64 research outputs found
sj-pdf-1-scm-10.1177_00369330221099619 - Supplemental material for Management of stage II seminoma: a contemporary UK perspective
No full textSupplemental material, sj-pdf-1-scm-10.1177_00369330221099619 for Management of stage II seminoma: a contemporary UK perspective by Constantine Alifrangis, David L. Nicol, Jonathan Shamash and Prabhakar Rajan on behalf of the National Cancer Research Institute Teenage and Young Adult and Germ Cell Tumour Research Group in Scottish Medical Journal</p
Pfui – Pish, Pshaw / Prr, Saskia Olde Wolbers, 2017 two channel video HD 20 min, PCAI
No full textPfui – Pish, Pshaw / Prr, deals with the urgent business of toxic waste management and gives voice to Mr Theodosis Alifrangis, the longest-serving worker of a Greek oil spill response company.
The fictional script, loosely based on Alifrangis’ anekdotes, is from an oil spill responder’s point of view and reveals his superstitious reason for filming; "Xematiasma", the Greek oil and water divination, where his camera wards off the evil eye whilst tending to major emergencies on a daily basis.
He expands into further musings around matter and spirit, ancient rituals for cleansing the sea, his love for shipwrecks, recollections of heroic acts against the mundane everyday reality of cleaning heavy oils from the sea’s surface, until narrative time seemingly starts reversing, playing with ideas of toxic waste and permanence.
The two screen work features an eclectic sample of Alifrangis’ prolific VHS archive, unofficially filmed over 40 years on his camcorder, alongside imagery created in Olde Wolbers’ studio, where model sets of cruise ship interiors, ferromagnetic mussels and molecular structures are covered in iridescently coloured dripping oils and filmed in tanks.
It also features sonar imaging attempts around the unsalvageable Sea Diamond, a cruise ship in Santorini that has commanded Alifrangis’ daily care for the last 10 years, filmed by Olde Wolbers in collaboration with Alifrangis
Sonar is a technology used in medicine and marine archaeology and is here innovatively used in an art context to visualise pollution.
The title derives from a DH Lawrence letter in which the author abandoned language to express an onomatopoeic anger.
The work was commissioned by Polyeco’s Contemporary Art Initiative (PCAI) which raises environmental awareness through an art program curated by Nadia Agyropoulou.
It was co-commissioned by Invisible Dust who work with leading artists and scientists, to produce works of contemporary art exploring climate change and the environment
Genetics of gestational trophoblastic neoplasia: an update for the clinician
No full text Gestational trophoblastic disease is a spectrum of disorders ranging from premalignant hydatidiform moles through to malignant invasive moles, choriocarcinoma and rare placental site trophoblastic tumor. The latter are often collectively referred to as gestational trophoblastic tumors or neoplasia (GTN). Although most women can expect to be cured of their disease, many interesting questions arise in the management of gestational trophoblastic disease. Current issues pertain to diagnosis of GTN, predicting progression from hydatidiform moles to GTN and the emergence of drug resistance in GTN. Our understanding of the genetics of GTN has helped us answer some of these questions but many remain unresolved. This article seeks to address recent advances in the genetics of GTN in relation to diagnosis, etiology, prognosis and treatment. </jats:p
Letter to the Editor: Central nervous system relapse rate and dose intensification in poor risk metastatic germ cell tumours—A comment on: ‘Patterns of relapse in poor prognosis germ cell tumours in the GETUG-13 trial: Implications for the assessment of brain metastases.’ by Loriot and colleagues
No full textDose intense chemotherapy in the management of poor prognosis and relapsed testicular cancer: experiences and controversies
No full textINTRODUCTION: The treatment of poor prognosis chemotherapy naïve or relapsed testicular cancer is challenging. In poor prognosis treatment naïve disease, the outlook for patients with standard approaches utilising three weekly cisplatin based regimens, most commonly bleomycin, etoposide and cisplatin (BEP) is suboptimal, and one can expect more than half of patients to relapse or progress and need salvage treatment. Recent randomised studies have lent weight to the use of dose intensified treatments in these selected patient groups. In relapsed testicular cancer, post platinum based chemotherapy controversy exists as to the optimum relapse regimen as significant cure rates can be expected by re-treating with both conventional dose and high dose or dose intense regimens. AREAS COVERED: This review seeks to outline the evidence for alternative approaches beyond standard three weekly cisplatin based regimens in poor risk metastatic disease. It also explores the evidence available for selection between conventional dose and high dose strategies on relapse. EXPERT COMMENTARY: An overview of the data is presented to support personalising therapy selection in both poor risk and relapsed metastatic germ cell tumors
Pfui – Pish, Pshaw / Prr (excerpt) 2017
No full text(Two channel video HD 20 min, PCAI)
Deals with the urgent business of toxic waste management. The work is loosely based on interviews with mr Theodosis Alifrangis, the longest-serving employee of Polyeco/EPE, a Greek toxic waste / oil spill response company.
