431 research outputs found
Supplemental material for Aspirin for primary prevention of stroke in individuals without cardiovascular disease—A meta-analysis
No full textSupplemental Material for Aspirin for primary prevention of stroke in individuals without cardiovascular disease—A meta-analysis by Conor Judge, Sarah Ruttledge, Robert Murphy, Elaine Loughlin, Sarah Gorey, Maria Costello, Aoife Nolan, John Ferguson, Martin O Halloran, Michelle O'Canavan and Martin J O'Donnell in International Journal of Stroke</p
Phthinomita jonesi Nolan & Cribb 2006, n. sp.
No full textPhthinomita jonesi n. sp. (Figs. 35–37) Type host: Siganus lineatus (Valenciennes), Goldlined Rabbitfish (Perciformes: Siganidae). Other hosts: S. argenteus (Quoy & Gaimard), Forktail Rabbitfish; S. doliatus (Cuvier), Barred Rabbitfish; S. vulpinus (Schlegel & Müller), Foxface. (Perciformes: Siganidae). Site in host: Intertrabecular spaces of ventricle (heart). Type locality: Lizard Island, northern Great Barrier Reef (14°40'S 145°27'E), Queensland. Material examined: ex S. lineatus, Lizard Island (QLD), Aug. 2002, May. 2004, thirtyfour specimens (Holotype no. QM G 225580; Paratype nos. QM G 225581–225589); ex S. argenteus, Lizard Island (QLD), Jan. 2003, (six specimens sequenced for ITS2); ex S. doliatus, Lizard Island (QLD), Jul. 2002, Aug. 2002, twentyfive partial and complete specimens (Paratype nos. QM G 225590–225602); ex S. vulpinus, Lizard Island (QLD), Aug. 2002, Jan. 2003, five specimens (Paratype nos. QM G 225603–225606). Collector: M.J. Nolan. Etymology Specific name for our friend Mr Conor Jones for his help on a collecting trip to Heron Island. Description Based on 64 partial and complete whole mounts. With features of genus. Body not curving dorsally posteriorly, slightly notched at male pore. Intestine; posterior caeca irregular in outline, distal extremities expanded. Anterior testis originates posterior to intercaecal field, in posterior third of body, margins lobed. Posterior testis ovoid, margins lobed. Cirrussac spherical to tearshaped. Internal seminal vesicle spherical, occupying ventral region of cirrussac; ejaculatory duct sinuous; prostatic cells small. Ovary ovoid, posterior to posterior margin of anterior testis. Oviduct originating at posterior margin of ovary, passing posterodorsally, straight. Vitelline duct forming between anterior margin of cirrussac and posterior margin of ovary, sinuous, dextral to cirrussac and posterior margin of ovary; vitelline reservoir forming lateral to cirrussac, convoluted, entering oötype posterodorsally. Oötype spherical, medial. Mehlis' gland extending anteriorly to posterior margin of cirrussac, extending posteriorly to anterior margin of posterior testis. Uterus extending from oötype sinuously, ventral to oviduct. Uterine chamber forming posterior to posterior margin of ovary, straight, thin, narrowing posteriorly before female genital pore. Vitelline follicles extending anteriorly past intestinal bifurcation, extending posteriorly past anterior margin of uterine chamber, filling intercaecal field, passing posteriorly dorsodextrally to anterior testis, anterior to anterior margin of ovary passes ventrally. Remarks The present material clearly belongs in the genus Phthinomita as it possesses characters differentially diagnostic of the genus. Phthinomita jonesi is distinguished by the combination of a body without a dorsal curve and only a slight notch level with the male pore, a body that is 45.8 times longer than wide on average, a spherical cirrussac, a uterine chamber that is 138 x 13 on average and vitelline follicles that extend anteriorly past the intestinal bifurcation. There are in addition, 1–34 base differences (0.3–10.3% sequence divergence) between the ITS2 rDNA sequence of P. jonesi and the remaining Phthinomita species sequenced here. There is a single base different between the sequences from P. jonesi (25 replicates), from four sympatric host species off Lizard Island and P. littlewoodi (eight replicates) from S. lineatus (Heron Island) and S. corallinus (Lizard Island).Published as part of Nolan, Matthew J. & Cribb, Thomas H., 2006, An exceptionally rich complex of Sanguinicolidae von Graff, 1907 (Platyhelminthes: Trematoda) from Siganidae, Labridae and Mullidae (Teleostei: Perciformes) from the Indo-west Pacific Region, pp. 1-80 in Zootaxa 1218 (1) on pages 48-50, DOI: 10.11646/zootaxa.1218.1.1, http://zenodo.org/record/506485
