1,721,050 research outputs found
Variabilità circadiana della pressione arteriosa, ambulatory arterial stiffness index e trasporto transmembrana eritrocitaria di elettroni nei fratelli di diabetici tipo 1
No full textTrattamento short-term (1 mese) con Armolipid Plus nel dislipidemico soprappeso
No full textIntroduzione: Le dislipidemie sono un importante fattore di rischio cardiovascolare. Le raccomandazioni dell’ATP III suggeriscono valori <100 mg/dl di Colesterolemia LDL (LDL- Ch) nei soggetti ad elevato rischio cardiovascolare, inferiori a 130 nei soggetti a rischio moderato ed a 160 nelle persone a basso rischio. Urgono strategie valide di prevenzione primaria e secondaria.
Armolipid Plus è un nutraceutico contenente Policosanolo, Lievito rosso e Berberina con Acido folico, Coenzima Q10 e Astaxantina, che agisce riducendo il LDL-Ch ed incrementando possibilmente la Colesterolemia HDL (HDL-Ch).
Scopo: L’obiettivo dello studio è stato di valutare l’effetto di Armolipid Plus sui classici parametri lipidici (Colesterolo Totale (T-Ch), LDL-Ch, HDL-Ch, Trigliceridi (TG)), glicemia a digiuno, Pressione Arteriosa Sistolica (PAS), Pressione Arteriosa Diastolica (PAD), peso corporeo in soggetti dislipidemici in sovrappeso, senza modificare le loro abitudini alimentari ed il loro stile di vita.
Metodi: In 22 soggetti consecutivi (1 maschio e 21 femmine, età media 59.7±11.4, BMI 28.9±5.6) che avevano rifiutato la terapia con statine, abbiamo deciso di iniziare un trattamento alternativo con Armolipid Plus. Il protocollo osservazionale prevedeva un follow-up di due mesi.
Risultati: Abbiamo osservato una riduzione altamente significativa del livello medio di T-colesterolemia, LDL-colesterolemia e trigliceridemia, senza variazioni significative seppur decrementali di glicemia e BMI. La HDL-colesterolemia è aumentata, seppur in modo non significativo, inalterate PAS e PAD.
Conclusioni: L’Armolipid Plus si rivela un affidabile risorsa terapeutica prontamente efficace nella dislipidemia non trattata con statine di sintesi. Valuteremo nel follow-up gli effetti e la sostenibilità terapeutici
Leukocyte mitochondrial membrane potential in type 1 diabetes families
No full textBackground: Proper cellular function requires the maintenance of mitochondrial membrane potential (MMP) sustained by the electron transport chain. Mitochondrial dysfunction is believed to play a role in the development of diabetes and diabetic complications possibly because of the active generation of free radicals. Since MMP can be investigated in clinical settings using fluorescent probes and living whole blood cells, mitochondrial membrane alterations have been observed in some chronic disorders.
Materials and Methods: We have used the mitochondrial indicator 5,5’,6,6’-tetra chloro-1,1’,3,3’-tetraethylbenzimidazolyl-carbocyanine iodide (JC-1) in conjunction with flow cytometry to measure the MMP in peripheral blood granulocytes from type 1 diabetes (T1D) families (diabetic probands and non-diabetic siblings). The intracellular ROS levels and the respiratory burst activity were also measured.
Results: Leukocyte MMP was elevated in 20 T1D patients and their 20 non-diabetic siblings compared with 25 healthy subjects without family history of T1D. Fasting plasma glucose was the only correlate of MMP.
Conclusions: The flow cytometric finding of mitochondrial hyperpolarisation in circulating leukocytes suggests a functional synchronization across the mitochondrial network in T1D family members, even without frank diabetes. The functional implications of mitochondrial hyperpolarisation (probably different among different cells) will require extensive investigation
One-year follow-up of biologic correlates for arterial blood pressure in type 2 diabetes
No full textBackground: Previous results suggested that blood pressure
(BP) response to exercise was significantly correlated with
HbA1c levels in healthy normotensive non-diabetic control
subjects. Present investigation evaluated the biologic determinants
of arterial BP during one-year follow-up in patients with
type 2 diabetes (T2D).
Materials and methods: Cardiovascular risk factors were
assessed at baseline, 1, 3, 6, 9 and 12 months in 20 T2D (age
60 ± 5 year). Were measured: body mass index (BMI), waist to
hip ratio (WHR), mean BP, fasting plasma glucose (FPG),
HbA1c, plasma LDL cholesterol, folate and total homocysteine
(tHcy), urinary albumin excretion (UAE). Dietary habits were
estimated at each visit by administering a 2-day 24-h dietary
recall (24 HDR).
Results: BMI was 31 ± 5 kg/m2, WHR 0Æ97 ± 0Æ06, mean BP
98 ± 10 mmHg, FPG 159 ± 42 mg/dL, HbA1c 7Æ4 ± 1Æ2%, LDL
118 ± 31 mg/dL, folati 8Æ9 ± 6Æ6 ng/mL, tHcy 11Æ5 ± 3Æ4 lmol/
L. UAE ranged from 0 to 2957 lg/min (median 15Æ8). Multivariate
regression analysis of longitudinal data found the following
independent variables to be associated with MBP
(|r| = 0Æ54, P < 0Æ0001): HbA1c (t-value 5Æ24), folati (-2Æ84), and
LDL (2Æ21). Estimated daily intake of folic acid was
286 ± 129 lg/day significantly lower than Recommended Dietary
Allowance.
