323,392 research outputs found
Exposure to the agricultural fungicide tebuconazole promotes Aspergillus fumigatus cross-resistance to clinical azoles. [Comini S. is the co-first author; Banche G. is the corresponding author; Cuffini A.M. is the co-corresponding author]
No full textResistance to clinical triazoles in Aspergillus fumigatus is a growing concern for individuals at high risk of Aspergillus infection. Two triazole resistance selection routes are currently being investigated: one occurring in triazole-treated patients in healthcare settings, and the second taking place in the environment due to the widespread use of agricultural triazoles. This study aimed to assess the ability of agricultural azoles to promote cross-resistance to clinical azoles in A. fumigatus. Five A. fumigatus isolates susceptible to clinical azoles were exposed to the triazole 14α-demethylase inhibitor, tebuconazole (TBC), and then antifungal susceptibility tests for voriconazole, itraconazole, posaconazole and isavuconazole were performed. Under TBC selection pressure, all A. fumigatus isolates exhibited resistance to clinical triazoles. However, only two displayed a multiresistant phenotype to clinical azoles. TBC exposure was also associated with delayed conidia formation and progressive absence of conidiation. Noteworthy, no TBC-exposed clones harbored TR34/L98H mutation, as judged by real-time PCR assays. The observation that TBC exposure promotes cross-resistance to clinical triazoles warrants careful and thorough assessment of the human health risk associated with agricultural azoles. The absence of TR34/L98H mutation in cross-resistant A. fumigatus isolates suggests that other cyp51A mutations may be involved in clinical azole cross-resistance
Comini, T J, 5713807
No full textThis record was harvested from a previous catalogue system and will be withdrawn in 2025. Information in this record may be superseded or incomplete. Visit this record in UMA's new catalogue at: https://archives.library.unimelb.edu.au/nodes/view/378271Surname: COMINI
Given Name(s) or Initials: T J
Military Service Number or Last Known Location: 5713807
Missing, Wounded and Prisoner of War Enquiry Card Index Number: SEA-1776192084
Item: [2016.0049.10565] "Comini, T J, 5713807
Evaluation of the Amplex eazyplex SuperBug Acineto test for direct detection of multidrug- resistant Acinetobacter baumannii bloodstream infections in high endemicity settings [S. Comini is the corresponding author]
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Investigation on the O-3 sensitivity properties of WO3 thin films prepared by sol-gel, thermal evaporation and r.f. sputtering techniques
No full textWO3 thin films have been deposited on alumina substrates provided with platinum interdigital electrodes by sol-gel (SG), r.f. sputtering (RFS), and vacuum thermal evaporation (VTE) techniques and annealed at temperatures between 500 degrees C and 600 degrees C for 1 to 30 h in static air. The morphology, crystalline phase and chemical composition of the films have been characterised using SEM, glancing XRD and XPS techniques. The electrical response has been measured exposing the films to O-3 (10-180 ppb), NO2 (0.2-1 ppm), NOx (27 ppm NO and 1 ppm NO,) at different operating temperatures ranging between 200 and 400 degrees C and humid air at 50% R.R. SG prepared films have shown bigger responses (S = I-Air/I-gas) with respect to VTE and RFS for all the investigated gases and operating temperatures. RFS prepared has resulted to be less sensitive, but faster in the response and more stable in terms of signal reproducibility. The response to O-3 has been found to be at maximum at 400 degrees C. At this temperature the response to 80 ppb of ozone has been: S = 35 (SG), S = 18 (VTE) and S = 5 (RFS). The NO2 and NOx response reached the maximum at 200 degrees C and becomes negligible at 400 degrees C. Improvements on the O-3 gas sensitivity and selectivity can be achieved by fixing the operating temperature of the films at 400 degrees C. (C) 2000 Elsevier Science S.A. All rights reserved. RI Faglia, Guido/E-6991-2010; Sberveglieri, Giorgio/A-5030-2010; li , yongxiang/C-5059-2009; Comini, Elisabetta/C-6721-200
Acta et decreta synodi dioecesanae pistoriensis an. MDCCLXXXVI : pars I : compectens acta et decreta
No full textSign.: []\p1\s, A-X\p8\s, Y\p10\sPor. con grav. xi
Preparation and Characterization of Tin Oxide Nanowires on SiC
No full textInterest in nanowires of metal oxide oxides has been exponentially growing in the last years, due to the attracting potential of application in electronic, optical and sensor field. We have focused our attention on the sensing properties of semiconducting nanowires as conductometric and optical gas sensors. Single crystal tin dioxide nanostructures were synthesized to explore and study their capability in form of multi-nanowires sensors. The nanowires of SnO2 have been used to produce a novel gas sensor based on Pt/oxide/SiC structure and operating as Schottky diode. For the first time, a reactive oxide layer in this device has been replaced by SnO2 nanowires. Proposed sensor has maintained the advantageous properties of known SiC- based MOS devices, that can be employed for the monitoring of gases (hydrogen and hydrocarbons) emitted by industrial combustion processes
On Polymorphic Recursion, Type Systems, and Abstract Interpretation
No full textThe problem of typing polymorphic recursion (i.e. recursive function definitions rec{x = e} where different occurrences of x in e are used with different types) has been investigated both by people working on type systems and by people working on abstract interpretation.
Recently, Gori and Levi have developed a family of abstract interpreters that are able to type all the ML typable recursive definitions and interesting examples of polymorphic recursion. The problem of finding type systems corresponding to their abstract interpreters was open (such systems would lie between the let-free fragments of the ML and of the Milner-Mycroft systems).
In this paper we exploit the notion of principal typing to: (i) provide a complete stratification of (let-free) Milner-Mycroft typability, and (ii) solve the problem of finding type systems corresponding to the type abstract interpreters proposed by Gori and Levi
TRSynth: a Tool for Automatic Inference of Term Equivalence in Left-linear Term Rewriting Systems
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