Multivariate elliptically contoured stable distributions: theory and estimation
No full textPublished in:
Nolan, J.P. Comput Stat (2013) 28: 2067. doi:10.1007/s00180-013-0396-7Stable distributions with elliptical contours are a class of distributions that are useful for modeling heavy tailed multivariate data. This paper describes the theory of such distributions, presents formulas for calculating their densities, and methods for fitting the data and assessing the fit. Efficient numerical routines are implemented and evaluated in simulations. Applications to data sets of a financial portfolio with 30 assets and to a bivariate radar clutter data set are presented
Current, emerging and future technologies for sensing the environment
No full textThis paper reviews current technologies that are used for environmental monitoring, and presents emerging technologies that will dramatically improve our ability to obtain spatially distributed, real-time data about key indicators of environmental quality at specific locations. Futuristic approaches to environmental monitoring that employ fundamental breakthroughs in materials science to revolutionise the way we monitor our environment will also be considered. In particular, approaches employing biomimetic and 'adaptive'/'stimuli-responsive' materials will be highlighted, as these could play an important role in the realization of small, low power, low cost, autonomous sensing and communications platforms that could form the building blocks of the much vaunted environmental 'sensor web'
First estimates of age, growth, and maturity of boarfish (Capros aper): a species newly exploited in the Northeast Atlantic
No full textThis is a pre-copy-editing, author-produced PDF of an article accepted for publication in ICES Journal of Marine Science following peer review. The definitive publisher-authenticated version “White, E., Minto, C., Nolan, C. P., King, E., Mullins, E., and Clarke, M. 2011. First estimates of age, growth, and maturity of boarfish (Capros aper): a species newly exploited in the Northeast Atlantic. – ICES Journal of Marine Science, 68: 61–66” is available online at: http://icesjms.oxfordjournals.org/content/68/1/61peer-reviewedBoarfish in the Northeast Atlantic have recently been exploited commercially for fishmeal. It is a sexually dimorphic species with an estimated maximum age of 26 years, late age at maturity (A50 = 5.25 years), relatively fast rate of growth (K = 0.186 year−1), and a small asymptotic length (L∞ = 128.9 mm)
Safety and security review for the process industries : application of HAZOP, PHA, what-if and SVA reviews /
No full textDrawing on decades of industry experience, well-known safety author and senior Loss Prevention specialist at Saudi Aramco Dennis Nolan has distilled the essential procedures and checklists into this practical guide. As well as guiding the reader through the selection and efficient and complete execution of the alphabet soup of Hazard Analysis and Safety Reviews (HAZOP, PHA, What-IF, SVA, LOPA, Bowtie ...), Nolan shares his personal experience and illustrates otherwise dry procedures with real-world examples. Written from the perspective of the author's extensive experience in loss prevention and safety engineering, this comprehensive manual is intended to provide guidance on all the qualitative hazard analyses conducted for industrial and commercial processes, specifically for Preliminary Hazard Analysis (PHA), What-If, and Hazard and Operability (HAZOP) review teams. It also demonstrates how the methodology and procedures used for these reviews can be adopted and applied to the Security Vulnerability Analysis (SVA) and Site Security Plan (SSP), requirements under the US Department of Homeland Security's Chemical Facility Anti-Terrorism Standard (CFATS) of 2007. The book's pragmatic approach describes the responsibilities, methods, and documentation required for the performance of such procedures and