For the last ten years Mr Theodosis has been stationed at the wreck of a cruise ship, which sunk in the deep waters of Santorini’s port. He has become the ship’s conscientious guardian, tending to the slow release of petrol and protecting the surrounding waters and marine life.
An eclectic sample of Mr Theodosis’ prolific VHS archive, unofficially filmed on his camcorder whilst on various call outs since the 1980’s, is presented here alongside footage created in Olde Wolbers’ studio, where model sets of cruise ship interiors, ferromagnetic mussels and molecular structures are covered in iridescently coloured dripping oils and filmed in tanks.
The work also features footage of sonar imaging attempts around the elusive, unsalvageable cruise ship, filmed in 2016 by both Olde Wolbers and Alifrangis on location in Santorini.
The fictional script is from an oil spill responder’s point of view and reveals his superstitious reason for filming; "Xematiasma", the Greek oil and water divination, where his camera wards off the evil eye whilst tending to major emergencies on a daily basis.
He expands into further musings around matter and spirit, ancient rituals for cleansing the sea, his love for shipwrecks and the mundane everyday reality of cleaning. Until narrative time seemingly starts reversing, playing with ideas of waste and permanence.
This fictional work’s title derives from a DH Lawrence letter in which the author abandoned language to express an onomatopoeic anger
A patient‐centric pathway for testicular cancer – A multicentre study investigating the uptake of semen cryopreservation and impact on treatment
No full textBackground: The option of semen cryopreservation following a diagnosis of testicular cancer shows a variable uptake with the option to cryopreserve before surgery often dependent on the preference of the treating clinician and the fertility laboratory resources available. Objectives: To assess whether the introduction of a patient-centric pathway for managing suspected testicular cancer increases the uptake of semen cryopreservation and the impact of this on surgical waiting times. Materials and methods: A multicentre retrospective analysis of patients treated as part of a patient-centric pathway was conducted for suspected testicular cancer at two specialist centres within a one-stop testicular clinic. Clinical information, including semen cryopreservation acceptance rate, time intervals to surgery and CT scan, TNM stage, histology and age, was recorded from an institutional database. Results: Eighty nine patients (median age: 34 years (range: 14–89)) underwent orchidectomy for suspected testicular cancer over a 15-month period after the introduction of a patient-centric testicular cancer pathway at two UK centres. The overall uptake of semen cryopreservation was 68.5% (n = 61) with all men under the age of 33 years accepting this option. A microdissection oncoTESE was performed in 9/61 (14.8%) patients who attempted cryopreservation but were found to be azoospermic. Pre-operative CT imaging was completed for 85.4% of patients, and the median time from initial outpatient consultation to orchidectomy was 9 days. Discussion and conclusions: A patient-centric pathway ensures that the uptake of semen cryopreservation remains high particularly for those men within the common age for paternity. It also identifies men who may benefit from microdissection oncoTESE for complex cases such as tumours in solitary testicles, bilateral tumours or an atrophic contralateral testicle as well as those diagnosed with de novo azoospermia. The additional time taken for semen cryopreservation to be performed did not significantly delay orchidectomy or influence the decisions for adjuvant treatment.</p
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