text
Application of the IS-MP-IA model to the German economy and policy implications
No full textExtending the IS-MP-IA model developed by Romer (2000) and applying the GARCH (Engle, 1982, 2001) methodology, the author finds that equilibrium GDP in Germany is positively affected by stock market performance and real exchange rate appreciation, and negatively influenced by the expected inflation rate, the government deficit/GDP ratio, and the U.S. federal funds rate. The relatively low deficit/GDP ratio of 1.83% in 2003 indicates that its fiscal condition was healthy. However, some other EU members may need to exercise fiscal discipline. Because real appreciation has a positive impact on output, a stronger euro may not be a concern for Germany but may be worried by those EU member nations which depend upon exports to stimulate their economies.
The effect of a daytime nap on priming and recognition tasks in preschool children.
No full textAbstract
STUDY OBJECTIVES:
The beneficial effect of sleep on memory consolidation is widely accepted in the adult population and has recently been shown in children. However, the few available data almost exclusively refer to school-aged children. Here we explore the effect of a daytime nap on memory consolidation in a sample of preschool children.
DESIGN:
Subjects performed both a figures recognition task and a priming task, in order to differentiate effects on explicit and implicit memory.
SETTING:
Nursery school.
PARTICIPANTS:
Twenty-three children (mean age: 52.6 ± 8 mo; 13 males) participated in the study.
INTERVENTION:
After a study phase in which children had to name 40 pictures of objects and animals, each subject either took an actigraphically monitored nap or stayed awake. At retest, children were administered both an implicit and an explicit memory task.
MEASUREMENTS AND RESULTS:
The implicit memory task consisted of naming 40 pictures presented at eight ascending levels of spatial filtering. The explicit memory task consisted of judging 40 pictures as old or new. The number of correct answers at the explicit recognition task was significantly higher in the nap compared to the wake condition, whereas priming effects did not differ between conditions.
CONCLUSIONS:
A positive role of sleep in explicit memory consolidation, similar to the one observed in the adult, was detected in our sample of preschool children. In contrast, our data suggest that implicit perceptual learning, involved in priming tasks, does not benefit from sleep
Winning redefined, a new brand positioning for MP Motorsport
No full textMP Motorsport is a talent educating race team participating in the classes below the Formula 1. The problem with the lower classes and therefore MP Motorsport as well is that these classes don’t get much attention and exposure. As a company run by people with passion the branding and positioning is more something that naturally emerged from this passion rather than a series of conscious decisions. This makes it fragile. A more conscious strategy and vision on how MP Motorsport needs to be branded and positioned against their competition that is more than “look how cool racing is” is needed to become more attractive for sponsoring. This report describes the process from analysis to finding the right positioning and an advise for a new brand identity and an implementation plan to help becoming more attractive for sponsoring goals. The analysis done with employees showed a unique characteristic that will help the team to position themselves against the competition; the family atmosphere. This atmosphere is what also characterises their contradictory personality. This personality is on one hand leading and ambitious and on the other hand modest and involved. Competition and stakeholder analysis have been performed to find the right combination of being unique to the competition, desirable for the stakeholders (the fans and sponsors) and builds upon the core strengths of the company. Then using the brand key model, a positioning is made with the essence: Be your best self. The belief, “in everyone hides a talent” and values like “everyone is equal” and “together we succeed” combined with the essence and the positioning resulted in a brand story that describes the feeling MP Motorsport wants to communicate. To manifestate the brand, an advise has been set up for a tone of voice and tone of image. Wrapped in a concept called “winning redefined” this advise is part of the whole implementation plan that should lead the way for the team to implement the newly created brand in short and long term actions. In 3 phases MP Motorsport is advised to start with a clear brand introduction to the target groups Gen Z and potential sponsors. The next phase revolves around creating a community to attract both Gen Z talents and subsequently sponsors to interact with the team and each other. Finally the last phase is long term focused and aims for sustainable growth. In this phase the community is established and can expect various opportunities to discover and develop a whole range of talents, sponsors and gen z are connected to each other via MP Motorsport and the team is able to finance the lower classes without the pressure of the money drivers bring along.Strategic Product Desig
Plasma chromogranin A response to octreotide test: prognostic value for clinical outcome in endocrine digestive tumors
No full textThe EML4-ALK transcript but not the fusion protein can be expressed in reactive and neoplastic lymphoid tissues.
No full text
Molecular determinants of differential pore blocking of kidney CLC-K chloride channels
No full textThe highly homologous Cl(-) channels CLC-Ka and CLC-Kb are important for water and salt conservation in the kidney and for the production of endolymph in the inner ear. Mutations in CLC-Kb lead to Bartter's syndrome and mutations in the small CLC-K subunit barttin lead to Bartter's syndrome and deafness. Here we show that CLC-Ka is blocked by the recently identified blocker 2-(p-chlorophenoxy)-3-phenylpropionic acid of the rat channel CLC-K1 with an apparent K(D) approximately 80 microM. We also found that DIDS (4,4'-diisothiocyanatostilbene-2,2'-disulphonic acid), a generic Cl(-) channel blocker, inhibits CLC-Ka (K(D) approximately 90 microM). Surprisingly, the highly homologous channel CLC-Kb is fivefold to sixfold less sensitive to both compounds. Guided by the crystal structure of bacterial CLC proteins, we identify two amino acids, N68/D68 and G72/E72, in CLC-Ka and CLC-Kb, respectively, that are responsible for the differential drug sensitivity. Both residues expose their side chains in the extracellular pore mouth, delineating the probable drug binding site. These novel CLC-K channel blockers are promising lead compounds for the development of new diuretic drugs
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