demonstrates how to conduct them in a timely, effective, objective, and consistent manner as may be prescribed by a company's Process Safety Management (PSM) policy and security requirements. As well as updates throughout to reflect changing practices, the third edition incorporates a new section on cost/benefit analysis and descriptions of new qualitative and quantitative safety reviews such as LOPA (Layer of Protection Analysis) and Bow-Tie (a graphical alternative to HAZOP) and a new chapter to address revalidation of studies/reports after 5 years. As well as providing invaluable personal insights from his career in the process industries, Dennis Nolan has also added a wealth of new real-world examples, bringing the form-filling to life. And for the first time, the forms and checklists are available for purchasers of the book to download - making this a complete safety review toolkit. Helps you to achieve compliance and avoid disasters: Dennis Nolan combines his extensive personal experience with relevant industry examples to provide the checklists and best-practice guidance needed to negotiate the labyrinth of Hazard Analysis and Safety Review procedures. Keeps your knowledge up-to-date: Coverage of the latest forms of Hazard Analysis and Safety Review, including LOPA and Bowtie Saves time ... and money: Demonstrates how each of the typically required reviews is related, so that information and conclusions used on one may be transferred or adapted for another. Also helps you avoid the fines associated with non-compliance, e.g. fines of up to 25k per day imposed by the Department of Homeland Security in the USA for non-compliance with the Chemical Facility Anti-Terrorism Standard (CFATS).Previous edition: 2008.Includes bibliographical references and index.Print version record.Elsevie
An analysis of the effects of various compounds on alcohol and high-fat-diet-induced steatosis in rats and mice:
No full textExcessive alcohol consumption is known to result in fatty liver, or steatosis. A high-fat, low-carbohydrate diet also results in fatty liver. Furthermore, fatty liver is known to precede cirrhosis in both animals and humans, and cirrhosis precedes primary hepatocellular carcinoma in humans. A series of studies was first undertaken to determine whether exercise and/or certain dietary manipulations could affect fatty liver. Long-Evans rats were given either a high-fat, low-carbohydrate or a high-carbohydrate, low-fat version of liquid diet with or without alcohol. Livers were analyzed for fat and measures of carbohydrate metabolism in liver and plasma were taken, as well as blood glucose alcohol concentrations. Next, added exercise (run wheel), caffeine, antioxidants such as Vitamin E, diphenyl-para-phenylene diamine (DPPD), and selenium were examined as were the dietary additives cranberry powder and soy protein. Finally, based on ambiguous results involving each agent separately, caffeine and DPPD were combined. Following the conclusion of rat studies, C57BL6 mice were given a modified version of the Leiber-deCarli liquid diet with alcohol. The calorie manipulation described above was repeated in mice to determine whether alcohol-induced fatty liver would be exacerbated in the presence of a high-fat diet. Subsequently, the dietary additives Vitamin E, DPPD and Trolox were added. Striatum was taken for HPLC, and livers were taken for liver fat analysis and malondialdehyde (MDA) assay (as a measure of oxidative stress) respectively. Finally, an experiment was undertaken to determine a time course for withdrawal seizures in mice.
In rats, differences in liver glycogen did not account for differences in liver fat. Exercise and caffeine both resulted in significant changes in weight gain, and while combined they appeared to reduce alcohol-induced fatty liver, the effect was not significant. Separately, no protective properties of either exercise or caffeine were observed. Vitamin E and selenium were found to exacerbate alcohol-induced fatty liver, while DPPD did not. Neither cranberry powder nor soy protein affected alcohol-induced fatty liver. DPPD combined with caffeine reduced alcohol-induced fatty liver significantly (p<0.05).
