94 research outputs found
Informatiesysteem Goederenstromen Europa (ISG)
No full textVeranderingen in de infrastructuur in Europa zullen hun invloed doen gelden op het toekomstige goederenvervoer en daarmee op de distributiepositie van Nederland. Dit rapport beschrijft een informatiesysteem waarmee het inzicht in het effect van dergelijke veranderingen in de infrastructuur kan worden verdiept. Het informatiesysteem bestaat in essentie uit een geïntegreerd Europees netwerk waarin de belangrijkste vervoerwijzen (weg, water, spoor en short-sea) zijn opgenomen. Op basis van factoren als reistijden, tarieven en eigenschappen van de te vervoeren goederensoort kunnen routes en vervoerwijze worden berekend. Het informatiesysteem bevat voorts een hoeveelheid algemene gegevens betrekking hebbende op het goederenvervoer in Europa, afkomstig van het Europese bureau voor statistiek Eurostat. Implementatie heeft plaatsgevonden in een Geografisch Informatiesysteem (GIS).Transport and PlanningCivil Engineering and Geoscience
Peripherally-driven myeloid NFkB and IFN/ISG responses predict malignancy risk, survival, and immunotherapy regime in ovarian cancer
No full textBACKGROUND: Tumors can influence peripheral immune macroenvironment, thereby creating opportunities for non-invasive serum/plasma immunobiomarkers for immunostratification and immunotherapy designing. However, current approaches for immunobiomarkers' detection are largely quantitative, which is unreliable for assessing functional peripheral immunodynamics of patients with cancer. Hence, we aimed to design a functional biomarker modality for capturing peripheral immune signaling in patients with cancer for reliable immunostratification. METHODS: We used a data-driven in silico framework, integrating existing tumor/blood bulk-RNAseq or single-cell (sc)RNAseq datasets of patients with cancer, to inform the design of an innovative serum-screening modality, that is, serum-functional immunodynamic status (sFIS) assay. Next, we pursued proof-of-concept analyses via multiparametric serum profiling of patients with ovarian cancer (OV) with sFIS assay combined with Luminex (cytokines/soluble immune checkpoints), CA125-antigen detection, and whole-blood immune cell counts. Here, sFIS assay's ability to determine survival benefit or malignancy risk was validated in a discovery (n=32) and/or validation (n=699) patient cohorts. Lastly, we used an orthotopic murine metastatic OV model, with anti-OV therapy selection via in silico drug-target screening and murine serum screening via sFIS assay, to assess suitable in vivo immunotherapy options. RESULTS: In silico data-driven framework predicted that peripheral immunodynamics of patients with cancer might be best captured via analyzing myeloid nuclear factor kappa-light-chain enhancer of activated B cells (NFκB) signaling and interferon-stimulated genes' (ISG) responses. This helped in conceptualization of an 'in sitro' (in vitro+in situ) sFIS assay, where human myeloid cells were exposed to patients' serum in vitro, to assess serum-induced (si)-NFκB or interferon (IFN)/ISG responses (as active signaling reporter activity) within them, thereby 'mimicking' patients' in situ immunodynamic status. Multiparametric serum profiling of patients with OV established that sFIS assay can: decode peripheral immunology (by indicating higher enrichment of si-NFκB over si-IFN/ISG responses), estimate survival trends (si-NFκB or si-IFN/ISG responses associating with negative or positive prognosis, respectively), and coestimate malignancy risk (relative to benign/borderline ovarian lesions). Biologically, we documented dominance of pro-tumorigenic, myeloid si-NFκB responseHIGHsi-IFN/ISG responseLOW inflammation in periphery of patients with OV. Finally, in an orthotopic murine metastatic OV model, sFIS assay predicted the higher capacity of chemo-immunotherapy (paclitaxel-carboplatin plus anti-TNF antibody combination) in achieving a pro-immunogenic peripheral milieu (si-IFN/ISG responseHIGHsi-NFκB responseLOW), which aligned with high antitumor efficacy. CONCLUSIONS: We established sFIS assay as a novel biomarker resource for serum screening in patients with OV to evaluate peripheral immunodynamics, patient survival trends and malignancy risk, and to design preclinical chemo-immunotherapy strategies.sponsorship: This study is supported by Research Foundation Flanders (FWO) (Fundamental Research Grant, G0B4620N to ADG; G0B4716N to DT; Excellence of Science/EOS grant, 30837538, for 'DECODE' consortium, for ADG, PA), KU Leuven (C1 grant, C14/19/098, C3 grant, C3/21/037, and POR award funds, POR/16/040 to ADG; C24/15/037 to DT), Kom op Tegen Kanker (Stand Up To Cancer, the Flemish Cancer Society) (KOTK/2018/11509/1 to ADG and PA; KOTK/2016/10728/2603 to AC, DT, and IV; KOTK/2019/11955/1 to AC, ADG, IV, and 11758 to AK), Amgen Chair for Therapeutic Advances in Ovarian Cancer (2017/LUF/00069 to IV), Vriendtjes Tegen Kanker (2016_LUF_00078 to IV) and VLIR-UOS (iBOF grant, iBOF/21/048, for 'MIMICRY' consortium to ADG and ST). IsVa is supported by FWO-SB PhD Fellowship (1S06821N). CL was supported by the Linbury Trust Grant LIN2600. DMB is