Conclusions: This study confirms in T2D previous observations
in healthy people. There is a significant positive correlation
between protein glycosylation and arterial BP.
Additional influential factors are plasma folate and LDL cholesterol.
These findings strengthen the need for maintaining
a strict metabolic control (glycosylation of matrix proteins affect artery compliance) and promoting an adequate dietary
intake of folate
Effects of calcitriol on the immune system: New possibilities in the treatment of glomerulonephritis
No full text1. 1,25-Dihydroxyvitamin D-3 (1,25(OH)(2)D-3), the hormonal form of vitamin D, is widely appreciated to play a central role in calcium and phosphate homeostasis. However, it is becoming increasingly clear that the sterol also play an important role in the regulation of cellular growth, haematopoietic tissues and the immune system, as well as in the modulation of hormone secretion by several endocrine glands. 2. In the present review, some of the mechanisms by which 1,25(OH)(2)D-3 regulates immune function are highlighted. Moreover, a number of studies on the effects of calcitriol in several experimental animal models of renal disease are reported, suggesting new possibilities in the therapy of glomerulonephritis
Severe hypotension during hemofiltration in an uremic patient with metabolic alkalosis
No full textWe describe a case of medication induced metabolic alkalosis in a maintenance dialysis patient who developed severe hypotension while undergoing a lactate hemofiltration procedure. A 73-year-old man with ESRD due to renovascular disease was used to ingesting up to 30 grams per day of a non-prescription medication (Effervescent granulate 250 grams, CRASTAN(TM), Pisa Italy) consisting of sodium bicarbonate, citric acid, glucose and lemon flavor. For technical problem lactate hemofiltration was performed and thirty minutes after dialysis was started a severe symptomatic hypotension occurred (blood pressure 65/35 mmHg). Lactate hemofiltration was suspended and one-hour later standard bicarbonate dialysis was performed without any clinical problem. The different mechanisms in acidosis buffering occurring in lactate and bicarbonate hemofiltration were discussed
Liver disease in diabetes mellitus: potential therapeutic value of vitamin E-silibyn complex
No full textThe liver has a central role in glucose homeostasis. In turn, glucose-induced signals modulate the transcrip- tional regulation of genes involved in the glycolysis and lipogenesis pathways and could favour fatty acid storage in the liver. The prevalence of hepatobiliary diseases is increased in patients with diabetes mellitus. Type 1 diabetes is associated with a hepatic form of microvascular disease (diabetic hepatosclerosis), hemochromatosis and autoimmune hepatitis. Type 2 diabetes is associated with nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) whose prevalence increases with multiple components of metabolic syndrome. Hepatitis C virus infection has been reported to be associated with and predispose to diabetes mellitus. Silibinin or silybin is a flavonoid derived from Silybum marianum and known to have hepatoprotective, anti-carcinogenic and anti-inflammatory effects. Silymarin is a standardised extract of four polyphenolic flavanolignans (silybin, isosilybin, silydianin and silychristin) from the seeds of Silybum marianum; it possesses a potent scavenging capacity of oxidizing free radicals whose mechanistic aspects have been extensively evaluated. This single herbal drug formulation is used for hepatoprotection although recent evidence in carbon tetrachlo- ride-induced cirrhotic rats suggests that chronic silymarin treatment might compromise the hemodynamic endothelial nitric oxide synthase activity. In order to enhance silymarin bioavailability flavonoid molecules have been converted into lipid-compatible molecular complexes, phytosomes. A new silybin-phosphatidylcholine-Vitamin E complex, character- ised by elevated oral bioavailability and lipophilicity, was effective on rat hepatic fibrosis induced by dimethylnitrosamine administration and by bile duct ligation. The complex has been suggested as a complementary approach to the treatment of patients with chronic liver damage. The manuscript provides a review of literature on this topic and discusses the potential usefulness of the complex to prevent/treats liver disease in diabetes as well as contraindications
Exploring Leukocyte Mitochondrial Membrane Potential in Type 1 Diabetes Families.
No full textProper cellular function requires the maintenance of mitochondrial membrane potential (MMP) sustained by the electron transport chain. Mitochondrial dysfunction is believed to play a role in the development of diabetes and diabetic complications possibly because of the active generation of free radicals. Since MMP can be investigated in clinical settings using fluorescent probes and living whole blood cells, mitochondrial membrane alterations have been observed in some chronic disorders. We have used the mitochondrial indicator 5,5',6,6'-tetra chloro-1,1',3,3'-tetraethylbenzimidazolyl-carbocyanine iodide (JC-1) in conjunction with flow cytometry to measure the MMP in peripheral blood granulocytes from type 1 diabetes (T1D) families. The intracellular ROS levels and the respiratory burst activity were also measured. Leukocyte MMP was elevated in 20 T1D patients and their 20 non-diabetic siblings compared with 25 healthy subjects without family history of T1D. Fasting plasma glucose was the only correlate of MMP. If confirmed by further observations, the functional implications of mitochondrial hyperpolarisation (probably different among different cells) will require extensive investigation
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