Adult mice were able to tolerate 4.5% ethanol in a high-fat liquid diet. The high-fat diet resulted in liver fat values significantly higher than high-carbohydrate when combined with alcohol. Vitamin E appeared to exacerbate fatty liver in mice, but differences were not significant. There were significant differences in oxidative stress; Vitamin E and Trolox reduced MDA significantly over diet plus alcohol alone. All animals experienced withdrawal seizures between 3 and 5 hours after removal of alcohol. There were significant differences in serotonin turnover (5HIAA/5HT) in animals fed a high-fat diet without alcohol vs. chow controls.Ph.D.Includes bibliographical references (p. 52-60)by Bonnie Nola
Size, shape and shell morphology in the Antarctic limpet Nacella concinna at Signy Island, South Orkney Islands
No full textComparison of the size, shape and shell morphology in littoral and sub-littoral morphs of the Antarctic limpet Nacella concinna reveal differences in shell morphology which are enhanced by structural anomalies within the shells of the two types. Infestation of sub-littoral shells by the conchocelis phase of an endolithic alga significantly affects shell density and total chlorophyll levels in the two shell morphs. The surface sculpture of sub-littoral shells is characterised by a series of grooves, the configuration of which closely resembles that of the radular teeth in N. concinna. Limpets utilise the available food supply within the shell matrix of other limpets by grazing the shell material. Epibiotic growth of calcareous algae prevent erosion and preserve underlying shell layers. In severe cases, where protection is lacking, intraspecific shell grazing may remove parts of the shell exposing the internal tissues.
The Dominican Gull, Larus dominicanus, is a major shore predator of both shell morphs. Gull middens contain both shell types but are dominated by the more accessible littoral shells. Comparison of living populations and midden assemblages indicates that size and shape selection of prey occurs, with pear-shaped limpets between 21 mm and 29 mm in length being taken preferentially.
Apparent differences in shell form are induced by physical, biological and behavioural influences. Littoral animals are robust in nature, resist avian pre-dation and are not extensively grazed whereas those of the sub-littoral are not subject to the same degree of predatory attention but suffer a gradual depletion of their shallower shell form through a combination of algal infection and intraspecific shell grazing
Life on the land : the interrelationship between identity and community in the Irish fiction of Maria Edgeworth, William Carleton and Charles Lever
No full textThis thesis examines and evaluates the response made by three
nineteenth century Irish writers of fiction to the most pressing
social problem of their time, namely: How might life on the land
be firmly established and maintained? The three writers concerned
— Maria Edgeworth, William Carleton and Charles Lever — are shown
to possess a common artistic vision, which is preserited as an answer
to the question posed. The answer consists of a demonstration of
how the resources of an enabling individual must blend with the
requirements of life on the land as it is.
By way of introduction, the significance of the theme for
both the literary and socio—political contexts of the period
(1800-1872) is described, and the problems of dealing with-nineteenth
century Irish fiction — problems concerned with its status
in the national cultural heritage, its variety and its artistic
characteristics — are outlined.
The four Irish novels of Maria Edgeworth are given a special
status in her overall output, and her handling of the theme in them
is considered as the prototype of her successors' manner of dealing
with it. Carleton and Lever are taken as portraying the Edgeworth
model under stress. Carleton's work is represented by a selection
of pieces from his Traits and Stories of the Irish Peasantry;
Lever's by three novels from the 1850's and '60's. All three
writers are located in their contemporary cultural milieux, and
their individual treatments of the theme are described and compared.
In conclusion, a general characterisation of the type of fiction
produced by the trio is offered, and a basis for its artistic
relationship to Irish fiction of more recent times is rehearsed.
The thesis facilitates a new periodisation of the history of
nineteenth century Irish fiction. It also offers a revised
conception of a tradition, of Irish fiction. These are the
contributions it makes to knowledge of the subject treated
Knowing the code
No full textPublished in:
Cytometry part A, Volume 85, Issue 1, January 2014, Pages 10–1
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