supported by KU Leuven's Postdoctoral mandate grant (PDMT1/21/032), and the Belgian Federation against Cancer grant numbers 2018-127 and 2016-133 and by a grant from Fondation Roi-Baudouin to ST. ST and DT are further supported by a Senior Clinical Investigator award of FWO. (Research Foundation Flanders (FWO)|G0B4620N, Research Foundation Flanders (FWO)|G0B4716N, Research Foundation Flanders (FWO)|30837538, KU Leuven|C14/19/098, KU Leuven|C3/21/037, KU Leuven|POR/16/040, KU Leuven|C24/15/037, KU Leuven|PDMT1/21/032, Kom op Tegen Kanker (Stand Up To Cancer, the Flemish Cancer Society)|KOTK/2018/11509/1, Kom op Tegen Kanker (Stand Up To Cancer, the Flemish Cancer Society)|KOTK/2016/10728/2603, Kom op Tegen Kanker (Stand Up To Cancer, the Flemish Cancer Society)|KOTK/2019/11955/1, Kom op Tegen Kanker (Stand Up To Cancer, the Flemish Cancer Society)|11758, Amgen Chair for Therapeutic Advances in Ovarian Cancer|2017/LUF/00069, Vriendtjes Tegen Kanker|2016_LUF_00078, VLIR-UOS (iBOF grant)|iBOF/21/048, FWO-SB PhD Fellowship|1S06821N, Linbury Trust|LIN2600, Belgian Federation against Cancer|2018-127, Belgian Federation against Cancer|2016-133, Fondation Roi-Baudouin)status: Publishe
Pattern based processing of XPath queries
No full textAs the popularity of areas including document storage and
distributed systems continues to grow, the demand for high
performance XML databases is increasingly evident. This
has led to a number of research eorts aimed at exploiting
the maturity of relational database systems in order to in-
crease XML query performance. In our approach, we use an
index structure based on a metamodel for XML databases
combined with relational database technology to facilitate
fast access to XML document elements. The query process
involves transforming XPath expressions to SQL which can
be executed over our optimised query engine. As there are
many dierent types of XPath queries, varying processing
logic may be applied to boost performance not only to indi-
vidual XPath axes, but across multiple axes simultaneously.
This paper describes a pattern based approach to XPath
query processing, which permits the execution of a group of
XPath location steps in parallel
Designing role-based view for object-relational databases
No full textIn a federated database system, a view mechanism is crucial since it is used to define exportable subsets of data ; to perform a virtual restructuring d ataset; and to construct the integrated schema. The view service in federated databa se systems must be capable of retaining as much semantic information as possible. The object-oriented ( 0 - 0 ) model was considered the suitable canonical data model since it meets the original criteria for canonical model selection. However, with the emergence of stronger object-relational (0 -R ) model, the re is a clear argument for using an 0 - R canonical model in the federation. Hence, research should now focus on th e development of semantically powerful view mechanism for th e newer model. Meanwhile, the availability of real 0 -R technologies offers researchers the opportunity to develop different forms of view mechanisms.
The concept of roles has been widely studied in 0 - 0 modelling and development. The role model represents some characteristics that the traditional 0-0 model lacked, such as object migration, multiple occurrences and context-dependent access. While many forms of 0-0 views were designed for the 0-0 canonical model, one option was to extend the 0-0 model to incorporate a role model. In a role model, the real entity is modelled in the form of a role rather than an object. An object represents the permanent properties of an entity is a root object; and an object represents the temporary properties of an entity is a role object.
The contribution of this research is to design a view system that employees the concept of roles for the 0 -R canonical model in a federated database system. In this thesis, an examination of the current 0 -R metamodel is provided first in order to provide an environment for recognising the roleview metadata and measuring the view performance; then a Roleview Definition Language (RDL) is introduced, along with the semantics for defining virtual classes and generating virtua l extents; finally, a working prototype is provided to prove th e role-based view system is implementable and the syntax is semantically correct
Introducing the Iguana Genome Project
No full textThe Iguana Genome Project is currently conducted in the frame of the Consortium for Iguana
Genome (CIG). The CIG is coordinated and led by the University Tor Vergata (Rome, Italy) and
at present is in partnership with the Malaysia Genome Institute, the Universiti Kebangsaan
Malaysia (UKM), and the University of Leeds (UK). The project aims to provide a genomic
perspective on the origins, evolution, and adaptation of Galápagos Iguanas, taking advantage
of latest advances in genomics and transcriptomics. Several questions will be tackled such as
the adaptation to diving, the origin and implications of depigmentation, the genetic base of
ecological requirements, and physiological and behavioral responses to the environment.
Additionally, the project uses a genomic approach to reconstruct the most recent
demographic history of specific populations and address the role of hybridization in guiding
the evolutionary processes in Galápagos species. Finally, the project also aims to provide
reference genomes for the conservation of threatened species.
The CIG has already produced genome data of Conolophus marthae (93X coverage),
Conolophus pallidus (10X coverage), and Amblyrhynchus cristatus (40 X coverage).
Conolophus subcristatus’ genome is currently being sequenced. RNAs have been processed
for transcriptome analysis for all Galápagos species.
The project aims to carry out the investigations within a phylogenetic framework, and so the
sequencing of the genomes of other genera of Iguanidae (Cyclura and Ctenosaura) is currently
programmed. The long term objective is to extend the investigation to the whole family
Iguanidae. For this reason, the participation of other partners is envisioned and welcome
Издательский бизнес Украины: аспекты становления и развития
No full textIn the article the author explores the origin, development and formation of publishing entrepreneurship during the times of independent Ukraine.У статі автор досліджує зародження, розвиток та становлення видавничого підприємництва часів незалежної України.В статье автор исследует зарождение, развитие и становление издательского предпринимательства во времена независимой Украины
Малый бизнес как ядро современной экономики
No full textIn the article the author explores the origin, development and formation of small business during the times of independent Ukraine.У статті автор досліджує зародження, розвиток та становлення малого підприємництва часів незалежної України.В статье автор исследует зарождение, развитие и становление малого предпринимательства во времена независимой Украины
Tangible and intangible elements of design for well-being in the home
No full textIssue The ISO/IEC Guide 71 states: "It is an important goal for the whole of society that all people, regardless of their age, size or ability, have access to the broadest range of systems". Considering housing as a system this paper asks if design of Australian housing generally takes the goal mentioned above into account and whether it is a sufficient goal both to address the desire of older Australians to remain living independently as they age and to support their well-being in the home. Approach The architect and author of this paper used 'an architecture of accommodation' approach in designing an award-winning house that would support independence of the occupants into old age. This house is used as a case-study to identify both 'tangible' and 'intangible' elements of the home that are seen to support independence. Further a limited post-occupancy evaluation was carried out as a public litmus test to indicate if the design approach taken was recognized by the general public. Results, discussion and practical implications Both tangible and intangible elements of design contribute to the independence and well-being of older people at home. However, two important guidelines on housing design for older people refer only to tangible elements of design. It is proposed that intangible elements of design, which make older people feel well, encourage self-esteem and support independence, are also critical in providing high quality housing for older people
Metadata queries for complex database systems
No full textFederated Database Management Systems (FDBS) are very complex. Component databases can be heterogeneous, autonomous and distributed, accounting for these different characteristics in building a FDBS is a difficult engineering problem. The Common Data Model (CDM) is what is used to represent the data in the FDBS. It must be semantically rich to correctly represent the data from diverse component databases which differ in structure, datamodel, semantics and content. In this research project we look at the complexity of the FDBS and examine which datamodel is most suited for th e CDM. A good metad a ta interface and query language is essential for th e CDM because merging component databases into the FDBS and maintaining and building the FDBS rely on a complete metadata interface and query language. In this research project we analyse the metadata interface and query language of the Object-Relational datamodel with a view to use it as the CDM. Distributed Component databases in a FDBS need to be merged in to the FDBS, current tools can not completely automate this process, we examine these problems and present a mobile solution
Методи вивчення термінів і терміносистем
No full textIn the article, the author proves that in the process of term analysis of the text and text analysis of the term, a whole set of methods of modern terminology is used. In particular, these are actual terminological methods of analyzing the structure and construction of term systems (as a result of establishing connections between identified terms), selection of term elements, dissection of combinations of terms; linguistic methods; logical methods of classification; methods of related and complex sciences and other scientific fields (methods of sociolinguistics, sociology, psycholinguistics), etcУ статті авторка доводить, що у процесі термінного аналізу тексту і текстового аналізу терміна застосовується цілий комплекс методів сучасного термінознавства. Зокрема – це власне термінознавчі методи аналізу структури і конструювання терміносистем (у результаті встановлення зв’язків між виявленими термінами), виділення терміноелементів, розчленування поєднань термінів; лінгвістичні методи; логічні методи класифікації; методи дотичних і комплексних наук та інших наукових галузей (методи соціолінгвістики, соціології, психолінгвістика) тощ
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